Silver toxicity - Revision history

Rossdonaldson1: /* Clinical Features */

2018-08-12T22:40:53Z

Clinical Features

← Older revision		Revision as of 22:40, 12 August 2018
Line 16:		Line 16:
	**Permanent bluish-gray discoloration thought to be due to increased melanin production		**Permanent bluish-gray discoloration thought to be due to increased melanin production

	~~'''~~Significant Toxicity~~'''~~		===Significant Toxicity===
	*Rare		*Rare
	*50 mg IV is considered fatal		*50 mg IV is considered fatal

Rossdonaldson1: /* Differential Diagnosis */

2018-08-12T22:40:24Z

Differential Diagnosis

@@ Line 25: / Line 25: @@
 ==Differential Diagnosis==
-===[[Heavy metal]] toxicity===
+{{Heavy metals list}}
 ==Evaluation==

Rossdonaldson1 at 17:37, 7 August 2018

2018-08-07T17:37:31Z

← Older revision		Revision as of 17:37, 7 August 2018
Line 74:		Line 74:
	Lai Becker M., Burns Ewald M. Silver. In: Goldfrank's Toxicologic Emergencies. 9th Ed. New York: McGraw-Hill; 2011: 1321-1325		Lai Becker M., Burns Ewald M. Silver. In: Goldfrank's Toxicologic Emergencies. 9th Ed. New York: McGraw-Hill; 2011: 1321-1325

	[[Category:Toxicology']]		[[Category:Toxicology]]

Therriac: Created page with "==Background== * Silver exposure is typically seen in workplace environments, herbal supplements, and other products * Exposure is usually topical, but can also include inhala..."

2018-08-01T20:12:56Z

Created page with "==Background== * Silver exposure is typically seen in workplace environments, herbal supplements, and other products * Exposure is usually topical, but can also include inhala..."

New page

==Background==
* Silver exposure is typically seen in workplace environments, herbal supplements, and other products
* Exposure is usually topical, but can also include inhalation, and ingestion
*Common work place environments include
**Silver nitrate manufacturing
***Used in manufacturing mirrors, inks, dyes, germicides, antiseptics, and analytical reagents
*Other possible sources of exposure
**Acupuncture needles
**Silver jewelry
**Herbal supplements
**Silver sulfadiazine

==Clinical Features==
*Typically occur as chronic exposure
*Skin discoloration (Argyria)
**Permanent bluish-gray discoloration thought to be due to increased melanin production

'''Significant Toxicity'''
*Rare
*50 mg IV is considered fatal
*Thought to be related to blockade of Na-K-ATPase
*Pulmonary Edema
*Hemorrhage
*Necrosis of bone marrow, liver, and kidneys

==Differential Diagnosis==
===[[Heavy metal]] toxicity===
*[[Aluminum toxicity]]
*[[Antimony toxicity]]
*[[Arsenic toxicity]]
*[[Barium toxicity]]
*[[Bismuth toxicity]]
*[[Cadmium toxicity]]
*[[Chromium toxicity]]
*[[Cobalt toxicity]]
*[[Copper toxicity]]
*[[Gold toxicity]]
*[[Iron toxicity]]
*[[Lead toxicity]]
*[[Lithium toxicity]]
*[[Manganese toxicity]]
*[[Mercury toxicity]]
*[[Nickel toxicity]]
*[[Phosphorous toxicity]]
*[[Platinum toxicity]]
*[[Selenium toxicity]]
*[[Silver toxicity]]
*[[Thallium toxicity]]
*[[Tin toxicity]]
*[[Zinc toxicity]]

==Evaluation==
*Usually a clinical diagnosis
*Serum and urine levels can be sent
**Serum <1 µg/L (<9 nmol/L)
**Urine (24 hour) <2 µg/L (<18 nmol/L)

==Management==
*Argyria
**Topical hydroquinone 5%
**Sunscreen to prevent further pigmentation
*Silver Ingestion
**Supportive Care
*Silver salt ingestion
**treat as [[caustic ingestion]]
*Burns from silver salt
**treat as chemical [[burns]]

==Disposition==
*Discharge unless shows signs of systemic toxicity

==References==
<references/>
Lai Becker M., Burns Ewald M. Silver. In: Goldfrank's Toxicologic Emergencies. 9th Ed. New York: McGraw-Hill; 2011: 1321-1325

[[Category:Toxicology']]