Succinylcholine - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:58:18Z

Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T17:24:59Z

Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

2026-03-20T16:43:06Z

Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

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 *Mechanism of Action: Depolarization of the myoneural junction motor endplate
 *Duration of Action: IV: 4-6 minutes; IM 10-30 minutes
 ==See Also==

2021-02-20T20:03:49Z

2020-11-21T03:51:31Z

Adult Dosing

← Older revision		Revision as of 03:51, 21 November 2020
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	==Adult Dosing==		==Adult Dosing==
	*1.5mg/kg IV		*1.0-1.5mg/kg IV
			*Increase dose in cases of shock
	*4mg/kg IM (in extremis)		*4mg/kg IM (in extremis)

2020-11-21T03:50:03Z

Pharmacology

← Older revision		Revision as of 03:50, 21 November 2020
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	==Pharmacology==		==Pharmacology==
			*Structure of two acetylcholine molecules linked through acetate methyl groups
	*Onset: IV: 30-60 seconds; IM: 2-3 minutes		*Onset: IV: 30-60 seconds; IM: 2-3 minutes
	*Metabolism: Plasma pseudocholinesterase hydrolysis		*Metabolism: Plasma pseudocholinesterase hydrolysis

2020-02-25T03:58:35Z

Contraindications

← Older revision		Revision as of 03:58, 25 February 2020
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	*Neuromuscular diseases, e.g., multiple sclerosis, amyotrophic lateral sclerosis, myasthenia gravis myopathies		*Neuromuscular diseases, e.g., multiple sclerosis, amyotrophic lateral sclerosis, myasthenia gravis myopathies
	*[[Myopathies]]		*[[Myopathies]]
			*spinal cord damage (1 week - 3 months old)
	*History of [[Malignant Hyperthermia]]		*History of [[Malignant Hyperthermia]]
	*Immobilization, including found down with unknown time		*Immobilization, including found down with unknown time

2019-09-23T22:36:24Z

References

2018-12-09T20:07:33Z

Contraindications

← Older revision		Revision as of 20:07, 9 December 2018
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	*Preexisting hyperkalemia		*Preexisting hyperkalemia
	*[[Rhabdomyolysis]]		*[[Rhabdomyolysis]]
	*Burns >5 days old<ref>Gronert GA. "Succinylcholine Hyperkalemia after Burns." Anesthesiology 7 1999, Vol.91, 320.</ref>		*Burns, crush injuries, spinal cord injuries, strokes, and intraabdominal sepsis >5 days old<ref>Gronert GA. "Succinylcholine Hyperkalemia after Burns." Anesthesiology 7 1999, Vol.91, 320.</ref><ref>Marx JA, Hockberger RS, Walls RM, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 8th ed. St. Louis, MO: Elsevier; 2014: 855-871.</ref><ref>Tintinalli JE, Stapczynski JS, Ma OJ, et al, eds. Tintinalli's Emergency Medicine: A Comprehensive Study Guide. 8th ed. New York, NY: McGraw-Hill; 2012: 1620-1621.</ref>
	*Crush injury >~~5 days old~~		*Neuromuscular diseases, e.g., multiple sclerosis, amyotrophic lateral sclerosis, myasthenia gravis myopathies
	*Severe infection > ~~5days old~~		*[[Myopathies]]
	*Neuromuscular diseases (e.g. ~~Myasthenia Gravis)~~, myopathies		*History of [[Malignant Hyperthermia]]
	*[[~~Multiple sclerosis~~]]
	*[[~~ALS~~]]
	*Denervating injuries >72hrs old (stroke, spinal cord injury, etc.)
	*Immobilization, including found down with unknown time		*Immobilization, including found down with unknown time
	*History of [[Malignant Hyperthermia]]
	*Allergy to class/drug		*Allergy to class/drug
	*Tetanus, botulism, and other exotoxin infections		*Tetanus, botulism, and other exotoxin infections

2016-07-29T04:40:07Z

Contraindications

← Older revision		Revision as of 04:40, 29 July 2016
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	*[[Rhabdomyolysis]]		*[[Rhabdomyolysis]]
	*Burns >5 days old<ref>Gronert GA. "Succinylcholine Hyperkalemia after Burns." Anesthesiology 7 1999, Vol.91, 320.</ref>		*Burns >5 days old<ref>Gronert GA. "Succinylcholine Hyperkalemia after Burns." Anesthesiology 7 1999, Vol.91, 320.</ref>
	*Crush injury >5d old		*Crush injury >5 days old
	*Severe infection >5d old		*Severe infection > 5days old
	*Neuromuscular diseases (e.g. Myasthenia Gravis), myopathies		*Neuromuscular diseases (e.g. Myasthenia Gravis), myopathies
	*[[Multiple sclerosis]]		*[[Multiple sclerosis]]

← Older revision		Revision as of 20:03, 20 February 2021
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	*[[Malignant Hyperthermia]]		*[[Malignant Hyperthermia]]
	*[[Critical care quick reference]]		*[[Critical care quick reference]]
			*[[Rocuronium]]

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	==References==		==References==