Sulfonylurea toxicity - Revision history

ClaireLewis: /* Background */

2019-08-25T22:34:55Z

Background

← Older revision		Revision as of 22:34, 25 August 2019
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	==Background==		==Background==
	*Sulfonylureas are a commonly prescribed oral diabetes medication, and include [[glyburide]], glimepiride, glipizide chlorpropamide, tolazamide		*Sulfonylureas are a commonly prescribed oral diabetes medication, and include [[glyburide]], glimepiride, [[glipizide]] chlorpropamide, tolazamide
	*Inhibit potassium efflux from pancreatic beta cells→ increased insulin release		*Inhibit potassium efflux from pancreatic beta cells→ increased insulin release

SLuckettG: /* Disposition */

2019-02-12T14:08:28Z

Disposition

← Older revision		Revision as of 14:08, 12 February 2019
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	==Disposition==		==Disposition==
	*Admit		*Admit
			*Because of prolonged effect, not appropriate to discharge from ED even with normal glucose and patient tolerating PO, as hypoglycaemia may recur over 24h or more

	==See Also==		==See Also==

ClaireLewis: /* Background */

2019-01-27T02:42:58Z

Background

← Older revision		Revision as of 02:42, 27 January 2019
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	==Background==		==Background==
	*Sulfonylureas are a commonly prescribed oral diabetes medication, and include glyburide, glimepiride, glipizide chlorpropamide, tolazamide		*Sulfonylureas are a commonly prescribed oral diabetes medication, and include [[glyburide]], glimepiride, glipizide chlorpropamide, tolazamide
	*Inhibit potassium efflux from pancreatic beta cells→ increased insulin release		*Inhibit potassium efflux from pancreatic beta cells→ increased insulin release

Kxl328 at 20:50, 16 September 2018

2018-09-16T20:50:52Z

← Older revision		Revision as of 20:50, 16 September 2018
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	==Background==		==Background==
	*~~sulfonylureas~~ are a commonly prescribed oral diabetes medication, and include glyburide, glimepiride, glipizide chlorpropamide, tolazamide		*Sulfonylureas are a commonly prescribed oral diabetes medication, and include glyburide, glimepiride, glipizide chlorpropamide, tolazamide
	*~~inhibit~~ potassium efflux from pancreatic beta cells→ increased insulin release		*Inhibit potassium efflux from pancreatic beta cells→ increased insulin release

	==Clinical Features==		==Clinical Features==
	*[[Hypoglycemia]]		*[[Hypoglycemia]]
	**~~can~~ occur at therapeutic doses in renally impaired patients		**Can occur at therapeutic doses in renally impaired patients
	**~~hypoglycemia~~ often prolonged and severe		**Hypoglycemia often prolonged and severe
	**~~onset~~ within 8 hours of ingestion		**Onset within 8 hours of ingestion
	*'''Pediatrics''': one pill can kill!!		*'''Pediatrics''': one pill can kill!!

Lisayee25: /* Evaluation */

2017-05-08T20:11:17Z

Evaluation

← Older revision		Revision as of 20:11, 8 May 2017
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	==Evaluation==		==Evaluation==
	*[[~~hypoglycemia~~]] + known or suspected ingestion		*[[Hypoglycemia]] + known or suspected ingestion
			*BMP, creatinine, decrease in renal clearance may have led to toxicity
			*Serial POC glucose measurements
			*Routine ingestion labs if suspect intentional OD
			**[[Acetaminophen]] and [[salicylate]] levels
			**[[ECG]], look for QRS widening and QTc prolongation

	==Management==		==Management==

Mholtz: Text replacement - "-->" to "→"

2017-02-08T17:21:47Z

Text replacement - "-->" to "→"

← Older revision		Revision as of 17:21, 8 February 2017
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	==Background==		==Background==
	*sulfonylureas are a commonly prescribed oral diabetes medication, and include glyburide, glimepiride, glipizide chlorpropamide, tolazamide		*sulfonylureas are a commonly prescribed oral diabetes medication, and include glyburide, glimepiride, glipizide chlorpropamide, tolazamide
	*inhibit potassium efflux from pancreatic beta ~~cells-->~~ increased insulin release		*inhibit potassium efflux from pancreatic beta cells→ increased insulin release

	==Clinical Features==		==Clinical Features==

Rossdonaldson1: Text replacement - "Hypoglycemia" to "Hypoglycemia"

2016-09-24T12:31:07Z

Text replacement - "*Hypoglycemia" to "*Hypoglycemia"

← Older revision		Revision as of 12:31, 24 September 2016
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	==Clinical Features==		==Clinical Features==
	*Hypoglycemia		*[[Hypoglycemia]]
	**can occur at therapeutic doses in renally impaired patients		**can occur at therapeutic doses in renally impaired patients
	**hypoglycemia often prolonged and severe		**hypoglycemia often prolonged and severe

Neil.m.young: Text replacement - "==Diagnosis==" to "==Evaluation=="

2016-07-25T18:28:29Z

Text replacement - "==Diagnosis==" to "==Evaluation=="

← Older revision		Revision as of 18:28, 25 July 2016
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	{{Hypoglycemia DDX}}		{{Hypoglycemia DDX}}

	==~~Diagnosis~~==		==Evaluation==
	*[[hypoglycemia]] + known or suspected ingestion		*[[hypoglycemia]] + known or suspected ingestion

Rossdonaldson1: /* Disposition */

2016-07-12T05:07:22Z

Disposition

← Older revision		Revision as of 05:07, 12 July 2016
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	==Disposition==		==Disposition==
			*Admit

	==See Also==		==See Also==

Rossdonaldson1: /* Diagnosis */

2016-07-11T21:19:35Z

Diagnosis

← Older revision		Revision as of 21:19, 11 July 2016
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	==Diagnosis==		==Diagnosis==
	*hypoglycemia + known or suspected ingestion		*[[hypoglycemia]] + known or suspected ingestion

	==Management==		==Management==

Sulfonylurea toxicity - Revision history

ClaireLewis: /* Background */

SLuckettG: /* Disposition */

ClaireLewis: /* Background */

Kxl328 at 20:50, 16 September 2018

Lisayee25: /* Evaluation */

Mholtz: Text replacement - "-->" to "→"

Rossdonaldson1: Text replacement - "*Hypoglycemia" to "*Hypoglycemia"

Neil.m.young: Text replacement - "==Diagnosis==" to "==Evaluation=="

Rossdonaldson1: /* Disposition */

Rossdonaldson1: /* Diagnosis */

Rossdonaldson1: Text replacement - "Hypoglycemia" to "Hypoglycemia"