Rifampin - Revision history

Danbot: Remove disease-specific entries now covered by AntibioticDose (14 sections)

2026-03-20T11:08:23Z

Remove disease-specific entries now covered by AntibioticDose (14 sections)

@@ Line 11: / Line 11: @@
 ==Adult Dosing==
@@ Line 50: / Line 27: @@
 ==Pediatric Dosing==
 ===Indications by Disease===

Danbot: Remove disease-specific dosing covered by dynamic SMW tables

2026-03-20T02:58:09Z

Remove disease-specific dosing covered by dynamic SMW tables

← Older revision		Revision as of 02:58, 20 March 2026
Line 17:		Line 17:
	===Inactive [[TB]], HIV+===		===Inactive [[TB]], HIV+===
	*600mg PO daily for 4 months		*600mg PO daily for 4 months
	~~===[[Meningitis]]===~~
	*600mg IV once daily (with [[vancomycin]]/[[cephalosporin]])
	===[[Neisseria meningitidis\|Meningococcal Prophylaxis]]===		===[[Neisseria meningitidis\|Meningococcal Prophylaxis]]===
	*600 mg PO BID for two days		*600 mg PO BID for two days
Line 27:		Line 25:
	*15-20mg/kg/day PO/IV in 1 or 2 divided doses for at least 6 weeks in combination with a [[tetracycline]]		*15-20mg/kg/day PO/IV in 1 or 2 divided doses for at least 6 weeks in combination with a [[tetracycline]]
	**MAX 600 to 900mg/day		**MAX 600 to 900mg/day
	~~===Infective endocarditis===~~
	*300mg IV or PO every 8 hours for a minimum of 6 weeks, in combination with appropriate antimicrobial therapy
	===Hansen Disease===		===Hansen Disease===
	*Paucibacillary, single lesion		*Paucibacillary, single lesion

Danbot: Restore original dosing content alongside dynamic SMW tables

2026-03-20T02:37:40Z

Restore original dosing content alongside dynamic SMW tables

@@ Line 11: / Line 11: @@
 ==Adult Dosing==
 ===Indications by Disease===
 {{#ask: [[Has DrugName::Rifampin]] [[Has Population::Adult]]
-|?Treats disease=Disease
+ |?Treats disease=Disease
-|?Has Dose=Dose
+ |?Has Dose=Dose
-|?Has Context=Context
+ |?Has Context=Context
-|format=table
+ |format=table
-|limit=50
+ |limit=50
-|mainlabel=-
+ |mainlabel=-
-|headers=show
+ |headers=show
-|sort=Treats disease
+ |sort=Treats disease
 }}
 ==Pediatric Dosing==
 ===Indications by Disease===
 {{#ask: [[Has DrugName::Rifampin]] [[Has Population::Pediatric]]
-|?Treats disease=Disease
+ |?Treats disease=Disease
-|?Has Dose=Dose
+ |?Has Dose=Dose
-|?Has Context=Context
+ |?Has Context=Context
-|format=table
+ |format=table
-|limit=50
+ |limit=50
-|mainlabel=-
+ |mainlabel=-
-|headers=show
+ |headers=show
-|sort=Treats disease
+ |sort=Treats disease
 }}

Danbot: Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

2026-03-20T01:52:43Z

Replace manual dosing with dynamic SMW tables (Adult + Pediatric)

← Older revision		Revision as of 01:52, 20 March 2026
Line 11:		Line 11:

	==Adult Dosing==		==Adult Dosing==
	===~~Active [[TB]]~~===		===Indications by Disease===
	*10mg/kg/day (in combination with [[~~isoniazid~~]] ~~and~~ [[~~pyrazinamide~~]]~~) PO or IV for 2 months~~		{{#ask: [[Has DrugName::Rifampin]] [[Has Population::Adult]]
	**Then 10mg/kg/day (in combination with [[isoniazid]]) for 4 months or longer as needed		\|?Treats disease=Disease
	**MAX, 600mg/day		\|?Has Dose=Dose
	===~~Inactive [[TB]], HIV+==~~=		\|?Has Context=Context
	*600mg PO daily for 4 months		\|format=table
	~~===[[Meningitis]]==~~=		\|limit=50
	*600mg IV once daily (with [[vancomycin]]/[[cephalosporin]])		\|mainlabel=-
	~~===[[Neisseria meningitidis~~\|~~Meningococcal Prophylaxis]]==~~=		\|headers=show
	*600 mg PO BID for two days		\|sort=Treats disease
			}}

	===~~Bartonellosis~~===		==Pediatric Dosing==
	*300mg PO or IV q12h plus [[doxycycline]]		===Indications by Disease===
	~~===Brucellosis===~~		{{#ask: [[Has DrugName::Rifampin]] [[Has Population::Pediatric]]
	*15-20mg/kg/day PO/IV in 1 or 2 divided doses for at least 6 weeks in combination with a [[tetracycline]]		\|?Treats disease=Disease
	**MAX 600 to 900mg/day		\|?Has Dose=Dose
	===~~Infective endocarditis===~~		\|?Has Context=Context
	*300mg IV or PO every 8 hours for a minimum of 6 weeks, in combination with appropriate antimicrobial therapy		\|format=table
	~~===Hansen~~ Disease===		\|limit=50
	*Paucibacillary, single lesion		\|mainlabel=-
	**600 mg PO x1 with [[~~ofloxacin~~]] ~~and~~ [[~~minocycline~~]]		\|headers=show
	*Paucibacillary		\|sort=Treats disease
	**600 mg PO qmo x 6mo with [[dapsone]]		}}
	*Multibacillary
	**600 mg PO qmo x 12mo with [[dapsone]] and [[clofazimine]]
	===~~[[Anthrax]], systemic~~===
	*600 mg IV q12h for at least 2 wk as part of a multi-drug regimen
	**Switch to PO abx x60 days total if inhalational exposure

