Tigecycline - Revision history

Ostermayer at 15:15, 18 July 2025

2025-07-18T15:15:37Z

← Older revision		Revision as of 15:15, 18 July 2025
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	==General==		==General==
	*Type: [[Glycylcycline]] ([[Tetracyclines]])		*Type: [[Glycylcycline]] ([[Is DrugClass::Tetracyclines]])
	*Dosage Forms: IV		*Dosage Forms: IV
	*Common Trade Names: Tygacil		*Common Trade Names: Tygacil

ClaireLewis: /* References */

2019-09-23T23:01:02Z

References

← Older revision		Revision as of 23:01, 23 September 2019
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	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:ID]]

ClaireLewis: /* Special Populations */

2019-09-23T23:00:49Z

Special Populations

← Older revision		Revision as of 23:00, 23 September 2019
Line 37:		Line 37:

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Drug rating in pregnancy]]:		*[[Drug Ratings in Pregnancy\|Drug rating in pregnancy]]: D
	*[[Lactation_risk_categories\|Lactation risk category]]: Possibly Unsafe; consider alternatives		*[[Lactation_risk_categories\|Lactation risk category]]: Possibly Unsafe; consider alternatives
	*Renal Dosing		*Renal Dosing
Line 47:		Line 47:
	**Pediatric:		**Pediatric:
	***Not defined, but may be required. See adult dosing.		***Not defined, but may be required. See adult dosing.


	==Contraindications==		==Contraindications==

Mholtz at 23:29, 30 August 2017

2017-08-30T23:29:16Z

← Older revision		Revision as of 23:29, 30 August 2017
Line 223:		Line 223:
	===Key===		===Key===
	{{Template:Antibacterial Spectra Key}}		{{Template:Antibacterial Spectra Key}}

	==See Also==		==See Also==
	*[[Antibiotics (Main)]]		*[[Antibiotics (Main)]]

	==~~Source~~==		==References==

	<references/>		<references/>

	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Jonwarren: Updated dosing and pharmacology

2017-08-14T15:35:10Z

Updated dosing and pharmacology

← Older revision		Revision as of 15:35, 14 August 2017
Line 1:		Line 1:
	==General==		==General==
	*Type: [[Glycylcycline]] ([[Tetracyclines]])		*Type: [[Glycylcycline]] ([[Tetracyclines]])
	*Dosage Forms:		*Dosage Forms: IV
	*Common Trade Names: Tygacil		*Common Trade Names: Tygacil

	==Adult Dosing==		==Adult Dosing==
	===~~General~~ Infections===		===Intra-Abdominal Infections===
	*		*50mg IV q12h x5-14 days
			**Start: 100mg IV x1
			===Skin Infections, complicated===
			*50mg IV q12h x5-14 days
			**Start: 100mg IV x1
			===[[Pneumonia]], Community acquired===
			*50mg IV q12h for at least 5 days
			**Start 100mg IV x1
			**May D/C after 5 days if afebrile 48-72h

	==Pediatric Dosing==		==Pediatric Dosing==
	===~~General~~ Infections===		===Intra-abdominal Infections===
	*		*8-11yo
			**1.2 mg/kg IV q12h
			**Max: 50 mg/12h
			*12-17 yo
			**50mg IV 112h
			===Skin Infections, complicated===
			*8-11yo
			**1.2 mg/kg IV q12h
			**Max: 50 mg/12h
			*12-17 yo
			**50mg IV 112h
			===[[Pneumonia]], Community Acquired===
			*8-11yo
			**1.2 mg/kg IV q12h
			**Max: 50 mg/12h
			*12-17 yo
			**50mg IV 112h

	==Special Populations==		==Special Populations==
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	*[[Lactation_risk_categories\|Lactation risk category]]: Possibly Unsafe; consider alternatives		*[[Lactation_risk_categories\|Lactation risk category]]: Possibly Unsafe; consider alternatives
	*Renal Dosing		*Renal Dosing
	**Adult:		**Adult: No adjustment
	**Pediatric:		**Pediatric: No adjustment
	*Hepatic Dosing		*Hepatic Dosing
	**Adult:		**Adult:
			***Child-Pugh Class C: Decrease maintenance dose 50%
	**Pediatric:		**Pediatric:
	*		***Not defined, but may be required. See adult dosing.


