Tetrodotoxin - Revision history

Rossdonaldson1: /* Video */

2024-03-27T22:45:27Z

Video

← Older revision		Revision as of 22:45, 27 March 2024
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	==References==		==References==
	<references/>		<references/>

	~~==Video==~~
	~~{{#widget:YouTube\|id=0DyrwwGQnlI}}~~

	[[Category:Toxicology]]		[[Category:Toxicology]]

2019-03-06T06:42:30Z

← Older revision		Revision as of 06:42, 6 March 2019
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	==Management==		==Management==
	*Supportive care~~, intubate~~ if concern for progressive paralysis		*Supportive care is mainstay of treatment
	*[[Acetylcholinesterase inhibitors]] (e.g. [[neostigmine]])~~<ref>Tintanelli's</ref>~~		*May require intubation if concern for progressive paralysis
			*[[Acetylcholinesterase inhibitors]] (e.g. [[neostigmine]])

	==Disposition==		==Disposition==
	*Admit, may need ICU		*Admit (may need ICU)

			==External Links==


	==See Also==		==See Also==

2019-03-05T03:39:06Z

Mechanism of Injury

← Older revision		Revision as of 03:39, 5 March 2019
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	[[File:Blue-ringed-octopus.jpeg\|thumbnail]]		[[File:Blue-ringed-octopus.jpeg\|thumbnail]]

	==Mechanism of Injury==		===Mechanism of Injury===
	*Tetrodotoxin binds to and blocks fast-gated sodium channels, blocking conduction of nerve signals.		*Tetrodotoxin binds to and blocks fast-gated sodium channels, blocking conduction of nerve signals.

2019-03-04T16:14:55Z

added video summarizing tetrodotoxin

← Older revision		Revision as of 16:14, 4 March 2019
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	**Heat-stable toxin not destroyed by washing, freezing or cooking		**Heat-stable toxin not destroyed by washing, freezing or cooking
	*Blocks neuronal action potential by blocking voltage-gated sodium channels		*Blocks neuronal action potential by blocking voltage-gated sodium channels
	*Consumption of improperly prepared pufferfish responsible for vast majority of human toxicity		*Consumption of improperly prepared pufferfish responsible for vast majority of human toxicity (e.g. fugu restaurants)
	[[File:Blue-ringed-octopus.jpeg\|thumbnail]]		[[File:Blue-ringed-octopus.jpeg\|thumbnail]]

			==Mechanism of Injury==
			*Tetrodotoxin binds to and blocks fast-gated sodium channels, blocking conduction of nerve signals.

	==Clinical Features==		==Clinical Features==
	''Onset of symptoms usually within 30 min to 4 hours after eating pufferfish''		''Onset of symptoms usually within 30 min to 4 hours after eating pufferfish''
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	==Disposition==		==Disposition==
	*Admit, may need ICU		*Admit, may need ICU

	==See Also==		==See Also==
	*[[Marine toxins and envenomations]]		*[[Marine toxins and envenomations]]
	~~==External Links==~~

	==References==		==References==
	<references/>		<references/>

			==Video==
			{{#widget:YouTube\|id=0DyrwwGQnlI}}

	[[Category:Toxicology]]		[[Category:Toxicology]]

2017-10-02T02:07:48Z

← Older revision		Revision as of 02:07, 2 October 2017
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	*Blocks neuronal action potential by blocking voltage-gated sodium channels		*Blocks neuronal action potential by blocking voltage-gated sodium channels
	*Consumption of improperly prepared pufferfish responsible for vast majority of human toxicity		*Consumption of improperly prepared pufferfish responsible for vast majority of human toxicity
			[[File:Blue-ringed-octopus.jpeg\|thumbnail]]
	==Clinical Features==		==Clinical Features==
	''Onset of symptoms usually within 30 min to 4 hours after eating pufferfish''		''Onset of symptoms usually within 30 min to 4 hours after eating pufferfish''

2017-09-11T16:58:42Z

Clinical Features

← Older revision		Revision as of 16:58, 11 September 2017
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	==Clinical Features==		==Clinical Features==
	''Onset of symptoms usually within 30 min to 4 hours after eating pufferfish''		''Onset of symptoms usually within 30 min to 4 hours after eating pufferfish''
	*Paresthesias		*Paresthesias, body numbness
			*Dysarthria, dysphagia
	*[[Headache]]		*[[Headache]]
	*[[Vomiting]], [[diarrhea]], [[abdominal pain]]		*[[Vomiting]], [[diarrhea]], [[abdominal pain]]

2017-09-11T16:56:30Z

Background

← Older revision		Revision as of 16:56, 11 September 2017
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	==Background==		==Background==
	*Neurotoxin found in several marine animals (pufferfish, certain angelfish, blue-ringed octopus)		*Neurotoxin found in several marine animals (pufferfish, certain angelfish, blue-ringed octopus)
			**Heat-stable toxin not destroyed by washing, freezing or cooking
	*Blocks neuronal action potential by blocking voltage-gated sodium channels		*Blocks neuronal action potential by blocking voltage-gated sodium channels
	*Consumption of improperly prepared pufferfish responsible for vast majority of human toxicity		*Consumption of improperly prepared pufferfish responsible for vast majority of human toxicity

2016-10-05T04:58:24Z

Management

← Older revision		Revision as of 04:58, 5 October 2016
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	==Management==		==Management==
	*Supportive care, intubate if concern for progressive paralysis		*Supportive care, intubate if concern for progressive paralysis
	*Acetylcholinesterase inhibitors (e.g. [[neostigmine]])<ref>Tintanelli's</ref>		*[[Acetylcholinesterase inhibitors]] (e.g. [[neostigmine]])<ref>Tintanelli's</ref>

	==Disposition==		==Disposition==
	*Admit, may need ICU		*Admit, may need ICU

2016-09-08T08:39:18Z

Differential Diagnosis

2016-09-07T23:13:20Z