	~~==Pediatric Dosing==~~
	~~===Active [[TB]]===~~
	*<15 yo
	**10-20 mg/kg PO/IV qd for at least 6mo
	***Max: 600 mg/day
	*15+ yo
	**10 mg/kg PO/IV qd for at least 6mo
	***Max: 600 mg/day
	~~===Latent [[TB]]===~~
	*<15 yo
	**10-20 mg/kg PO/IV qd x4mo
	***Max: 600 mg/day
	*15+ yo
	**10 mg/kg PO/IV qd x4mo
	***Max: 600 mg/day
	~~===[[H. influenza]] prophylaxis===~~
	*<1 mo
	**10mg/kg PO/IV q24h x4 days
	***Max: 600 mg/day
	*1+ mo
	**20 mg/kg PO/IV q24h x4 days
	**Max: 600 mg/day
	~~===Meningcococcal prophylaxis===~~
	*<1 mo
	**5mg/kg PO/IV q24h x4 days
	***Max: 600 mg/day
	*1+ mo
	**10 mg/kg PO/IV q24h x4 days
	**Max: 600 mg/day
	~~===[[Endocarditis]], Staphylococcal prosthetic valve===~~
	*20 mg/kg/day PO/IV divided q8h for at least 6wk with [[gentamicin]] and [[nafcillin]]
	**Max 900 mg/day
	~~===Hansen Disease===~~
	*Paucibacillary, 10-14 yo
	**450mg PO qmo x6mo with [[dapsone]]
	*Paucibacillary, 15+ yo
	**600 mg PO qmo x 6mo with [[dapsone]]
	*Multibacillary, 10-14 yo
	**450mg PO qmo x 12mo with [[dapsone]] and [[clofazimine]]
	*Multibacillary, 15+ yo
	**600 mg PO qmo x 12mo with [[dapsone]] and [[clofazimine]]
	~~===[[Anthrax]], systemic===~~
	*Neonates >32 wk gestation
	**10-20 mg/kg/day IV divided q12-24h for at least 2 wk as part of multi-drug regimen
	*1+ mo
	**20 mg/kg/day IV divided q12h for at least 2 wk as part of multi-drug regimen
	***Max: 300 mg/dose
	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C

Ostermayer: /* Serious */

2022-01-21T08:00:49Z

Serious

← Older revision		Revision as of 08:00, 21 January 2022
Line 123:		Line 123:
	*C. Diff associated diarrhea		*C. Diff associated diarrhea
	*Psychosis		*Psychosis
	*[[~~Anterior~~ Uveitis]]		*[[Uveitis]]

	===Common===		===Common===

Ostermayer: /* Serious */

2022-01-21T08:00:08Z

Serious

← Older revision		Revision as of 08:00, 21 January 2022
Line 123:		Line 123:
	*C. Diff associated diarrhea		*C. Diff associated diarrhea
	*Psychosis		*Psychosis
			*[[Anterior Uveitis]]

	===Common===		===Common===

Ostermayer: /* Adverse Reactions */

2022-01-21T07:59:27Z

Adverse Reactions

← Older revision		Revision as of 07:59, 21 January 2022
Line 139:		Line 139:
	*[[Dyspnea]]		*[[Dyspnea]]
	*Contact lens staining		*Contact lens staining

			==Acute Overdose==
			*Diarrhea is unique to rifampin toxicity in comparison to other antituberculous medications<ref>Broadwell R. et al. Suicide by rifampin overdose. JAMA. 1978; 240:2283.13.</ref>

	==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==		==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==

Ostermayer: /* General */

2022-01-21T07:55:30Z

General

← Older revision		Revision as of 07:55, 21 January 2022
Line 3:		Line 3:
	*Dosage Forms: 150, 300; PO, IV		*Dosage Forms: 150, 300; PO, IV
	*Common Trade Names: Rifadin		*Common Trade Names: Rifadin
			==Pharmacology==
			*Half-life: 1.5-5hours (increased if there is hepatic dysfunction)
			**Rifampin autoinduces its own metabolism so half-life is decreased with subsequent dosing.
			*Metabolism: Hepatic
			*Excretion: Bile; Urine <30%
			*Mechanism of Action: inhibits bacterial RNA synthesis

	==Adult Dosing==		==Adult Dosing==

Ostermayer: /* Pharmacology */

2022-01-21T07:55:18Z

Pharmacology

← Older revision		Revision as of 07:55, 21 January 2022
Line 133:		Line 133:
	*[[Dyspnea]]		*[[Dyspnea]]
	*Contact lens staining		*Contact lens staining

	~~==Pharmacology==~~
	*Half-life: 3-5hr, 2-3hr with repeat dosing
	*Metabolism: Hepatic
	*Excretion: Bile; Urine <30%
	*Mechanism of Action: inhibits bacterial RNA synthesis

	==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==		==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==

Ostermayer: /* General */

2022-01-21T07:54:52Z

General

← Older revision		Revision as of 07:54, 21 January 2022
Line 3:		Line 3:
	*Dosage Forms: 150, 300; PO, IV		*Dosage Forms: 150, 300; PO, IV
	*Common Trade Names: Rifadin		*Common Trade Names: Rifadin
	*Half-life: 1.5-5hours (increased if there is hepatic dysfunction)
	**Rifampin autoinduces its own metabolism so half-life is decreased with subsequent dosing.

	==Adult Dosing==		==Adult Dosing==