Pyrantel Pamoate - Revision history

Danbot: Fix corrupted content: restore correct Pyrantel Pamoate (antiparasitic) content, was incorrectly showing Alprostadil

2026-03-20T12:12:19Z

Fix corrupted content: restore correct Pyrantel Pamoate (antiparasitic) content, was incorrectly showing Alprostadil

← Older revision		Revision as of 12:12, 20 March 2026
Line 1:		Line 1:
	==~~General~~==		==Administration==
	*~~AKA~~: ~~aloprostadil~~		*Type: [[Antiparasitic]]
	*~~Type~~: ~~smooth muscle relaxer, vasodilator~~		*Dosage Forms:
	*~~Dosage Forms~~: ~~intravenous, penile injection, penile suppository~~		*Routes of Administration: Oral
	*Common Trade Names: ~~[https://alprostadil.org Alprostadil], Prostin VR, Caverject, Muse, Edex~~		*Common Trade Names:
	*Uses: maintenance of [[patent ductus arteriosus]] in neonates with duct-dependent congenital heart defects; treatment of erectile dysfunction in adults

	==Adult Dosing==		==Adult Dosing==
			*11mg/kg once
	==Pediatric Dosing<ref> Donofrio MT, Moon-Grady AJ, Hornberger LK, Copel JA, Sklansky MS, Abuhamad A, Cuneo BF, Huhta JC, Jonas RA, Krishnan A, Lacey S, Lee W, Michelfelder EC Sr, Rempel GR, Silverman NH, Spray TL, Strasburger JF, Tworetzky W, Rychik J. Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American Heart Association. American Heart Association Adults With Congenital Heart Disease Joint Committee of the Council on Cardiovascular Disease in the Young and Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Council on Cardiovascular and Stroke Nursing.Circulation. 2014 May 27;129(21):2183-242. doi: 10.1161/01.cir.0000437597.44550.5d. Epub 2014 Apr 24.</ref>==
	*Start infusion at 0.05 mcg/kg/min IV
	**~~Titrate to 0.1 mcg~~/kg~~/min as tolerated, monitoring for hypotension (and apnea)~~


	===Indications by Disease===		===Indications by Disease===
Line 26:		Line 21:

	==Pediatric Dosing==		==Pediatric Dosing==
			*> 2yo: 11mg/kg once

	===Indications by Disease===		===Indications by Disease===
Line 41:		Line 37:
	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C
	*Lactation: ~~infant~~ risk cannot be ruled out		*[[Lactation risk categories\|Lactation risk]]: Infant risk cannot be ruled out
	*Renal ~~Dosing~~		*Renal dosing:
	**Adult		*Hepatic dosing:
	**Pediatric
	*Hepatic ~~Dosing~~
	**Adult
	**Pediatric

	==Contraindications==		==Contraindications==
Line 53:		Line 45:

	==Adverse Reactions==		==Adverse Reactions==
	*Beware of three common side effects that may require further resuscitation<ref>Martin RJ et al. Pathophysiologic Mechanisms Underlying Apnea of Prematurity. NeoReviews Vol.3 No.4 April 2002.</ref><ref>Segar JL. Protocol for Use of Prostaglandin E. University of Iowa Stead Family Children's Hospital. Accessed Dec 2016. https://uichildrens.org/health-library/protocol-use-prostaglandin-e?id=~~234424</ref>:~~		===Serious===
	**Apnea (12%), which requires respiratory monitoring with ETCO2 capnography, potential mechanical ventilation, ~~and/or ALS/PALS transport if needing transfer to higher level of care~~
	**Peripheral flushing with or without hypotension (10%), ~~which requires fluid resuscitation~~		===Common===
	**[[Fever]] (14%)		*Nausea/vomiting, diarrhea
	*Others:		*Headache, dizziness, somnolence
	**[[Hypotension]]
	**[[Bradycardia]]
	**[[Seizures]]

	==Pharmacology==		==Pharmacology==
	*Half-life: ~~5-10m~~		*Half-life:
	*Metabolism: ~~Lung~~		*Metabolism:
	*Excretion: ~~Renal~~		*Excretion: Fecal
	*Mechanism of Action~~: synthetic of endogenous prostaglandin~~
			==Mechanism of Action==
			*depolarizing neuromuscular blocking agent, causes spastic paralysis in the worms

	==Comments==		==Comments==
	*~~Cyanotic neonates~~ with ~~ductal-dependent lesions typically respond within 10-15 minutes~~, ~~but may not show response until several hours after the start of infusion.~~		*Indicated to treat infection with [[enterobius]], [[ascaris]], and other similar worms

	==See Also==		==See Also==
	*[[~~Tetralogy of fallot~~]]		*[[Parasitic diseases]]

