Piperacillin/Tazobactam - Revision history

Danbot: Remove disease-specific entries now covered by AntibioticDose (1 sections)

2026-03-20T11:07:45Z

Remove disease-specific entries now covered by AntibioticDose (1 sections)

← Older revision		Revision as of 11:07, 20 March 2026
Line 14:		Line 14:
	**Off-label: may reduce costs without sacrificing efficacy<ref>Shea KM, Cheatham SC, Smith DW, Wack MF, Sowinski KM, Kays MB. Comparative pharmacodynamics of intermittent and prolonged infusions of [[piperacillin/tazobactam]]using Monte Carlo simulations and steady-state pharmacokinetic data from hospitalized patients. Ann Pharmacother. 2009;43(11):1747-54.</ref><ref>Kaufman SE, Donnell RW, Hickey WS. Rationale and evidence for extended infusion of piperacillin-tazobactam. [http://www.ncbi.nlm.nih.gov/pubmed/21817083 Am J Health Syst Pharm. 2011 Aug 15;68(16):1521-6.]</ref>		**Off-label: may reduce costs without sacrificing efficacy<ref>Shea KM, Cheatham SC, Smith DW, Wack MF, Sowinski KM, Kays MB. Comparative pharmacodynamics of intermittent and prolonged infusions of [[piperacillin/tazobactam]]using Monte Carlo simulations and steady-state pharmacokinetic data from hospitalized patients. Ann Pharmacother. 2009;43(11):1747-54.</ref><ref>Kaufman SE, Donnell RW, Hickey WS. Rationale and evidence for extended infusion of piperacillin-tazobactam. [http://www.ncbi.nlm.nih.gov/pubmed/21817083 Am J Health Syst Pharm. 2011 Aug 15;68(16):1521-6.]</ref>

	~~===[[Diverticulitis]]===~~
	*{{Piperacillin/Tazobactam Diverticulitis}}

	==Pediatric Dosing<ref>Red Book, 2012</ref>==		==Pediatric Dosing<ref>Red Book, 2012</ref>==

Danbot: Remove disease-specific dosing covered by dynamic SMW tables

2026-03-20T02:57:22Z

Remove disease-specific dosing covered by dynamic SMW tables

@@ Line 16: / Line 16: @@
 ===[[Diverticulitis]]===
 *{{Piperacillin/Tazobactam Diverticulitis}}
 ==Pediatric Dosing<ref>Red Book, 2012</ref>==
@@ Line 35: / Line 27: @@
 **100mg piperacillin/kg/dose q8 hours
 *Max: 16 g/day
 ===Indications by Disease===

Danbot: Restore original dosing content alongside dynamic SMW tables

2026-03-20T02:37:14Z

Restore original dosing content alongside dynamic SMW tables

← Older revision		Revision as of 02:37, 20 March 2026
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	==Adult Dosing==		==Adult Dosing==
			===General===
			*3.375 g IV q6 hours
			*Alt: 4.5 g q6-8 hours
			*Max: 18 g/day

			===Extended Interval Dosing===
			*3.375 g IV infused over 4 hours q8 hours
			**Off-label: may reduce costs without sacrificing efficacy<ref>Shea KM, Cheatham SC, Smith DW, Wack MF, Sowinski KM, Kays MB. Comparative pharmacodynamics of intermittent and prolonged infusions of [[piperacillin/tazobactam]]using Monte Carlo simulations and steady-state pharmacokinetic data from hospitalized patients. Ann Pharmacother. 2009;43(11):1747-54.</ref><ref>Kaufman SE, Donnell RW, Hickey WS. Rationale and evidence for extended infusion of piperacillin-tazobactam. [http://www.ncbi.nlm.nih.gov/pubmed/21817083 Am J Health Syst Pharm. 2011 Aug 15;68(16):1521-6.]</ref>

