SNRI toxicity - Revision history

Danbot: Danbot moved page SNRI Toxicity to SNRI toxicity without leaving a redirect: Naming convention: first word capitalized, subsequent words lowercase

2026-03-22T05:34:41Z

Danbot moved page SNRI Toxicity to SNRI toxicity without leaving a redirect: Naming convention: first word capitalized, subsequent words lowercase

← Older revision	Revision as of 05:34, 22 March 2026
(No difference)

Bobzmac: /* Management */

2021-02-15T19:08:09Z

Management

← Older revision		Revision as of 19:08, 15 February 2021
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	==Management==		==Management==
	*Cardiac monitoring		*Supportive Care
	*~~Supportive Care:~~ IV fluids for hypotension (norepinephrine if refractory), [[Benzodiapazines]] for seizures		**Cardiac monitoring
	*~~No role for activated charcoal or gastric emptying~~		***[[Sodium bicarbonate]] if widened QRS
	*[[~~Sodium bicarbonate~~]] ~~if widened QRS~~		*** IV fluids for hypotension ([[norepinephrine]] if refractory)
			**[[Benzodiapazines]] for seizures
			**GI Decontamination
			***A single dose of [[activated charcoal]], 1 g/kg (typical adult dose is 50 g), may be given to a patient who presents within one to two hours of ingestion.
			***AC should not be given to patients at risk for aspiration

	==Disposition==		==Disposition==

Bobzmac: /* Clinical Features */

2021-02-15T19:02:27Z

Clinical Features

← Older revision		Revision as of 19:02, 15 February 2021
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	*[[Seizures]]		*[[Seizures]]
	**More common than with [[SSRI toxicity]]		**More common than with [[SSRI toxicity]]
			**Also common with [[venlafaxine]] and [[bupropion]]
	*[[Rhabdomyolysis]]		*[[Rhabdomyolysis]]
	**25% occur without seizures		**25% occur without seizures

Beren85: /* Management */

2019-09-01T14:32:19Z

Management

← Older revision		Revision as of 14:32, 1 September 2019
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	==Management==		==Management==
	*Cardiac monitoring		*Cardiac monitoring
	*Supportive Care: IV fluids for hypotension, [[Benzodiapazines]] for seizures		*Supportive Care: IV fluids for hypotension (norepinephrine if refractory), [[Benzodiapazines]] for seizures
	*~~Consider single dose~~ activated charcoal		*No role for activated charcoal or gastric emptying
			*[[Sodium bicarbonate]] if widened QRS

	==Disposition==		==Disposition==

Beren85: /* Evaluation */

2019-09-01T14:30:42Z

Evaluation

← Older revision		Revision as of 14:30, 1 September 2019
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	==Evaluation==		==Evaluation==
	*Suggestive history with appropriate clinical features		*Suggestive history with appropriate clinical features
			*[[ECG]]
			*Assess for [[rhabdomyolysis]]

	==Management==		==Management==
	*Cardiac monitoring		*Cardiac monitoring

Beren85: /* Clinical Features */

2019-09-01T14:28:15Z

Clinical Features

← Older revision		Revision as of 14:28, 1 September 2019
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	*[[ECG]]		*[[ECG]]
	**Most common abnormality: sinus tachycardia		**Most common abnormality: sinus tachycardia
	**May see QRS widening or QT prolongation		**May see QRS widening, QT prolongation and ventricular dysrhythmias
			*[[Serotonin syndrome]]

	==Evaluation==		==Evaluation==
	*Suggestive history with appropriate clinical features		*Suggestive history with appropriate clinical features

Beren85: /* Background */

2019-09-01T14:26:46Z

Background

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	*Inhibits reuptake of serotonin, norepinephrine and small effect on dopamine		*Inhibits reuptake of serotonin, norepinephrine and small effect on dopamine
	**Examples: [[venlafaxine]], [[duloxetine]]		**Examples: [[venlafaxine]], [[duloxetine]]
	*Adverse effects similar to [[SSRIs]]		*Adverse effects similar to [[SSRIs]], but more dangerous
	*[[Venlafaxine]] (Effexor)		*[[Venlafaxine]] (Effexor)
	**Can produce mild to moderate hypertension		**Can produce mild to moderate hypertension

ClaireLewis: /* Background */

2017-03-28T18:19:45Z

Background

← Older revision		Revision as of 18:19, 28 March 2017
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	==Background==		==Background==
	*Inhibits reuptake of serotonin, norepinephrine and small effect on dopamine		*Inhibits reuptake of serotonin, norepinephrine and small effect on dopamine
	**Examples: venlafaxine, duloxetine		**Examples: [[venlafaxine]], [[duloxetine]]
	*Adverse effects similar to [[SSRIs]]		*Adverse effects similar to [[SSRIs]]
	*Venlafaxine (Effexor)		*[[Venlafaxine]] (Effexor)
	**Can produce mild to moderate hypertension		**Can produce mild to moderate hypertension
	*Duloxetine (Cymbalta)		*[[Duloxetine]] (Cymbalta)
	**Nausea, vomiting, dizziness		**Nausea, vomiting, dizziness

	==Clinical Features==		==Clinical Features==
	*Sympathomimetic: tachycardia, hypertension, diaphoresis, tremor, mydriasis		*Sympathomimetic: tachycardia, hypertension, diaphoresis, tremor, mydriasis

Rossdonaldson1: Text replacement - "ECG" to "ECG"

2016-09-09T14:27:48Z

Text replacement - "*ECG" to "*ECG"

← Older revision		Revision as of 14:27, 9 September 2016
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	*[[Rhabdomyolysis]]		*[[Rhabdomyolysis]]
	**25% occur without seizures		**25% occur without seizures
	*ECG		*[[ECG]]
	**Most common abnormality: sinus tachycardia		**Most common abnormality: sinus tachycardia
	**May see QRS widening or QT prolongation		**May see QRS widening or QT prolongation

Neil.m.young: Text replacement - "==Diagnosis==" to "==Evaluation=="

2016-07-25T23:33:36Z

Text replacement - "==Diagnosis==" to "==Evaluation=="

← Older revision		Revision as of 23:33, 25 July 2016
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	**Most common abnormality: sinus tachycardia		**Most common abnormality: sinus tachycardia
	**May see QRS widening or QT prolongation		**May see QRS widening or QT prolongation
	==~~Diagnosis~~==		==Evaluation==
	*Suggestive history with appropriate clinical features		*Suggestive history with appropriate clinical features
	==Management==		==Management==