Radiation proctocolitis - Revision history

Ostermayer: Prepared the page for translation

2026-01-04T23:55:44Z

Prepared the page for translation

← Older revision		Revision as of 23:55, 4 January 2026
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			<languages/>
			<translate>

	==Background==		==Background==

	* Injury to the colon following radiation therapy most commonly affecting the sigmoid colon and rectum.		* Injury to the colon following radiation therapy most commonly affecting the sigmoid colon and rectum.
	* Acute ( up to three months), Chronic ( 3 months to years later)		* Acute ( up to three months), Chronic ( 3 months to years later)
	*Results in majority from radiation to the lower abdomen and pelvis as in the cases of cancers of the rectum, colon, gonads, uterus, bladder, and prostate.		*Results in majority from radiation to the lower abdomen and pelvis as in the cases of cancers of the rectum, colon, gonads, uterus, bladder, and prostate.


	==Clinical Features==		==Clinical Features==


	===Uncomplicated===		===Uncomplicated===
	*[[Diarrhea]]
			*[[Special:MyLanguage/Diarrhea\|Diarrhea]]
	*Urgency		*Urgency
	*Mucus discharge		*Mucus discharge
	*Tenesmus		*Tenesmus
	*[[GI bleeding]] is more common in chronic radiation proctitis than acute radiation proctitis		*[[Special:MyLanguage/GI bleeding\|GI bleeding]] is more common in chronic radiation proctitis than acute radiation proctitis


	===Complicated===		===Complicated===

	*Radiation injury extending to genitourinary system		*Radiation injury extending to genitourinary system
	**urethral stenosis		**urethral stenosis
	**[[Cystitis]]		**[[Special:MyLanguage/Cystitis\|Cystitis]]
	**Ureteral scarring		**Ureteral scarring
	*Radiation injury extending to small bowel		*Radiation injury extending to small bowel
	**[[Small bowel obstruction]]		**[[Special:MyLanguage/Small bowel obstruction\|Small bowel obstruction]]
	**Small intestine bacterial overgrowth		**Small intestine bacterial overgrowth
	**Fistulae		**Fistulae


	==Differential Diagnosis==		==Differential Diagnosis==
	*[[Inflammatory bowel disease]]
	*[[Infectious colitis]]		*[[Special:MyLanguage/Inflammatory bowel disease\|Inflammatory bowel disease]]
			*[[Special:MyLanguage/Infectious colitis\|Infectious colitis]]
	*Diversion colitis		*Diversion colitis
	*[[Ischemic colitis]]		*[[Special:MyLanguage/Ischemic colitis\|Ischemic colitis]]
	*[[Diverticulitis]]		*[[Special:MyLanguage/Diverticulitis\|Diverticulitis]]
	*Chronic [[graft-versus-host disease]]		*Chronic [[Special:MyLanguage/graft-versus-host disease\|graft-versus-host disease]]


	==Evaluation==		==Evaluation==

	*Labs		*Labs
	**Stool C.diff toxin along with routine stool cultures		**Stool C.diff toxin along with routine stool cultures
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	**CT if obstructive symptoms are present		**CT if obstructive symptoms are present
	**MRI if suspicion is high for radiation-induced fistulae		**MRI if suspicion is high for radiation-induced fistulae


	==Management==		==Management==


	===Acute===		===Acute===

	*Generally self-limited		*Generally self-limited
	*approximately 20% of patients will need to lengthen time intervals between radiation therapy to recover		*approximately 20% of patients will need to lengthen time intervals between radiation therapy to recover
	*Hydration, [[steroids]], +/- 5-aminosalicylate enema, bowel regimen.		*Hydration, [[Special:MyLanguage/steroids\|steroids]], +/- 5-aminosalicylate enema, bowel regimen.


