Portal vein thrombosis - Revision history

Danbot: Add verified PubMed references (PMIDs 38996577, 30771355)

2026-03-22T10:55:43Z

Add verified PubMed references (PMIDs 38996577, 30771355)

← Older revision		Revision as of 10:55, 22 March 2026
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	===Inciting Causes===		===Inciting Causes===
	*Abdominal [[sepsis]]		*Abdominal [[sepsis]] <ref>Elkrief L, et al. Portal vein thrombosis: diagnosis, management, and endpoints for future clinical studies. Lancet Gastroenterol Hepatol. 2024 Sep;9(9):859-883. PMID 38996577</ref>
	*Abdominal surgery		*Abdominal surgery
	*Behçet's syndrome		*Behçet's syndrome<ref>Intagliata NM, Caldwell SH, Tripodi A. Diagnosis, Development, and Treatment of Portal Vein Thrombosis in Patients With and Without Cirrhosis. Gastroenterology. 2019 May;156(6):1582-1599.e1. PMID 30771355</ref>
	*Cholangiocarcinoma		*Cholangiocarcinoma
	*[[Cirrhosis]]		*[[Cirrhosis]]

Rossdonaldson1: /* Background */

2024-11-13T23:19:11Z

Background

← Older revision		Revision as of 23:19, 13 November 2024
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	==Background==		==Background==
			[[File:Trombosisporta.png\|thumb\|Drawing of portal vein thrombosis.]]
	Portal vein thrombosis (PVT) is a vascular disease of the liver that occurs when a blood clot occurs in the hepatic portal vein, leading to increased pressure in the portal vein system and reduced blood supply to the liver.		Portal vein thrombosis (PVT) is a vascular disease of the liver that occurs when a blood clot occurs in the hepatic portal vein, leading to increased pressure in the portal vein system and reduced blood supply to the liver.

Rossdonaldson1: /* Evaluation */

2024-11-13T23:16:49Z

Evaluation

← Older revision		Revision as of 23:16, 13 November 2024
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	==Evaluation==		==Evaluation==
			[[File:R vs L Liver by CT.png\|thumb\|Phase contrast CT image. Contrast is perfusing the right liver but not the left due to a left portal vein thrombus.]]
	*Typically diagnosed on abdominal CT with contrast		*Typically diagnosed on abdominal CT with contrast
	*Filling defect on Doppler ultrasound		*Filling defect on Doppler ultrasound

ClaireLewis: /* Inciting Causes */

2020-10-25T17:43:49Z

Inciting Causes

← Older revision		Revision as of 17:43, 25 October 2020
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	*Cholangiocarcinoma		*Cholangiocarcinoma
	*[[Cirrhosis]]		*[[Cirrhosis]]
	*[[Collagen vascular ~~diseases~~]] (eg, lupus)		*[[Collagen vascular disease]]s (eg, lupus)
	*Compression or invasion of the portal vein by tumor (eg, pancreatic cancer)		*Compression or invasion of the portal vein by tumor (eg, pancreatic cancer)
	*[[Diverticulitis]]		*[[Diverticulitis]]