			===[[Diverticulitis]]===
			*{{Piperacillin/Tazobactam Diverticulitis}}

			===[[Pneumonia]]===
			*CAP
			**3.375 g IV q6 hours x 7-10 days
			**Only for P. aeruginosa caused or from aspiration<ref>Mandell, 2007</ref>
			*Nosocomial
			**4.5 g IV q6 hours or 3.375 g IV q4 hours x 7-14 days
			**+ aminoglycoside or antipseudomonal fluoroquinolone

			==Pediatric Dosing<ref>Red Book, 2012</ref>==
			'''A Piperacillin/Taxobactam 3.375g vial contains 3g piperacillin and 0.375g tazobactam (8:1 ratio)'''
			===General===
			*'''<2 months'''
			**100mg piperacillin/kg/dose IV q6 hours
			*'''2-9 months'''
			**80mg piperacillin/kg/dose IV q8 hours
			*'''>9 months'''
			**100mg piperacillin/kg/dose q8 hours
			*Max: 16 g/day

			===[[Appendicitis]] and/or [[Peritonitis]]===
			*2-9 months
			**80mg piperacillin/kg/dose IV q8 hours
			*>9 months
			**≤40 kg: 100mg piperacillin/kg/dose IV q8 hours
			**>40 kg: 3.375g (3000mg piperacillin) IV q6 hours
			*Max: 16 g/day

			===Cystic Fibrosis, Pseudomonal Infection===
			*240-400mg piperacillin/kg/day IV divided q8 hours;
			**Consider higher dose: 450-600mg/kg/day IV divided q4-6 hours<ref>Zobell JT, Waters CD, Young DC, et al, "Optimization of Anti-Pseudomonal Antibiotics for Cystic Fibrosis Pulmonary Exacerbations: II. Cephalosporins and Penicillins," Pediatr Pulmonol, 2013, 48(2):107-22. PubMed 22949297</ref>


	===Indications by Disease===		===Indications by Disease===
	{{#ask: [[Has DrugName::Piperacillin/Tazobactam]] [[Has Population::Adult]]		{{#ask: [[Has DrugName::Piperacillin/Tazobactam]] [[Has Population::Adult]]
	\|?Treats disease=Disease		\|?Treats disease=Disease
	\|?Has Dose=Dose		\|?Has Dose=Dose
	\|?Has Context=Context		\|?Has Context=Context
	\|format=table		\|format=table
	\|limit=50		\|limit=50
	\|mainlabel=-		\|mainlabel=-
	\|headers=show		\|headers=show
	\|sort=Treats disease		\|sort=Treats disease
	}}		}}

	==Pediatric Dosing==		==Pediatric Dosing==

	===Indications by Disease===		===Indications by Disease===
	{{#ask: [[Has DrugName::Piperacillin/Tazobactam]] [[Has Population::Pediatric]]		{{#ask: [[Has DrugName::Piperacillin/Tazobactam]] [[Has Population::Pediatric]]
	\|?Treats disease=Disease		\|?Treats disease=Disease
	\|?Has Dose=Dose		\|?Has Dose=Dose
	\|?Has Context=Context		\|?Has Context=Context
	\|format=table		\|format=table
	\|limit=50		\|limit=50
	\|mainlabel=-		\|mainlabel=-
	\|headers=show		\|headers=show
	\|sort=Treats disease		\|sort=Treats disease
	}}		}}

Danbot: Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

2026-03-20T01:51:47Z

Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

← Older revision		Revision as of 01:51, 20 March 2026
Line 5:		Line 5:

	==Adult Dosing==		==Adult Dosing==
	===~~General~~===		===Indications by Disease===
	*3.375 g IV q6 hours		{{#ask: [[Has DrugName::Piperacillin/Tazobactam]] [[Has Population::Adult]]
	*Alt: 4.5 g q6-~~8 hours~~		\|?Treats disease=Disease
	*Max: 18 g/day		\|?Has Dose=Dose
			\|?Has Context=Context
			\|format=table
			\|limit=50
			\|mainlabel=-
			\|headers=show
			\|sort=Treats disease
			}}

