Propofol - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:57:20Z

Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T17:23:53Z

Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

2026-03-20T16:42:02Z

Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

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 *Has significant anti-emetic activity
 *Associated with static or reduced intracranial pressure in head injured patients requiring [[ICU Sedation]]<ref>McKeage, K. and Perry, C. M. (2003) ‘Propofol’, CNS Drugs, 17(4), pp. 235–272. </ref>
 ==See Also==

2023-12-05T14:20:24Z

Pharmacology

← Older revision		Revision as of 14:20, 5 December 2023
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	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 40 minutes (initial); 24-72 hr (after 10-day infusion)
	*Metabolism: Hepatic		*Metabolism: Hepatic
	*Excretion: Renal		*Excretion: Renal

2021-03-08T15:52:24Z

General

2021-02-21T03:17:08Z

ICU Sedation

← Older revision		Revision as of 03:17, 21 February 2021
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	*Avoid prolonged use, especially of high doses, to avoid propofol infusion syndrome (PRIS)		*Avoid prolonged use, especially of high doses, to avoid propofol infusion syndrome (PRIS)
	*[[PRIS]] usually associated with >65 mcg/kg/min for >24hrs, and critically ill patients with increased endogenous glucocorticoids and catecholamines		*[[PRIS]] usually associated with >65 mcg/kg/min for >24hrs, and critically ill patients with increased endogenous glucocorticoids and catecholamines
	**[[PRIS]]: Heart failure, [[Rhabdomyolysis]], metabolic acidosis, renal failure		**[[PRIS]]: [[Heart failure]], [[Rhabdomyolysis]], [[metabolic acidosis]], renal failure
	*Propofol drip of these high dosages can be seen in post-intubation status epilepticus (drip 2-10mg/kg/hr)		*Propofol drip of these high dosages can be seen in post-intubation [[status epilepticus]] (drip 2-10mg/kg/hr)

	==Pediatric Dosing==		==Pediatric Dosing==

2020-11-26T22:45:17Z

References

← Older revision		Revision as of 22:45, 26 November 2020
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	[[Category:Pharmacology]]		[[Category:Pharmacology]]
	[[Category:Critical Care]]		[[Category:Critical Care]]
	~~Propofol: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.~~

2020-11-26T22:45:01Z

2020-11-26T22:44:50Z

ICU Sedation

← Older revision		Revision as of 22:44, 26 November 2020
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	*5-50 mcg/kg/min IV, increase 5 mcg/kg/min q10min		*5-50 mcg/kg/min IV, increase 5 mcg/kg/min q10min
	*Avoid prolonged use, especially of high doses, to avoid propofol infusion syndrome (PRIS)		*Avoid prolonged use, especially of high doses, to avoid propofol infusion syndrome (PRIS)
	*PRIS usually associated with >65 mcg/kg/min for >24hrs, and critically ill patients with increased endogenous glucocorticoids and catecholamines		*[[PRIS]] usually associated with >65 mcg/kg/min for >24hrs, and critically ill patients with increased endogenous glucocorticoids and catecholamines
	**PRIS: Heart failure, [[Rhabdomyolysis]], metabolic acidosis, renal failure		**[[PRIS]]: Heart failure, [[Rhabdomyolysis]], metabolic acidosis, renal failure
	*Propofol drip of these high dosages can be seen in post-intubation status epilepticus (drip 2-10mg/kg/hr)		*Propofol drip of these high dosages can be seen in post-intubation status epilepticus (drip 2-10mg/kg/hr)

2020-11-21T23:10:28Z

Pediatric Dosing

← Older revision		Revision as of 23:10, 21 November 2020
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	*Induction (3-16 yo) at 2.5-3.5 mg/kg IV		*Induction (3-16 yo) at 2.5-3.5 mg/kg IV
	*[[Procedural sedation]] 1 mg/kg (max 40 mg), then 0.5 mg/kg PRN (max 20 mg)		*[[Procedural sedation]] 1 mg/kg (max 40 mg), then 0.5 mg/kg PRN (max 20 mg)
			*Pediatric population especially at risk for [[Propofol infusion syndrome\|propofol infusion syndrome (PRIS)]]

	==Special Populations==		==Special Populations==