Sodium bicarbonate - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:56:29Z

Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T17:24:06Z

Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

2026-03-20T16:42:15Z

Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

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 **Can be used to treat [[TCA toxicity|TCA]] and [[ASA toxicity]]
 **Cannot be given as a rapid bolus - give 1 mEq/kg over 15-20 minutes to avoid hypotension
 ==See Also==

2023-09-13T20:28:47Z

Comments

← Older revision		Revision as of 20:28, 13 September 2023
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	==Comments==		==Comments==
	*'''Sodium acetate''' can be used as a substitute for sodium bicarbonate during times of critical shortages<ref>Neavyn MJ,Boyer EW, Bird SB, Babu KM. Sodium Acetate as a Replacement for Sodium Bicarbonate in Medical Toxicology: a Review. J Med Toxicol. 2013;9:250–254.</ref>		*'''Sodium acetate''' can be used as a substitute for sodium bicarbonate during times of critical shortages<ref>Neavyn MJ,Boyer EW, Bird SB, Babu KM. Sodium Acetate as a Replacement for Sodium Bicarbonate in Medical Toxicology: a Review. J Med Toxicol. 2013;9:250–254.</ref>
	**Can be used to treat TCA and ASA toxicity		**Can be used to treat [[TCA toxicity\|TCA]] and [[ASA toxicity]]
	**Cannot be given as a rapid bolus - give 1 mEq/kg over 15-20 minutes to avoid hypotension		**Cannot be given as a rapid bolus - give 1 mEq/kg over 15-20 minutes to avoid hypotension

2023-09-13T20:28:10Z

Serious

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	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
	*Extravasation- [[cellulitis]], tissue necrosis, ulcer		*Extravasation: [[cellulitis]], tissue necrosis, ulcer
	*[[Metabolic alkalosis]]		*[[Metabolic alkalosis]]
	*[[Hypernatremia]] <ref>Aufderheide TP, Martin DR, Olson DW, Aprahamian C, Woo JW, Hendley GE, Hargarten KM, Thompson B. Prehospital bicarbonate use in cardiac arrest: a 3-year experience. Am J Emerg Med. 1992 Jan;10(1):4-7. doi: 10.1016/0735-6757(92)90115-e. PMID: 1736913.</ref>		*[[Hypernatremia]] <ref>Aufderheide TP, Martin DR, Olson DW, Aprahamian C, Woo JW, Hendley GE, Hargarten KM, Thompson B. Prehospital bicarbonate use in cardiac arrest: a 3-year experience. Am J Emerg Med. 1992 Jan;10(1):4-7. doi: 10.1016/0735-6757(92)90115-e. PMID: 1736913.</ref>

2023-09-13T20:28:00Z

Adverse Reactions

← Older revision		Revision as of 20:28, 13 September 2023
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	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
	*Extravasation- cellulitis, tissue necrosis, ulcer		*Extravasation- [[cellulitis]], tissue necrosis, ulcer
	*Metabolic alkalosis		*[[Metabolic alkalosis]]
	*Hypernatremia <ref>Aufderheide TP, Martin DR, Olson DW, Aprahamian C, Woo JW, Hendley GE, Hargarten KM, Thompson B. Prehospital bicarbonate use in cardiac arrest: a 3-year experience. Am J Emerg Med. 1992 Jan;10(1):4-7. doi: 10.1016/0735-6757(92)90115-e. PMID: 1736913.</ref>		*[[Hypernatremia]] <ref>Aufderheide TP, Martin DR, Olson DW, Aprahamian C, Woo JW, Hendley GE, Hargarten KM, Thompson B. Prehospital bicarbonate use in cardiac arrest: a 3-year experience. Am J Emerg Med. 1992 Jan;10(1):4-7. doi: 10.1016/0735-6757(92)90115-e. PMID: 1736913.</ref>

	===Common===		===Common===

2023-09-13T20:27:39Z

Contraindications

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	*Relative:		*Relative:
	**Ongoing chloride loss (vomiting, gastrointestinal suction, with concurrent diuretics that induce hypochloremia)		**Ongoing chloride loss (vomiting, gastrointestinal suction, with concurrent diuretics that induce hypochloremia)
	**DKA with pH > 7.1		**[[DKA]] with pH > 7.1

	==Adverse Reactions==		==Adverse Reactions==

2023-08-24T06:21:50Z

Contraindications

← Older revision		Revision as of 06:21, 24 August 2023
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	*Relative:		*Relative:
	**Ongoing chloride loss (vomiting, gastrointestinal suction, with concurrent diuretics that induce hypochloremia)		**Ongoing chloride loss (vomiting, gastrointestinal suction, with concurrent diuretics that induce hypochloremia)
			**DKA with pH > 7.1

	==Adverse Reactions==		==Adverse Reactions==

2022-10-07T15:12:26Z

Mechanism of Action

← Older revision		Revision as of 15:12, 7 October 2022
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	==Mechanism of Action==		==Mechanism of Action==
			*Bicarbonate reacts with H+ ions to form water & carbon dioxide. It acts as a buffer against acidosis by raising blood pH

	==Comments==		==Comments==

2022-10-07T15:11:51Z

Pharmacology