Protamine sulfate - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:56:35Z

Switch SMW query from broadtable to table format for better layout with TOC

← Older revision		Revision as of 21:56, 20 March 2026
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	\|?Has Route=Route		\|?Has Route=Route
	\|?Has Population=Population		\|?Has Population=Population
	\|format=~~broadtable~~		\|format=table
	\|headers=plain		\|headers=plain
	\|mainlabel=-		\|mainlabel=-

Danbot: Add SMW Indications by Condition query table

2026-03-20T18:54:39Z

Add SMW Indications by Condition query table

@@ Line 40: / Line 40: @@
 *Weak anticoagulant, heparin antagonist
 ==Comments==
 ==See Also==

Ostermayer: /* Adult Dosing */

2022-07-06T15:03:33Z

Adult Dosing

← Older revision		Revision as of 15:03, 6 July 2022
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	==Adult Dosing==		==Adult Dosing==
	*'''Major bleeding due to unfractionated heparin:'''		{{Heparin reversal}}
	**1 mg IV for every 100 units of heparin infused in past 3h
	**Do not infuse faster than 50mg/10min
	**If it has been >30min since last heparin injection, 0.5mg may be sufficient
	*Major bleeding due to low-molecular-weight heparin:
	**Protamine is less effective for bleeding from LMWH than it is with heparin-induced bleeds
	**'''Enoxaparin:''' 1 mg IV for every 1 mg enoxaparin administered in past 8h
	**'''Dalteparin:''' 1 mg IV for every 100 anti-Xa international units of dalteparin

	==Pediatric Dosing==		==Pediatric Dosing==

Ostermayer: /* Adult Dosing */

2022-07-06T15:02:27Z

Adult Dosing

← Older revision		Revision as of 15:02, 6 July 2022
Line 6:		Line 6:

	==Adult Dosing==		==Adult Dosing==
	*Major bleeding due to unfractionated heparin:		*'''Major bleeding due to unfractionated heparin:'''
	**1 mg IV for every 100 units of heparin infused in past 3h		**1 mg IV for every 100 units of heparin infused in past 3h
	**Do not infuse faster than 50mg/10min		**Do not infuse faster than 50mg/10min

Ostermayer: /* Adult Dosing */

2022-07-06T15:00:29Z

Adult Dosing

← Older revision		Revision as of 15:00, 6 July 2022
Line 9:		Line 9:
	**1 mg IV for every 100 units of heparin infused in past 3h		**1 mg IV for every 100 units of heparin infused in past 3h
	**Do not infuse faster than 50mg/10min		**Do not infuse faster than 50mg/10min
	**If it has been >30min since last heparin injection, ~~half dose~~ may be sufficient		**If it has been >30min since last heparin injection, 0.5mg may be sufficient
	*Major bleeding due to low-molecular-weight heparin:		*Major bleeding due to low-molecular-weight heparin:
	**Protamine is less effective for bleeding from LMWH than it is with heparin-induced bleeds		**Protamine is less effective for bleeding from LMWH than it is with heparin-induced bleeds
	**Enoxaparin: 1 mg IV for every 1 mg enoxaparin administered in past 8h		**'''Enoxaparin:''' 1 mg IV for every 1 mg enoxaparin administered in past 8h
	**Dalteparin: 1 mg IV for every 100 anti-Xa international units of dalteparin		**'''Dalteparin:''' 1 mg IV for every 100 anti-Xa international units of dalteparin

	==Pediatric Dosing==		==Pediatric Dosing==

Wgalvin85: /* References */ added

2019-04-02T19:39:01Z

References: added

← Older revision		Revision as of 19:39, 2 April 2019
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	==References==		==References==
	<references/>		<references/>
			* Protamine sulfate: Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019.
	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Wgalvin85: /* Pharmacology */ added

2019-04-02T19:38:27Z

Pharmacology: added

← Older revision		Revision as of 19:38, 2 April 2019
Line 40:		Line 40:
	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life:
			** ~7 minutes
	*Metabolism:		*Metabolism:
	*Excretion:		*Excretion:

	==Mechanism of Action==		==Mechanism of Action==

Alvarez13 at 00:25, 27 November 2016

2016-11-27T00:25:23Z

← Older revision		Revision as of 00:25, 27 November 2016
Line 29:		Line 29:
	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
	*Anaphylaxis (0.2% of patients), anaphylactoid reaction		*[[Anaphylaxis]](0.2% of patients), anaphylactoid reaction
	*Circulatory collapse, capillary leak, bradyarrhythmia, hypotension		*Circulatory collapse, capillary leak, bradyarrhythmia, hypotension
	*Pulmonary edema		*Pulmonary edema

	===Common===		===Common===
	*Flushing		*Flushing

ClaireLewis: Created page with "==Administration== Type: Antidote Dosage Forms: Routes of Administration: IV Common Trade Names: ==Adult Dosing== *Major bleeding due to unfractionated heparin: **1..."

2016-10-19T16:20:43Z

Created page with "==Administration== *Type: Antidote *Dosage Forms: *Routes of Administration: IV *Common Trade Names: ==Adult Dosing== *Major bleeding due to unfractionated heparin: **1..."

New page

==Administration==
*Type: [[Antidote]]
*Dosage Forms:
*Routes of Administration: IV
*Common Trade Names:

==Adult Dosing==
*Major bleeding due to unfractionated heparin:
**1 mg IV for every 100 units of heparin infused in past 3h
**Do not infuse faster than 50mg/10min
**If it has been >30min since last heparin injection, half dose may be sufficient
*Major bleeding due to low-molecular-weight heparin:
**Protamine is less effective for bleeding from LMWH than it is with heparin-induced bleeds
**Enoxaparin: 1 mg IV for every 1 mg enoxaparin administered in past 8h
**Dalteparin: 1 mg IV for every 100 anti-Xa international units of dalteparin

==Pediatric Dosing==
''Safety/Efficacy not well established in pediatrics, but unofficial suggested dosing similar to adult dosing''

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Renal dosing: no adjustment
*Hepatic dosing: no adjustment

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Anaphylaxis (0.2% of patients), anaphylactoid reaction
*Circulatory collapse, capillary leak, bradyarrhythmia, hypotension
*Pulmonary edema
===Common===
*Flushing
*Dyspnea
*Nausea/vomiting

==Pharmacology==
*Half-life:
*Metabolism:
*Excretion:

==Mechanism of Action==
*Weak anticoagulant, heparin antagonist
==Comments==

==See Also==
*[[Anticoagulant reversal]], [[Unfractionated heparin reversal]]
*[[Unfractionated heparin]], [[Low molecular weight heparin]]
==References==
<references/>
[[Category:Pharmacology]]

Protamine sulfate - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

Danbot: Add SMW Indications by Condition query table

Ostermayer: /* Adult Dosing */

Ostermayer: /* Adult Dosing */

Ostermayer: /* Adult Dosing */

Wgalvin85: /* References */ added

Wgalvin85: /* Pharmacology */ added

Alvarez13 at 00:25, 27 November 2016

ClaireLewis: Created page with "==Administration== *Type: Antidote *Dosage Forms: *Routes of Administration: IV *Common Trade Names: ==Adult Dosing== *Major bleeding due to unfractionated heparin: **1..."

ClaireLewis: Created page with "==Administration== Type: Antidote Dosage Forms: Routes of Administration: IV Common Trade Names: ==Adult Dosing== *Major bleeding due to unfractionated heparin: **1..."