	===Chronic===		===Chronic===

	*Non-invasive		*Non-invasive
	**Anti-inflammatories		**Anti-inflammatories
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	**Endoscopic treatment with ablation therapy : Topical formalin, Laser, Argon plasma coagulation		**Endoscopic treatment with ablation therapy : Topical formalin, Laser, Argon plasma coagulation
	**Surgical resection last resort		**Surgical resection last resort


	==Disposition==		==Disposition==

	*Treat outpatient		*Treat outpatient
	*Severe cases that are candidates for surgery should be admitted		*Severe cases that are candidates for surgery should be admitted


	==See Also==		==See Also==
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	==References==		==References==

	<references/>		<references/>

	[[Category:Heme/Onc]]		[[Category:Heme/Onc]]
	[[Category:GI]]		[[Category:GI]]
			</translate>

ClaireLewis: /* Differential Diagnosis */

2019-08-17T17:50:15Z

Differential Diagnosis

← Older revision		Revision as of 17:50, 17 August 2019
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	*Diversion colitis		*Diversion colitis
	*[[Ischemic colitis]]		*[[Ischemic colitis]]
	*[[Diverticulitis		*[[Diverticulitis]]
	*Chronic [[graft-versus-host disease]]		*Chronic [[graft-versus-host disease]]

ClaireLewis at 02:10, 27 January 2019

2019-01-27T02:10:03Z

← Older revision		Revision as of 02:10, 27 January 2019
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	==Clinical Features==		==Clinical Features==
	===Uncomplicated===		===Uncomplicated===
	*Diarrhea		*[[Diarrhea]]
	*Urgency		*Urgency
	*Mucus discharge		*Mucus discharge
	*Tenesmus		*Tenesmus
	*~~Bleeding~~ is more common in chronic radiation proctitis than acute radiation proctitis		*[[GI bleeding]] is more common in chronic radiation proctitis than acute radiation proctitis

	===Complicated===		===Complicated===
	*Radiation injury extending to genitourinary system		*Radiation injury extending to genitourinary system
	**urethral stenosis		**urethral stenosis
	**Cystitis		**[[Cystitis]]
	**Ureteral scarring		**Ureteral scarring
	*Radiation injury extending to small bowel		*Radiation injury extending to small bowel
	**Small bowel obstruction		**[[Small bowel obstruction]]
	**Small intestine bacterial overgrowth		**Small intestine bacterial overgrowth
	**Fistulae		**Fistulae

	==Differential Diagnosis==		==Differential Diagnosis==
	*~~Ulcerative colitis~~		*[[Inflammatory bowel disease]]
	*Crohns disease		*[[Infectious colitis]]
	*~~Inflammatory Bowel Disease~~
	*CMV Colitis
	*Infectious~~/parasitic enterocolitis~~
	*Diversion colitis		*Diversion colitis
	*Ischemic colitis		*[[Ischemic colitis]]
	*~~Diverticular colitis~~		*[[Diverticulitis
	*~~Chronis~~ graft-versus-host ~~diease~~		*Chronic [[graft-versus-host disease]]

	==Evaluation==		==Evaluation==
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	*Generally self-limited		*Generally self-limited
	*approximately 20% of patients will need to lengthen time intervals between radiation therapy to recover		*approximately 20% of patients will need to lengthen time intervals between radiation therapy to recover
	*Hydration, steroids, +/- 5-aminosalicylate enema, bowel regimen.		*Hydration, [[steroids]], +/- 5-aminosalicylate enema, bowel regimen.

	===Chronic===		===Chronic===

Iwm5010: /* Acute */

2017-11-24T12:42:12Z

Acute

← Older revision		Revision as of 12:42, 24 November 2017
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	*Generally self-limited		*Generally self-limited
	*approximately 20% of patients will need to lengthen time intervals between radiation therapy to recover		*approximately 20% of patients will need to lengthen time intervals between radiation therapy to recover
	*Hydration, steroids, +/- 5-aminosalicylate enema.		*Hydration, steroids, +/- 5-aminosalicylate enema, bowel regimen.

