Sodium thiosulfate - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:56:56Z

Switch SMW query from broadtable to table format for better layout with TOC

← Older revision		Revision as of 21:56, 20 March 2026
Line 62:		Line 62:
	\|?Has Route=Route		\|?Has Route=Route
	\|?Has Population=Population		\|?Has Population=Population
	\|format=~~broadtable~~		\|format=table
	\|headers=plain		\|headers=plain
	\|mainlabel=-		\|mainlabel=-

Danbot: Add Indications by Condition SMW query table

2026-03-20T17:45:39Z

Add Indications by Condition SMW query table

@@ Line 51: / Line 51: @@
 *Whereas the nitrites have adverse effects (induction of [[methemoglobinemia]]), sodium thiosulfate is non-toxic
 **Should avoid nitrites in [[cyanide toxicity]] when [[CO poisoning]] is suspected to avoid lowering oxygen-carrying capacity
 ==See Also==

Elcatracho: /* Comments */

2021-03-05T22:55:51Z

Comments

← Older revision		Revision as of 22:55, 5 March 2021
Line 50:		Line 50:
	==Comments==		==Comments==
	*Whereas the nitrites have adverse effects (induction of [[methemoglobinemia]]), sodium thiosulfate is non-toxic		*Whereas the nitrites have adverse effects (induction of [[methemoglobinemia]]), sodium thiosulfate is non-toxic
	**Should avoid nitrites in cyanide toxicity when CO poisoning is suspected to avoid lowering oxygen-carrying capacity		**Should avoid nitrites in [[cyanide toxicity]] when [[CO poisoning]] is suspected to avoid lowering oxygen-carrying capacity

	==See Also==		==See Also==

Elcatracho: /* Comments */

2021-03-05T22:55:24Z

Comments

← Older revision		Revision as of 22:55, 5 March 2021
Line 49:		Line 49:

	==Comments==		==Comments==
	*Whereas the nitrites have adverse effects (induction of [[methemoglobinemia]], sodium thiosulfate is non-toxic		*Whereas the nitrites have adverse effects (induction of [[methemoglobinemia]]), sodium thiosulfate is non-toxic
			**Should avoid nitrites in cyanide toxicity when CO poisoning is suspected to avoid lowering oxygen-carrying capacity

	==See Also==		==See Also==

Elcatracho: /* Comments */

2021-03-05T22:54:36Z

Comments

← Older revision		Revision as of 22:54, 5 March 2021
Line 49:		Line 49:

	==Comments==		==Comments==
	*Whereas the nitrites have adverse effects, sodium thiosulfate is non-toxic		*Whereas the nitrites have adverse effects (induction of [[methemoglobinemia]], sodium thiosulfate is non-toxic

	==See Also==		==See Also==

ClaireLewis at 16:11, 17 May 2017

2017-05-17T16:11:49Z

← Older revision		Revision as of 16:11, 17 May 2017
Line 1:		Line 1:
	==Administration==		==Administration==
	*Type:		*Type: [[Antidote]]
	*Dosage Forms:		*Dosage Forms:
	*Routes of Administration:		*Routes of Administration: IV
	*Common Trade Names:		*Common Trade Names:

	==Adult Dosing==		==Adult Dosing==
	===[[Cyanide toxicity]]===		===[[Cyanide toxicity]]===
	*Adult: 12.5 g IV		*Adult: 12.5 g IV (after giving [[sodium nitrite]] 300 mg)

	===Prophylaxis during nitroprusside infusion===		===Prophylaxis during nitroprusside infusion===
Line 15:		Line 15:
	===[[Cyanide toxicity]]===		===[[Cyanide toxicity]]===
	*Pediatric: 400 mg/kg IV		*Pediatric: 400 mg/kg IV
			*Per micromedex: 412.5 mg/kg or 7 g/m(2) administered at a rate of 0.625 to 1.25 g/min IV

	===Prophylaxis during nitroprusside infusion===		===Prophylaxis during nitroprusside infusion===
Line 21:		Line 22:
	==Special Populations==		==Special Populations==
	*[[Drug pregnancy categories\|Pregnancy Rating]]: C		*[[Drug pregnancy categories\|Pregnancy Rating]]: C
	*Lactation risk:		*Lactation risk: Infant risk cannot be ruled out
			*Renal dosing: not established
	~~===~~Renal ~~Dosing===~~		*Hepatic dosing: not established
	*Adult:
	*~~Pediatric:~~
	~~===~~Hepatic ~~Dosing===~~
	*Adult:
	*Pediatric:

	==Indications==		==Indications==
Line 45:		Line 41:

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 80 min
	*Metabolism:		*Metabolism: Liver
	*Excretion:		*Excretion: Renal

