Valproate - Revision history

Elcatracho: /* See Also */

2021-02-22T22:30:30Z

Elcatracho: /* See Also */

2021-02-20T19:14:18Z

ClaireLewis: /* References */

2019-09-23T23:23:37Z

References

← Older revision		Revision as of 23:23, 23 September 2019
Line 76:		Line 76:

	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:Neurology]]

ClaireLewis at 15:18, 22 August 2017

2017-08-22T15:18:56Z

← Older revision		Revision as of 15:18, 22 August 2017
Line 16:		Line 16:
	**Maintenance: 1-5mg/kg/hr		**Maintenance: 1-5mg/kg/hr

	===[[~~Mania~~]]===		===[[Bipolar disorder]], manic episode===
	*Oral: Depakote Stavzor 750mg/d or Depakote ER 25mg/kg/d qday		*Oral: Depakote Stavzor 750mg/d or Depakote ER 25mg/kg/d qday

Line 50:		Line 50:
	*[[Headache]], drowsiness, dizziness, insomnia, nervousness, pain		*[[Headache]], drowsiness, dizziness, insomnia, nervousness, pain
	*[[Alopecia]]		*[[Alopecia]]
	*[[Nausea]], [[vomiting]], [[diarrhea]], [[abdominal pain]], [[anorexia]]		*[[Nausea]], [[vomiting]], [[diarrhea]], [[abdominal pain]], anorexia
	*[[Thrombocytopenia]]		*[[Thrombocytopenia]]
	*Infection		*Infection
	*[[Tremor]], [[weakness]]		*Tremor, [[weakness]]
	*[[Diplopia]], visual disturbance		*[[Diplopia]], visual disturbance
	*[[Flu-like symptoms]]		*[[Flu-like symptoms]]

Rossdonaldson1: Text replacement - "Pancreatitis" to "Pancreatitis"

2016-09-25T20:23:16Z

Text replacement - "*Pancreatitis" to "*Pancreatitis"

← Older revision		Revision as of 20:23, 25 September 2016
Line 45:		Line 45:
	*Hepatotoxicity		*Hepatotoxicity
	*Congenital malformation: neural tube defect		*Congenital malformation: neural tube defect
	*Pancreatitis		*[[Pancreatitis]]

	===Common===		===Common===

Neil.m.young: Text replacement - "0 mg" to "0mg"

2016-07-21T02:19:47Z

Text replacement - "0 mg" to "0mg"

← Older revision		Revision as of 02:19, 21 July 2016
Line 59:		Line 59:
	==Toxicity==		==Toxicity==
	*Potential use for early IV L-carnitine to reduce hepatotoxicity		*Potential use for early IV L-carnitine to reduce hepatotoxicity
	*~~100 mg~~/kg IV once, followed by ~~50 mg~~/kg (max 3 g per dose) q8hrs until ammonia levels normalize<ref>Perott J et al. L-carnitine for acute valproic acid overdose: a systematic review of published cases. Ann Pharmacother. 2010 Jul-Aug;44(7-8):1287-93. doi: 10.1345/aph.1P135. Epub 2010 Jun 29.</ref>		*100mg/kg IV once, followed by 50mg/kg (max 3 g per dose) q8hrs until ammonia levels normalize<ref>Perott J et al. L-carnitine for acute valproic acid overdose: a systematic review of published cases. Ann Pharmacother. 2010 Jul-Aug;44(7-8):1287-93. doi: 10.1345/aph.1P135. Epub 2010 Jun 29.</ref>

	==Pharmacology==		==Pharmacology==

Neil.m.young: Text replacement - "* " to "*"

2016-07-09T20:30:42Z

Text replacement - "* " to "*"

← Older revision		Revision as of 20:30, 9 July 2016
Line 6:		Line 6:
	==Adult Dosing==		==Adult Dosing==
	===[[Seizures]]===		===[[Seizures]]===
	* Oral (max 60mg/kg/d)		*Oral (max 60mg/kg/d)
	** Simple/complex absence: Initial 15mg/kg/d; increase 5-10mg/kg/d at weekly until therapeutic		**Simple/complex absence: Initial 15mg/kg/d; increase 5-10mg/kg/d at weekly until therapeutic
	** Complex partial: Initial 10-15mg/kg/d; increase 5-10mg/kg/d at weekly until therapeutic		**Complex partial: Initial 10-15mg/kg/d; increase 5-10mg/kg/d at weekly until therapeutic
	*** Extended release formulation given once daily		***Extended release formulation given once daily
	*IV: same dose as oral, administered as 60min infusion		*IV: same dose as oral, administered as 60min infusion

Line 20:		Line 20:

	===[[Migraine]] prophlyaxis===		===[[Migraine]] prophlyaxis===
	* Oral: Depakote, Stavzor 250mg BID or Depakote ER 500mg qday		*Oral: Depakote, Stavzor 250mg BID or Depakote ER 500mg qday

	==Pediatric Dosing==		==Pediatric Dosing==

Ostermayer: Text replacement - "Category:Drugs" to "Category:Pharmacology"

2016-03-22T15:54:34Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"

← Older revision		Revision as of 15:54, 22 March 2016
Line 75:		Line 75:
	<references/>		<references/>

	[[Category:~~Drugs~~]]		[[Category:Pharmacology]]

Rossdonaldson1 at 15:39, 14 September 2015

2015-09-14T15:39:11Z

← Older revision		Revision as of 15:39, 14 September 2015
Line 5:		Line 5:

	==Adult Dosing==		==Adult Dosing==
	*Seizures		===[[Seizures]]===
	** Oral (max 60mg/kg/d)		* Oral (max 60mg/kg/d)
	*** Simple/complex absence: Initial 15mg/kg/d; increase 5-10mg/kg/d at weekly until therapeutic		** Simple/complex absence: Initial 15mg/kg/d; increase 5-10mg/kg/d at weekly until therapeutic
	*** Complex partial: Initial 10-15mg/kg/d; increase 5-10mg/kg/d at weekly until therapeutic		** Complex partial: Initial 10-15mg/kg/d; increase 5-10mg/kg/d at weekly until therapeutic
	**** Extended release formulation given once daily		*** Extended release formulation given once daily
	**IV: same dose as oral, administered as 60min infusion		*IV: same dose as oral, administered as 60min infusion
	* Status epilepticus, refractory
	**IV: Loading 15-20mg/kg administered at 20mg/min		===[[Status epilepticus]], refractory===
	***Maintenance: 1-5mg/kg/hr		*IV: Loading 15-20mg/kg administered at 20mg/min
	*Mania		**Maintenance: 1-5mg/kg/hr
	**Oral: Depakote Stavzor 750mg/d or Depakote ER 25mg/kg/d qday
	*Migraine prophlyaxis		===[[Mania]]===
	** Oral: Depakote, Stavzor 250mg BID or Depakote ER 500mg qday		*Oral: Depakote Stavzor 750mg/d or Depakote ER 25mg/kg/d qday

			===[[Migraine]] prophlyaxis===
			* Oral: Depakote, Stavzor 250mg BID or Depakote ER 500mg qday

	==Pediatric Dosing==		==Pediatric Dosing==
	*Same as adult dosing		*Same as adult dosing
	*Avoid extended release formulation in children <10yr		*Avoid extended release formulation in children <10yr

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: X		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: X
Line 32:		Line 37:
	*Allergy to class/drug		*Allergy to class/drug
	*Severe hepatic impairment		*Severe hepatic impairment
	*Pregnancy		*[[Pregnancy]]
	*Urea cycle disorders		*Urea cycle disorders
	*Mitochondrial disorders		*Mitochondrial disorders

	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
Line 40:		Line 46:
	*Congenital malformation: neural tube defect		*Congenital malformation: neural tube defect
	*Pancreatitis		*Pancreatitis

	===Common===		===Common===
	*Headache, drowsiness, dizziness, insomnia, nervousness, pain		*[[Headache]], drowsiness, dizziness, insomnia, nervousness, pain
	*Alopecia		*[[Alopecia]]
	*Nausea, vomiting, diarrhea, abdominal pain, anorexia		*[[Nausea]], [[vomiting]], [[diarrhea]], [[abdominal pain]], [[anorexia]]
	*Thrombocytopenia		*[[Thrombocytopenia]]
	*Infection		*Infection
	*Tremor, weakness		*[[Tremor]], [[weakness]]
	*Diplopia, visual disturbance		*[[Diplopia]], visual disturbance
	*Flu-like symptoms		*[[Flu-like symptoms]]

	==Toxicity==		==Toxicity==
Line 65:		Line 72:
	*[[Seizure]]		*[[Seizure]]

	==~~Sources~~==		==References==
			<references/>

	~~<references/>~~
	*UpToDate
	[[Category:Drugs]]		[[Category:Drugs]]

Kxl328 at 13:08, 14 September 2015

2015-09-14T13:08:26Z

← Older revision		Revision as of 13:08, 14 September 2015
Line 52:		Line 52:
	==Toxicity==		==Toxicity==
	*Potential use for early IV L-carnitine to reduce hepatotoxicity		*Potential use for early IV L-carnitine to reduce hepatotoxicity
	*100 mg/kg IV once, followed by 50 mg/kg (max 3 g per dose) q8hrs until ammonia levels normalize</ref>Perott J et al. L-carnitine for acute valproic acid overdose: a systematic review of published cases. Ann Pharmacother. 2010 Jul-Aug;44(7-8):1287-93. doi: 10.1345/aph.1P135. Epub 2010 Jun 29.<ref>		*100 mg/kg IV once, followed by 50 mg/kg (max 3 g per dose) q8hrs until ammonia levels normalize<ref>Perott J et al. L-carnitine for acute valproic acid overdose: a systematic review of published cases. Ann Pharmacother. 2010 Jul-Aug;44(7-8):1287-93. doi: 10.1345/aph.1P135. Epub 2010 Jun 29.</ref>

	==Pharmacology==		==Pharmacology==

← Older revision		Revision as of 19:14, 20 February 2021
Line 71:		Line 71:
	==See Also==		==See Also==
	*[[Seizure]]		*[[Seizure]]
			*[[Valproic acid toxicity]]

	==References==		==References==

← Older revision		Revision as of 22:30, 22 February 2021
Line 72:		Line 72:
	*[[Seizure]]		*[[Seizure]]
	*[[Valproic acid toxicity]]		*[[Valproic acid toxicity]]
			*[[Valproic acid]]

	==References==		==References==

Valproate - Revision history

Elcatracho: /* See Also */

Elcatracho: /* See Also */

ClaireLewis: /* References */

ClaireLewis at 15:18, 22 August 2017

Rossdonaldson1: Text replacement - "*Pancreatitis" to "*Pancreatitis"

Neil.m.young: Text replacement - "0 mg" to "0mg"

Neil.m.young: Text replacement - "* " to "*"

Ostermayer: Text replacement - "Category:Drugs" to "Category:Pharmacology"

Rossdonaldson1 at 15:39, 14 September 2015

Kxl328 at 13:08, 14 September 2015

Rossdonaldson1: Text replacement - "Pancreatitis" to "Pancreatitis"