ClaireLewis at 17:43, 25 October 2020

2020-10-25T17:43:29Z

← Older revision		Revision as of 17:43, 25 October 2020
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	===Inciting Causes===		===Inciting Causes===
	*Abdominal sepsis		*Abdominal [[sepsis]]
	*Abdominal surgery		*Abdominal surgery
	*Behçet's syndrome		*Behçet's syndrome
	*Cholangiocarcinoma		*Cholangiocarcinoma
	*[[Cirrhosis]]		*[[Cirrhosis]]
	*Collagen vascular diseases (eg, lupus)		*[[Collagen vascular diseases]] (eg, lupus)
	*Compression or invasion of the portal vein by tumor (eg, pancreatic cancer)		*Compression or invasion of the portal vein by tumor (eg, pancreatic cancer)
	*[[Diverticulitis]]		*[[Diverticulitis]]
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	*[[Hepatocellular carcinoma]]		*[[Hepatocellular carcinoma]]
	*[[Inflammatory bowel disease]]		*[[Inflammatory bowel disease]]
	*Inherited thrombophilias (e.g. factor V Leiden deficiency, protein C or S deficiency, antiphospholipid ~~antibody~~ syndrome)		*Inherited thrombophilias (e.g. factor V Leiden deficiency, protein C or S deficiency, [[antiphospholipid syndrome]])
	*Myeloproliferative ~~syndromes~~ (e.g. [[polycythemia vera]] or essential ~~thrombocythemia~~)		*[[Myeloproliferative disorders]] (e.g. [[polycythemia vera]] or [[essential thrombocytosis]])
	*[[Omphalitis]]		*[[Omphalitis]]
	*Oral contraceptives		*Oral contraceptives
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	==Clinical Features==		==Clinical Features==
	===Acute===		===Acute===
	*Upper abdominal pain developing suddenly or progressing over a few days		*Upper [[abdominal pain]] developing suddenly or progressing over a few days
	*Possibly accompanied by nausea, hepatomegaly, splenomegaly; may be accompanied by persistent non-spiking fever in the setting of systemic inflammation		*Possibly accompanied by [[nausea]], [[hepatomegaly]], splenomegaly; may be accompanied by persistent non-spiking [[fever]] in the setting of systemic inflammation
	*Other signs/symptoms based on underlying cause (e.g. bleeding disorders, hepatic stigmata if due to cirrhosis)		*Other signs/symptoms based on underlying cause (e.g. bleeding disorders, hepatic stigmata if due to cirrhosis)
	*May be clinically silent in a portion of patients and diagnosed incidentally during a CT exam for other reasons (e.g. acute [[pancreatitis]])		*May be clinically silent in a portion of patients and diagnosed incidentally during a CT exam for other reasons (e.g. acute [[pancreatitis]])
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	==Management==		==Management==
	=== Acute ===		=== Acute ===
	*In non-cirrhotic, LMWH -> warfarin x 6 months		*In non-cirrhotic, [[LMWH]] -> [[warfarin]] x 6 months
	=== Chronic ===		=== Chronic ===
	*In non-cirrhotic or hypercoagulable, anticoagulation after screening for varices		*In non-cirrhotic or hypercoagulable, anticoagulation after screening for varices
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	5. Friedman LS (2020). "Noncirrhotic Portal Hypertension". In Papadakis MA, McPhee SJ, Rabow MW (eds.). ''Current Medical Diagnosis and Treatment 2020''. McGraw-Hill.		5. Friedman LS (2020). "Noncirrhotic Portal Hypertension". In Papadakis MA, McPhee SJ, Rabow MW (eds.). ''Current Medical Diagnosis and Treatment 2020''. McGraw-Hill.
			[[Category:Vascular]]

Rossdonaldson1: /* Differential Diagnosis */

2020-05-21T15:04:12Z

Differential Diagnosis

← Older revision		Revision as of 15:04, 21 May 2020
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	*[[Budd-Chiari syndrome]]		*[[Budd-Chiari syndrome]]
	*[[Portal vein thrombosis]]		*[[Portal vein thrombosis]]
			*[[Venous thromboembolism]]

	==Evaluation==		==Evaluation==

Rossdonaldson1: /* See Also */

2020-05-21T15:03:57Z

Rossdonaldson1: /* Background */

2020-05-21T15:02:15Z

Background

← Older revision		Revision as of 15:02, 21 May 2020
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	==Background==		==Background==
	~~[[File:Gray1121.png\|thumb\|Posterior abdominal wall, after removal of the peritoneum, showing kidneys, suprarenal capsules, and great vessels. (Hepatic veins labeled at center top.)]]~~
	Portal vein thrombosis (PVT) is a vascular disease of the liver that occurs when a blood clot occurs in the hepatic portal vein, leading to increased pressure in the portal vein system and reduced blood supply to the liver.		Portal vein thrombosis (PVT) is a vascular disease of the liver that occurs when a blood clot occurs in the hepatic portal vein, leading to increased pressure in the portal vein system and reduced blood supply to the liver.

Rossdonaldson1: /* Background */

2020-05-21T15:01:22Z

Background

← Older revision		Revision as of 15:01, 21 May 2020
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	==Background==		==Background==
			[[File:Gray1121.png\|thumb\|Posterior abdominal wall, after removal of the peritoneum, showing kidneys, suprarenal capsules, and great vessels. (Hepatic veins labeled at center top.)]]
	Portal vein thrombosis (PVT) is a vascular disease of the liver that occurs when a blood clot occurs in the hepatic portal vein, leading to increased pressure in the portal vein system and reduced blood supply to the liver.		Portal vein thrombosis (PVT) is a vascular disease of the liver that occurs when a blood clot occurs in the hepatic portal vein, leading to increased pressure in the portal vein system and reduced blood supply to the liver.

Rossdonaldson1: /* Differential Diagnosis */

2020-05-21T15:01:08Z

Differential Diagnosis

← Older revision		Revision as of 15:01, 21 May 2020
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	==Differential Diagnosis==		==Differential Diagnosis==
	*Mesenteric vein thrombosis		*Mesenteric vein thrombosis
			*[[Budd-Chiari syndrome]]
			*[[Portal vein thrombosis]]

	==Evaluation==		==Evaluation==

← Older revision		Revision as of 15:03, 21 May 2020
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	*[[Budd-Chiari syndrome]] (hepatic vein thrombosis)		*[[Budd-Chiari syndrome]] (hepatic vein thrombosis)
	*Pylephlebitis		*Pylephlebitis
			*[[Venous thromboembolism]]

	==External Links==		==External Links==