	==~~=Extended Interval~~ Dosing===		==Pediatric Dosing==
	*3.375 g IV infused over 4 hours q8 hours		===Indications by Disease===
	**Off-label: may reduce costs without sacrificing efficacy<ref>Shea KM, Cheatham SC, Smith DW, Wack MF, Sowinski KM, Kays MB. Comparative pharmacodynamics of intermittent and prolonged infusions of [[piperacillin/tazobactam]]using Monte Carlo simulations and steady-state pharmacokinetic data from hospitalized patients. Ann Pharmacother. 2009;43(11):1747-54.</ref><ref>Kaufman SE, Donnell RW, Hickey WS. Rationale and evidence for extended infusion of piperacillin-tazobactam. [http://www.ncbi.nlm.nih.gov/pubmed/21817083 Am J Health Syst Pharm. 2011 Aug 15;68(16):1521-6.]</ref>		{{#ask: [[Has DrugName::Piperacillin/Tazobactam]] [[Has Population::Pediatric]]
			\|?Treats disease=Disease
	===~~[[Diverticulitis]]~~===		\|?Has Dose=Dose
	*{{Piperacillin/Tazobactam ~~Diverticulitis}}~~		\|?Has Context=Context
			\|format=table
	~~===~~[[~~Pneumonia~~]]===		\|limit=50
	*CAP		\|mainlabel=-
	**3.375 g IV q6 hours x 7-10 days		\|headers=show
	**Only for P. aeruginosa caused or from aspiration<ref>Mandell, 2007</ref>		\|sort=Treats disease
	*Nosocomial		}}
	**4.5 g IV q6 hours or 3.375 g IV q4 hours x 7-14 days
	**+ aminoglycoside or antipseudomonal fluoroquinolone

	==~~Pediatric Dosing<ref>Red Book, 2012</ref>==~~
	~~'''A Piperacillin/Taxobactam 3.375g vial contains 3g piperacillin and 0.375g tazobactam (8:1 ratio)'''~~
	=~~==General===~~
	*'''<2 months'''
	**100mg piperacillin/kg/dose IV q6 hours
	*'''2-~~9 months'''~~
	**80mg piperacillin/kg/dose IV q8 hours
	*'''>9 months'''
	**100mg piperacillin/kg/dose q8 hours
	*Max: 16 g/day

	~~===[[Appendicitis]] and/or [[Peritonitis]]==~~=
	*2-9 months
	**80mg piperacillin/kg/dose IV q8 hours
	*>9 months
	**≤40 kg: 100mg piperacillin/kg/dose IV q8 hours
	**>40 kg: 3.375g (3000mg piperacillin) IV q6 hours
	*Max: 16 g/day

	~~===Cystic Fibrosis, Pseudomonal Infection==~~=
	*240-400mg piperacillin/kg/day IV divided q8 hours;
	**Consider higher dose: 450-600mg/kg/day IV divided q4-6 hours<ref>Zobell JT, Waters CD, Young DC, et al, "Optimization of Anti-Pseudomonal Antibiotics for Cystic Fibrosis Pulmonary Exacerbations: II. Cephalosporins and Penicillins," Pediatr Pulmonol, 2013, 48(2):107-22. PubMed 22949297</ref>

	==Special Populations==		==Special Populations==

Ostermayer at 18:13, 18 July 2025

2025-07-18T18:13:45Z

← Older revision		Revision as of 18:13, 18 July 2025
Line 187:		Line 187:
	\| \|\|[[Acinetobacter sp.]]\|\|I		\| \|\|[[Acinetobacter sp.]]\|\|I
	\|-		\|-
	\| \|\|[[Pseudomonas aeruginosa]]\|\|'''S'''		\| \|\|[[Pseudomonas aeruginosa]]\|\|'''[[Has Antipseudomonal::S]]'''
	\|-		\|-
	\| \|\|[[Burkholderia cepacia]]\|\|X1		\| \|\|[[Burkholderia cepacia]]\|\|X1