	==References==		==References==
	<references/>		<references/>

	[[Category:Pharmacology]]		[[Category:Pharmacology]]
	[[Category:~~Pediatrics]]~~		[[Category:ID]]
	~~[[Category:Cardiology~~]]

Danbot: Restore original dosing content alongside dynamic SMW tables

2026-03-20T02:39:29Z

Restore original dosing content alongside dynamic SMW tables

← Older revision		Revision as of 02:39, 20 March 2026
Line 1:		Line 1:
	==~~Administration~~==		==General==
	*Type: ~~[[Antiparasitic]]~~		*AKA: aloprostadil
	*Dosage Forms:		*Type: smooth muscle relaxer, vasodilator
	*~~Routes of Administration~~: ~~Oral~~		*Dosage Forms: intravenous, penile injection, penile suppository
	*~~Common Trade Names~~:		*Common Trade Names: [https://alprostadil.org Alprostadil], Prostin VR, Caverject, Muse, Edex
			*Uses: maintenance of [[patent ductus arteriosus]] in neonates with duct-dependent congenital heart defects; treatment of erectile dysfunction in adults

	==Adult Dosing==		==Adult Dosing==

			==Pediatric Dosing<ref> Donofrio MT, Moon-Grady AJ, Hornberger LK, Copel JA, Sklansky MS, Abuhamad A, Cuneo BF, Huhta JC, Jonas RA, Krishnan A, Lacey S, Lee W, Michelfelder EC Sr, Rempel GR, Silverman NH, Spray TL, Strasburger JF, Tworetzky W, Rychik J. Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American Heart Association. American Heart Association Adults With Congenital Heart Disease Joint Committee of the Council on Cardiovascular Disease in the Young and Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and Council on Cardiovascular and Stroke Nursing.Circulation. 2014 May 27;129(21):2183-242. doi: 10.1161/01.cir.0000437597.44550.5d. Epub 2014 Apr 24.</ref>==
			*Start infusion at 0.05 mcg/kg/min IV
			**Titrate to 0.1 mcg/kg/min as tolerated, monitoring for hypotension (and apnea)


	===Indications by Disease===		===Indications by Disease===
	{{#ask: [[Has DrugName::Pyrantel Pamoate]] [[Has Population::Adult]]		{{#ask: [[Has DrugName::Pyrantel Pamoate]] [[Has Population::Adult]]
	\|?Treats disease=Disease		\|?Treats disease=Disease
	\|?Has Dose=Dose		\|?Has Dose=Dose
	\|?Has Context=Context		\|?Has Context=Context
	\|format=table		\|format=table
	\|limit=50		\|limit=50
	\|mainlabel=-		\|mainlabel=-
	\|headers=show		\|headers=show
	\|sort=Treats disease		\|sort=Treats disease
	}}		}}

	==Pediatric Dosing==		==Pediatric Dosing==

	===Indications by Disease===		===Indications by Disease===
	{{#ask: [[Has DrugName::Pyrantel Pamoate]] [[Has Population::Pediatric]]		{{#ask: [[Has DrugName::Pyrantel Pamoate]] [[Has Population::Pediatric]]
	\|?Treats disease=Disease		\|?Treats disease=Disease
	\|?Has Dose=Dose		\|?Has Dose=Dose
	\|?Has Context=Context		\|?Has Context=Context
	\|format=table		\|format=table
	\|limit=50		\|limit=50
	\|mainlabel=-		\|mainlabel=-
	\|headers=show		\|headers=show
	\|sort=Treats disease		\|sort=Treats disease
	}}		}}

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C
	*[[Lactation ~~risk categories\|Lactation risk]]~~: ~~Infant~~ risk cannot be ruled out		*Lactation: infant risk cannot be ruled out
	*Renal ~~dosing:~~		*Renal Dosing
	*Hepatic ~~dosing:~~		**Adult
			**Pediatric
			*Hepatic Dosing
			**Adult
			**Pediatric

	==Contraindications==		==Contraindications==
Line 41:		Line 53:

	==Adverse Reactions==		==Adverse Reactions==
	=~~==Serious===~~		*Beware of three common side effects that may require further resuscitation<ref>Martin RJ et al. Pathophysiologic Mechanisms Underlying Apnea of Prematurity. NeoReviews Vol.3 No.4 April 2002.</ref><ref>Segar JL. Protocol for Use of Prostaglandin E. University of Iowa Stead Family Children's Hospital. Accessed Dec 2016. https://uichildrens.org/health-library/protocol-use-prostaglandin-e?id=234424</ref>:
			**Apnea (12%), which requires respiratory monitoring with ETCO2 capnography, potential mechanical ventilation, and/or ALS/PALS transport if needing transfer to higher level of care
	~~===Common===~~		**Peripheral flushing with or without hypotension (10%), which requires fluid resuscitation
	*~~Nausea/vomiting, diarrhea~~		**[[Fever]] (14%)
	*~~Headache, dizziness, somnolence~~		*Others:
			**[[Hypotension]]
			**[[Bradycardia]]
			**[[Seizures]]