	===Chronic===		===Chronic===

Rossdonaldson1 at 12:17, 23 November 2017

2017-11-23T12:17:04Z

← Older revision		Revision as of 12:17, 23 November 2017
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	**Hyperbaric O2		**Hyperbaric O2
	**Antioxidants: Vitamin A, E, C.		**Antioxidants: Vitamin A, E, C.
	*Invasive		*Invasive<ref>Vanneste BGL, Van De Voorde L, de Ridder RJ, Van Limbergen EJ, Lambin P, van Lin EN. Chronic radiation proctitis: tricks to prevent and treat. International Journal of Colorectal Disease. 2015;30:1293-1303. doi:10.1007/s00384-015-2289-4.</ref>
	**Endoscopic treatment with ablation therapy : Topical formalin, Laser, Argon plasma coagulation		**Endoscopic treatment with ablation therapy : Topical formalin, Laser, Argon plasma coagulation
	**Surgical resection last resort		**Surgical resection last resort
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	==References==		==References==
	<references/>		<references/>

	Vanneste BGL, Van De Voorde L, de Ridder RJ, Van Limbergen EJ, Lambin P, van Lin EN. Chronic radiation proctitis: tricks to prevent and treat. International Journal of Colorectal Disease. 2015;30:1293-1303. doi:10.1007/s00384-015-2289-4.

	[[Category:Heme/Onc]]		[[Category:Heme/Onc]]
	[[Category:GI]]		[[Category:GI]]

Iwm5010: /* Management */

2017-11-22T18:34:02Z

Management

← Older revision		Revision as of 18:34, 22 November 2017
Line 1:		Line 1:
	==Background==		==Background==
	* Injury to the colon following radiation therapy most commonly affecting the sigmoid colon and rectum.		* Injury to the colon following radiation therapy most commonly affecting the sigmoid colon and rectum.
			* Acute ( up to three months), Chronic ( 3 months to years later)
	*Results in majority from radiation to the lower abdomen and pelvis as in the cases of cancers of the rectum, colon, gonads, uterus, bladder, and prostate.		*Results in majority from radiation to the lower abdomen and pelvis as in the cases of cancers of the rectum, colon, gonads, uterus, bladder, and prostate.
	*Occurs up to 6 weeks after receiving radiation therapy

	==Clinical Features==		==Clinical Features==
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	*Endoscopy and biopsy		*Endoscopy and biopsy
	**Nonspecific findings		**Nonspecific findings
	**Pallor, friability		**Pallor, friability, ulcerations, bleeding
	**Telangiectatic		**Telangiectatic with bleeding
	**Avoid ~~this procedure in severe proctitis~~ as ~~it may~~ facilitate fistula formation		**Avoid biopsy unless malignancy is suspected as facilitate fistula/non healing wound formation

	*Imaging		*Imaging
	**CT if obstructive symptoms are present		**CT if obstructive symptoms are present
	**MRI if suspicion is high for radiation-induced fistulae		**MRI if suspicion is high for radiation-induced fistulae

	==Management==		==Management==
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	===Chronic===		===Chronic===
	*Non-invasive		*Non-invasive
	**~~anti~~-inflammatories		**Anti-inflammatories
	**~~sucralfate~~		**Sucralfate enema
	**short-chain fatty acids		**short-chain fatty acids
	**Hyperbaric O2		**Hyperbaric O2
	**Antioxidants		**Antioxidants: Vitamin A, E, C.
	*Invasive		*Invasive
	**ablation ~~surgery~~		**Endoscopic treatment with ablation therapy : Topical formalin, Laser, Argon plasma coagulation
	**~~Resection if localized~~		**Surgical resection last resort

	==Disposition==		==Disposition==
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	==References==		==References==
	<references/>		<references/>

			Vanneste BGL, Van De Voorde L, de Ridder RJ, Van Limbergen EJ, Lambin P, van Lin EN. Chronic radiation proctitis: tricks to prevent and treat. International Journal of Colorectal Disease. 2015;30:1293-1303. doi:10.1007/s00384-015-2289-4.