	==Contraindications==		==Contraindications==
Line 27:		Line 53:
	*Pregnancy		*Pregnancy
	*Age <8 years		*Age <8 years
			*Hospital-acquired pneumonia
			*Diabetic foot infection
	*Caution:		*Caution:
	**Child bearing potential		**Child bearing potential
	**		**Hepatic impairment
	*

	==Adverse Reactions==		==Adverse Reactions==
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	*Jarisch-Herxheimer reaction		*Jarisch-Herxheimer reaction
	*Fetal harm		*Fetal harm
	*

	===Common===		===Common===
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	*Skin discoloration		*Skin discoloration
	*Elevated BUN		*Elevated BUN
	*

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: Unknown
	*Metabolism:		*Metabolism: Minimal
	*Excretion: ~~Feces and urine~~		*Excretion: Bile/feces - 59%; Urine 33%
	*Mechanism of Action: Bacteriostatic		*Mechanism of Action: Bacteriostatic

Rossdonaldson1: Text replacement - "Diarrhea" to "Diarrhea"

2016-09-24T11:08:43Z

Text replacement - "*Diarrhea" to "*Diarrhea"

← Older revision		Revision as of 11:08, 24 September 2016
Line 59:		Line 59:
	*Dyspepsia		*Dyspepsia
	*Arthralgia		*Arthralgia
	*Diarrhea		*[[Diarrhea]]
	*Rash		*Rash
	*Dysmenorrhea		*Dysmenorrhea

Cheejyg at 12:31, 30 March 2016

2016-03-30T12:31:54Z

← Older revision		Revision as of 12:31, 30 March 2016
Line 14:		Line 14:
	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Drug rating in pregnancy]]:		*[[Drug Ratings in Pregnancy\|Drug rating in pregnancy]]:
	*[[Lactation_risk_categories\|Lactation risk category]]~~: Lactation~~: Possibly Unsafe; consider alternatives		*[[Lactation_risk_categories\|Lactation risk category]]: Possibly Unsafe; consider alternatives
	*Renal Dosing		*Renal Dosing
	**Adult:		**Adult:
Line 52:		Line 52:
	*Jarisch-Herxheimer reaction		*Jarisch-Herxheimer reaction
	*Fetal harm		*Fetal harm
			*

	===Common===		===Common===
Line 65:		Line 66:
	*Skin discoloration		*Skin discoloration
	*Elevated BUN		*Elevated BUN
			*

	==Pharmacology==		==Pharmacology==
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	{{Template:Antibacterial Spectra Key}}		{{Template:Antibacterial Spectra Key}}
	==See Also==		==See Also==
			*[[Antibiotics (Main)]]

	==Source==		==Source==

Cheejyg at 12:26, 30 March 2016

2016-03-30T12:26:15Z

← Older revision		Revision as of 12:26, 30 March 2016
Line 1:		Line 1:
	==General==		==General==
	*Type:		*Type: [[Glycylcycline]] ([[Tetracyclines]])
	*Dosage Forms:		*Dosage Forms:
	*Common Trade Names:		*Common Trade Names: Tygacil

	==Adult Dosing==		==Adult Dosing==
			===General Infections===
			*

	==Pediatric Dosing==		==Pediatric Dosing==
			===General Infections===
			*

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|~~Pregnancy Rating~~]]:		*[[Drug Ratings in Pregnancy\|Drug rating in pregnancy]]:
	*Lactation:		*[[Lactation_risk_categories\|Lactation risk category]]: Lactation: Possibly Unsafe; consider alternatives
	*Renal Dosing		*Renal Dosing
	**Adult		**Adult:
	**Pediatric		**Pediatric:
	*Hepatic Dosing		*Hepatic Dosing
	**Adult		**Adult:
	**Pediatric		**Pediatric:
			*

	==Contraindications==		==Contraindications==
	*Allergy to class/drug		*Allergy to class/drug
			*Pregnancy
			*Age <8 years
			*Caution:
			**Child bearing potential
			**
			*

	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
			*Tooth discoloration children <8 years old
			*Photosensitivity
			*Hypersensitivity reaction
			*Skin reaction
			*Vasculitis
			*Pericarditis
			*Autoimmune hepatitis
			*Hepatotoxicity
			*Nephrotoxicity
			*Esophagitis/ulcer
			*[[Pancreatitis]]
			*[[Thrombocytopenia]]
			*[[Neutropenia]]
			*Hemolytic anemia
			*[[Pseudotumor cerebri]]
			*Bulging fontanelles
			*Jarisch-Herxheimer reaction
			*Fetal harm

	===Common===		===Common===
			*Headache
			*Nausea
			*Dyspepsia
			*Arthralgia
			*Diarrhea
			*Rash
			*Dysmenorrhea
			*Photosensitivity
			*Vulvovaginal candidiasis
			*Skin discoloration
			*Elevated BUN

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life:
	*Metabolism:		*Metabolism:
	*Excretion:		*Excretion: Feces and urine
	*Mechanism of Action:		*Mechanism of Action: Bacteriostatic

	==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==		==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==

Ostermayer: Text replacement - "Category:Drugs" to "Category:Pharmacology"

2016-03-22T15:54:44Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"

← Older revision		Revision as of 15:54, 22 March 2016
Line 159:		Line 159:
	<references/>		<references/>

	[[Category:~~Drugs~~]]		[[Category:Pharmacology]]

Rossdonaldson1: /* Source */

2014-09-30T13:37:03Z

Source

← Older revision		Revision as of 13:37, 30 September 2014
Line 158:		Line 158:

	<references/>		<references/>

			[[Category:Drugs]]