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 5-10m
	*Metabolism:		*Metabolism: Lung
	*Excretion: ~~Fecal~~		*Excretion: Renal
			*Mechanism of Action: synthetic of endogenous prostaglandin
	==Mechanism of Action==
	*depolarizing neuromuscular blocking agent, causes spastic paralysis in the worms

	==Comments==		==Comments==
	*~~Indicated to treat infection~~ with ~~[[enterobius]]~~, ~~[[ascaris]], and other similar worms~~		*Cyanotic neonates with ductal-dependent lesions typically respond within 10-15 minutes, but may not show response until several hours after the start of infusion.

	==See Also==		==See Also==
	*[[~~Parasitic diseases~~]]		*[[Tetralogy of fallot]]

	==References==		==References==
	<references/>		<references/>

	[[Category:Pharmacology]]		[[Category:Pharmacology]]
	[[Category:ID]]		[[Category:Pediatrics]]
			[[Category:Cardiology]]

Danbot: Replace manual dosing with dynamic SMW tables

2026-03-20T01:54:27Z

Replace manual dosing with dynamic SMW tables

@@ Line 6: / Line 6: @@
 ==Adult Dosing==
-*11mg/kg once
+===Indications by Disease===
 ==Pediatric Dosing==
-*> 2yo: 11mg/kg once
+===Indications by Disease===
 ==Special Populations==

ClaireLewis: /* References */

2019-09-23T22:10:18Z

References

← Older revision		Revision as of 22:10, 23 September 2019
Line 44:		Line 44:
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:ID]]

Mholtz: Text replacement - "* " to "*"

2017-07-10T23:05:38Z

Text replacement - "* " to "*"

← Older revision		Revision as of 23:05, 10 July 2017
Line 9:		Line 9:

	==Pediatric Dosing==		==Pediatric Dosing==
	* > 2yo: 11mg/kg once		*> 2yo: 11mg/kg once

	==Special Populations==		==Special Populations==

ClaireLewis: /* Administration */

2017-03-28T17:59:02Z

Administration

← Older revision		Revision as of 17:59, 28 March 2017
Line 1:		Line 1:
	==Administration==		==Administration==
	*Type: Antiparasitic		*Type: [[Antiparasitic]]
	*Dosage Forms:		*Dosage Forms:
	*Routes of Administration: Oral		*Routes of Administration: Oral
	*Common Trade Names:		*Common Trade Names:

	==Adult Dosing==		==Adult Dosing==

ClaireLewis at 20:58, 7 November 2016

2016-11-07T20:58:08Z

← Older revision		Revision as of 20:58, 7 November 2016
Line 36:		Line 36:

	==Comments==		==Comments==
	*Indicated to treat infection with [[enterobius]], [[~~ascarias~~]], and other similar worms		*Indicated to treat infection with [[enterobius]], [[ascaris]], and other similar worms

	==See Also==		==See Also==
	*[[Parasitic ~~infections~~]]		*[[Parasitic diseases]]

	==References==		==References==
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]

ClaireLewis: Created page with "==Administration== Type: Antiparasitic Dosage Forms: Routes of Administration: Oral Common Trade Names: ==Adult Dosing== 11mg/kg once ==Pediatric Dosing== > 2yo: 11..."

2016-11-07T20:57:21Z

Created page with "==Administration== *Type: Antiparasitic *Dosage Forms: *Routes of Administration: Oral *Common Trade Names: ==Adult Dosing== *11mg/kg once ==Pediatric Dosing== * > 2yo: 11..."

New page

==Administration==
*Type: Antiparasitic
*Dosage Forms:
*Routes of Administration: Oral
*Common Trade Names:

==Adult Dosing==
*11mg/kg once

==Pediatric Dosing==
* > 2yo: 11mg/kg once

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Renal dosing:
*Hepatic dosing:

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===

===Common===
*Nausea/vomiting, diarrhea
*Headache, dizziness, somnolence

==Pharmacology==
*Half-life:
*Metabolism:
*Excretion: Fecal

==Mechanism of Action==
*depolarizing neuromuscular blocking agent, causes spastic paralysis in the worms

==Comments==
*Indicated to treat infection with [[enterobius]], [[ascarias]], and other similar worms

==See Also==
*[[Parasitic infections]]

==References==
<references/>
[[Category:Pharmacology]]