	[[Category:Heme/Onc]]		[[Category:Heme/Onc]]
	[[Category:GI]]		[[Category:GI]]

Mholtz at 23:49, 30 October 2017

2017-10-30T23:49:10Z

← Older revision		Revision as of 23:49, 30 October 2017
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	==References==		==References==
	<references/>		<references/>
	~~# Do, Nhue L., et al. “Radiation Proctitis: Current Strategies in Management.” Gastroenterology Research and Practice, vol. 2011, 2011, pp. 1–9., doi~~:~~10.1155/2011~~/~~917941.~~
	~~# Gilinsky NH, Burns DG, Barbezat GO, et al. The natural history of radiation-induced proctosigmoiditis: an analysis of 88 patients. Q J Med 1983; 52:40.~~		[[Category:Heme/Onc]]
	~~# Tagkalidis PP, Tjandra JJ. Chronic radiation proctitis. ANZ J Surg 2001; 71:230.~~		[[Category:GI]]
	~~# Shepherd NA. Pathological mimics of chronic inflammatory bowel disease. J Clin Pathol 1991; 44~~:~~726.~~

Rossdonaldson1: /* Clinical Features */

2017-10-29T03:50:54Z

Clinical Features

← Older revision		Revision as of 03:50, 29 October 2017
Line 5:		Line 5:

	==Clinical Features==		==Clinical Features==
	*Uncomplicated		===Uncomplicated===
	**Diarrhea		*Diarrhea
	**Urgency		*Urgency
	**Mucus discharge		*Mucus discharge
	**Tenesmus		*Tenesmus
	**Bleeding is more common in chronic radiation proctitis than acute radiation proctitis		*Bleeding is more common in chronic radiation proctitis than acute radiation proctitis

	*Complicated		===Complicated===
	**Radiation injury extending to genitourinary system		*Radiation injury extending to genitourinary system
	***urethral stenosis		**urethral stenosis
	***Cystitis		**Cystitis
	***Ureteral scarring		**Ureteral scarring
			*Radiation injury extending to small bowel
	**Radiation injury extending to small bowel		**Small bowel obstruction
	***Small bowel obstruction		**Small intestine bacterial overgrowth
	***Small intestine bacterial overgrowth		**Fistulae
	***Fistulae

	==Differential Diagnosis==		==Differential Diagnosis==

Rossdonaldson1: /* Acute radiation proctitis */

2017-10-29T03:50:05Z

Acute radiation proctitis

← Older revision		Revision as of 03:50, 29 October 2017
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	==Management==		==Management==
	===Acute ~~radiation proctitis~~===		===Acute===
	*Generally self-limited		*Generally self-limited
	*approximately 20% of patients will need to lengthen time intervals between radiation therapy to recover		*approximately 20% of patients will need to lengthen time intervals between radiation therapy to recover

Rossdonaldson1: /* Management */

2017-10-29T03:49:53Z

Management

← Older revision		Revision as of 03:49, 29 October 2017
Line 52:		Line 52:

	==Management==		==Management==
	*Acute radiation proctitis		===Acute radiation proctitis===
	**Generally self-limited		*Generally self-limited
	**approximately 20% of patients will need to lengthen time intervals between radiation therapy to recover		*approximately 20% of patients will need to lengthen time intervals between radiation therapy to recover
	**Hydration, steroids, +/- 5-aminosalicylate enema.		*Hydration, steroids, +/- 5-aminosalicylate enema.

	*Chronic		===Chronic===
	**Non-invasive		*Non-invasive
	***anti-inflammatories		**anti-inflammatories
	***sucralfate		**sucralfate
	***short-chain fatty acids		**short-chain fatty acids
	***Hyperbaric O2		**Hyperbaric O2
	***Antioxidants		**Antioxidants
			*Invasive
	**Invasive		**ablation surgery
	***ablation surgery		**Resection if localized
	***Resection if localized

	==Disposition==		==Disposition==