	==Mechanism of Action==		==Mechanism of Action==
			*Sulfur donor that promotes conversion of cyanide to thiocyanate

	==Comments==		==Comments==
	*Sulfur donor that promotes conversion of cyanide to thiocyanate
	*Whereas the nitrites have adverse effects, sodium thiosulfate is non-toxic		*Whereas the nitrites have adverse effects, sodium thiosulfate is non-toxic

	==See Also==		==See Also==
	*[[Cyanide toxicity]]		*[[Cyanide toxicity]]
			*[[Sodium nitrite]]
	==References==		==References==
	<references/>		<references/>

Rossdonaldson1 at 05:21, 17 May 2017

2017-05-17T05:21:53Z

← Older revision		Revision as of 05:21, 17 May 2017
Line 1:		Line 1:
	==~~Background~~==		==Administration==
	*~~Sulfur donor that promotes conversion~~ of ~~cyanide to thiocyanate~~		*Type:
	*~~Whereas the nitrites have adverse effects,~~ sodium thiosulfate ~~is non-toxic~~		*Dosage Forms:
			*Routes of Administration:
			*Common Trade Names:

			==Adult Dosing==
			===[[Cyanide toxicity]]===
			*Adult: 12.5 g IV

			===Prophylaxis during nitroprusside infusion===
			*Add 10 mg sodium thiosulfate for each 1 mg of nitroprusside

			==Pediatric Dosing==
			===[[Cyanide toxicity]]===
			*Pediatric: 400 mg/kg IV

			===Prophylaxis during nitroprusside infusion===
			*Add 10 mg sodium thiosulfate for each 1 mg of nitroprusside

			==Special Populations==
			*[[Drug pregnancy categories\|Pregnancy Rating]]: C
			*Lactation risk:

			===Renal Dosing===
			*Adult:
			*Pediatric:
			===Hepatic Dosing===
			*Adult:
			*Pediatric:

	==Indications==		==Indications==
Line 9:		Line 36:

	==Contraindications==		==Contraindications==
	*~~None~~		*Allergy to class/drug

			==Adverse Reactions==
			===Serious===

	==~~Adverse Effects~~==		===Common===
	*Burning sensation and muscle cramping from infusion		*Burning sensation and muscle cramping from infusion
	*Pregnancy Category C

	==~~Dosing~~==		==Pharmacology==
	*~~Cyanide Poisoning~~:		*Half-life:
	**Adult: ~~12.5 g IV~~		*Metabolism:
	**Pediatric: ~~400 mg/kg IV~~		*Excretion:
	*~~Prophylaxis during nitroprusside infusion:~~
	**Add 10 mg sodium thiosulfate ~~for each 1 mg of nitroprusside~~		==Mechanism of Action==


			==Comments==
			*Sulfur donor that promotes conversion of cyanide to thiocyanate
			*Whereas the nitrites have adverse effects, sodium thiosulfate is non-toxic

	==See Also==		==See Also==
Line 26:		Line 60:

	==References==		==References==
			<references/>
	*Olson, K. Poisoning and Drug Overdose, 1999.		*Olson, K. Poisoning and Drug Overdose, 1999.
	~~<references/>~~

			[[Category:Pharmacology]]
	[[Category:Toxicology]]		[[Category:Toxicology]]

Rossdonaldson1 at 05:18, 17 May 2017

2017-05-17T05:18:22Z

← Older revision		Revision as of 05:18, 17 May 2017
Line 21:		Line 21:
	*Prophylaxis during nitroprusside infusion:		*Prophylaxis during nitroprusside infusion:
	**Add 10 mg sodium thiosulfate for each 1 mg of nitroprusside		**Add 10 mg sodium thiosulfate for each 1 mg of nitroprusside

			==See Also==
			*[[Cyanide toxicity]]

	==References==		==References==

Rossdonaldson1: /* Indications */

2017-05-17T05:18:01Z

Indications

← Older revision		Revision as of 05:18, 17 May 2017
Line 4:		Line 4:

	==Indications==		==Indications==
	*Acute cyanide ~~poisoning~~		*Acute [[cyanide toxicity]]
	*Smoke inhalation with potential for cyanide exposure		*[[Smoke inhalation]] with potential for cyanide exposure
	*Prophylaxis during nitroprusside infusions		*Prophylaxis during [[nitroprusside]] infusions

	==Contraindications==		==Contraindications==

Zipdoc at 03:55, 7 May 2017

2017-05-07T03:55:28Z

← Older revision		Revision as of 03:55, 7 May 2017
Line 25:		Line 25:
	*Olson, K. Poisoning and Drug Overdose, 1999.		*Olson, K. Poisoning and Drug Overdose, 1999.
	<references/>		<references/>

			[[Category:Toxicology]]