Ostermayer at 17:49, 18 July 2025

2025-07-18T17:49:09Z

← Older revision		Revision as of 17:49, 18 July 2025
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	==General==		==General==
	*Type: [[Is ~~DrugClass~~::Anti-Pseudomonal]] [[Is DrugClass::Penicillin]]		*Type: [[Is PenicillinType::Anti-Pseudomonal]] [[Is DrugClass::Penicillin]]
	*Dosage Forms: 2.25gm vial, 3.375gm vial, 4.5gm vial, 40.5gm bulk bottle (Powder for reconstitution)		*Dosage Forms: 2.25gm vial, 3.375gm vial, 4.5gm vial, 40.5gm bulk bottle (Powder for reconstitution)
	*Common Trade Names: Zosyn		*Common Trade Names: Zosyn

Ostermayer at 17:46, 18 July 2025

2025-07-18T17:46:58Z

← Older revision		Revision as of 17:46, 18 July 2025
Line 1:		Line 1:
	==General==		==General==
	*Type: Anti-Pseudomonal [[Is DrugClass::Penicillin]]		*Type: [[Is DrugClass::Anti-Pseudomonal]] [[Is DrugClass::Penicillin]]
	*Dosage Forms: 2.25gm vial, 3.375gm vial, 4.5gm vial, 40.5gm bulk bottle (Powder for reconstitution)		*Dosage Forms: 2.25gm vial, 3.375gm vial, 4.5gm vial, 40.5gm bulk bottle (Powder for reconstitution)
	*Common Trade Names: Zosyn		*Common Trade Names: Zosyn

Ostermayer at 17:20, 18 July 2025

2025-07-18T17:20:08Z

← Older revision		Revision as of 17:20, 18 July 2025
Line 1:		Line 1:
	==General==		==General==
	*Type: Anti-Pseudomonal [[Penicillin]]		*Type: Anti-Pseudomonal [[Is DrugClass::Penicillin]]
	*Dosage Forms: 2.25gm vial, 3.375gm vial, 4.5gm vial, 40.5gm bulk bottle (Powder for reconstitution)		*Dosage Forms: 2.25gm vial, 3.375gm vial, 4.5gm vial, 40.5gm bulk bottle (Powder for reconstitution)
	*Common Trade Names: Zosyn		*Common Trade Names: Zosyn

Elcatracho: /* Serious */

2022-01-10T18:29:05Z

Serious

← Older revision		Revision as of 18:29, 10 January 2022
Line 75:		Line 75:
	===Serious===		===Serious===
	*[[Anaphylaxis]]		*[[Anaphylaxis]]
	*[[Serum ~~sicknes~~]]-like reaction		*[[Serum sickness]]-like reaction
	*[[DRESS syndrome]]		*[[DRESS syndrome]]
	*Acute generalized exanthematous pustulosis		*Acute generalized exanthematous pustulosis

Elcatracho: /* Serious */

2022-01-10T18:28:39Z

Serious

← Older revision		Revision as of 18:28, 10 January 2022
Line 75:		Line 75:
	===Serious===		===Serious===
	*[[Anaphylaxis]]		*[[Anaphylaxis]]
	*Serum ~~sickness~~-like reaction		*[[Serum sicknes]]-like reaction
	*[[DRESS syndrome]]		*[[DRESS syndrome]]
	*Acute generalized exanthematous pustulosis		*Acute generalized exanthematous pustulosis
Line 81:		Line 81:
	*Interstitial nephritis		*Interstitial nephritis
	*Superinfection		*Superinfection
	*C. difficile associated [[diarrhea]]		*[[C. difficile]] associated [[diarrhea]]
	*[[Hemolytic anemia]], [[leukopenia]], [[neutropenia]], [[pancytopenia]], agranulocytosis, [[thrombocytopenia]]		*[[Hemolytic anemia]], [[leukopenia]], [[neutropenia]], [[pancytopenia]], agranulocytosis, [[thrombocytopenia]]
	*Bleeding		*Bleeding