Propofol infusion syndrome - Revision history

Elcatracho: /* Background */

2021-02-21T03:19:02Z

Background

← Older revision		Revision as of 03:19, 21 February 2021
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	==Background==		==Background==
	*PRIS = propofol infusion syndrome		*PRIS = [[propofol]] infusion syndrome
	*Refractory [[bradycardia]] and [[hypotension\|cardiovascular collapse]]		*Refractory [[bradycardia]] and [[hypotension\|cardiovascular collapse]]
	*Poorly understood mechanism		*Poorly understood mechanism

ClaireLewis at 20:39, 22 September 2019

2019-09-22T20:39:55Z

← Older revision		Revision as of 20:39, 22 September 2019
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	==Background==		==Background==
	*PRIS = propofol infusion syndrome		*PRIS = propofol infusion syndrome
	*Refractory bradycardia and cardiovascular collapse		*Refractory [[bradycardia]] and [[hypotension\|cardiovascular collapse]]
	*Poorly understood mechanism		*Poorly understood mechanism
	*Risk factors		*Risk factors
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	==Clinical Features==		==Clinical Features==
	*Elevated AG metabolic acidosis		*Elevated [[anion gap acidosis\|AG metabolic acidosis]]
	*Hypotension		*[[Hypotension]]
	*Bradycardia		*[[Bradycardia]]
	*[[Rhabdomyolysis]]		*[[Rhabdomyolysis]]
	*[[Hyperkalemia]]		*[[Hyperkalemia]]
	*AKI		*[[AKI]]
	*Hyperlipidemia		*Hyperlipidemia
	*Transaminitis, fatty liver		*Transaminitis, fatty liver
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	*[[ECG]]		*[[ECG]]
	**[[Brugada]] like pattern, coved-type		**[[Brugada]] like pattern, coved-type
	**RBBB		**[[RBBB]]
	**Heart block		**[[Heart block]]

	==Management==		==Management==
	*Immediate ~~discharge~~ of propofol infusion		*Immediate discontinuation of propofol infusion
	*Treatment of rhabdomyolysis, to include renal replacement therapy		*Treatment of [[rhabdomyolysis]], to include renal replacement therapy
	*Hemodynamic support, cardiac pacing		*Hemodynamic support, cardiac [[pacing]]
	*L-carnitine supplementation		*[[L-carnitine]] supplementation
	*Carbohydrate administration at 6-8mg/kg/min		*Carbohydrate administration at 6-8mg/kg/min
	*Hemodialysis		*[[Hemodialysis]]
	*ECMO in refractory cases		*[[ECMO]] in refractory cases

	==References==		==References==

Rossdonaldson1: Text replacement - "ECG" to "ECG"

2016-09-09T16:59:59Z

Text replacement - "*ECG" to "*ECG"

← Older revision		Revision as of 16:59, 9 September 2016
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	*Lactate, ABG		*Lactate, ABG
	*Propofol levels if available		*Propofol levels if available
	*ECG		*[[ECG]]
	**[[Brugada]] like pattern, coved-type		**[[Brugada]] like pattern, coved-type
	**RBBB		**RBBB

Neil.m.young: Text replacement - "==Diagnosis==" to "==Evaluation=="

2016-07-24T21:25:21Z

Text replacement - "==Diagnosis==" to "==Evaluation=="

← Older revision		Revision as of 21:25, 24 July 2016
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	*Transaminitis, fatty liver		*Transaminitis, fatty liver

	==~~Diagnosis~~==		==Evaluation==
	*Serum lipids (TGs, cholesterol)		*Serum lipids (TGs, cholesterol)
	*BMP, Cr		*BMP, Cr

Neil.m.young: Text replacement - "4 mg" to "4mg"

2016-07-21T04:54:15Z

Text replacement - "4 mg" to "4mg"

← Older revision		Revision as of 04:54, 21 July 2016
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	*Poorly understood mechanism		*Poorly understood mechanism
	*Risk factors		*Risk factors
	**High doses of (> ~~4 mg~~/kg/hr or 67 mcg/kg/min)		**High doses of (> 4mg/kg/hr or 67 mcg/kg/min)
	**Long duration (> 48 hrs)		**Long duration (> 48 hrs)
	**Younger age (PRIS first recognized in pediatric population)		**Younger age (PRIS first recognized in pediatric population)

Neil.m.young: Text replacement - "8 mg" to "8mg"

2016-07-20T21:54:32Z

Text replacement - "8 mg" to "8mg"

← Older revision		Revision as of 21:54, 20 July 2016
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	*Hemodynamic support, cardiac pacing		*Hemodynamic support, cardiac pacing
	*L-carnitine supplementation		*L-carnitine supplementation
	*Carbohydrate administration at 6-~~8 mg~~/kg/min		*Carbohydrate administration at 6-8mg/kg/min
	*Hemodialysis		*Hemodialysis
	*ECMO in refractory cases		*ECMO in refractory cases

Neil.m.young: /* Sources */

2016-06-26T14:32:26Z

Sources

← Older revision		Revision as of 14:32, 26 June 2016
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	*ECMO in refractory cases		*ECMO in refractory cases

	==~~Sources~~==		==References==
	*Fudickar A, Bein B. Propofol infusion syndrome: update of clinical manifestation and pathophysiology. Minerva Anestesiol. 2009 May;75(5):339-44		<references/>
	*Mirrakhimov AE et al. Propofol Infusion Syndrome in Adults: A Clinical Update. Critical Care Research and Practice. Volume 2015 (2015), Article ID 260385, 10 pages.

	[[Category:Critical Care]]		[[Category:Critical Care]]

Ostermayer: Text replacement - " d/c" to " discharge"

2016-06-21T16:49:22Z

Text replacement - " d/c" to " discharge"

← Older revision		Revision as of 16:49, 21 June 2016
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	==Management==		==Management==
	*Immediate ~~d/c~~ of propofol infusion		*Immediate discharge of propofol infusion
	*Treatment of rhabdomyolysis, to include renal replacement therapy		*Treatment of rhabdomyolysis, to include renal replacement therapy
	*Hemodynamic support, cardiac pacing		*Hemodynamic support, cardiac pacing

Neil.m.young at 14:59, 18 May 2016

2016-05-18T14:59:47Z

← Older revision		Revision as of 14:59, 18 May 2016
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	*Lactate, ABG		*Lactate, ABG
	*Propofol levels if available		*Propofol levels if available
	*~~EKG~~		*ECG
	**[[Brugada]] like pattern, coved-type		**[[Brugada]] like pattern, coved-type
	**RBBB		**RBBB

Kxl328 at 19:24, 29 April 2016

2016-04-29T19:24:45Z

← Older revision		Revision as of 19:24, 29 April 2016
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	*Fudickar A, Bein B. Propofol infusion syndrome: update of clinical manifestation and pathophysiology. Minerva Anestesiol. 2009 May;75(5):339-44		*Fudickar A, Bein B. Propofol infusion syndrome: update of clinical manifestation and pathophysiology. Minerva Anestesiol. 2009 May;75(5):339-44
	*Mirrakhimov AE et al. Propofol Infusion Syndrome in Adults: A Clinical Update. Critical Care Research and Practice. Volume 2015 (2015), Article ID 260385, 10 pages.		*Mirrakhimov AE et al. Propofol Infusion Syndrome in Adults: A Clinical Update. Critical Care Research and Practice. Volume 2015 (2015), Article ID 260385, 10 pages.

			[[Category:Critical Care]]