Valproic acid - Revision history

Danbot: Remove refs with incorrect PMIDs (verified against PubMed)

2026-03-22T10:26:47Z

Remove refs with incorrect PMIDs (verified against PubMed)

← Older revision		Revision as of 10:26, 22 March 2026
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	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
	*Hepatotoxicity~~<ref>Gerstner T, et al. Valproic acid-induced hepatotoxicity. Drug Saf. 2007;30(12):1049-1060. PMID 18035612</ref>~~		*Hepatotoxicity
	*[[Pancreatitis]]		*[[Pancreatitis]]
	*SIADH		*SIADH

Danbot: Add reference

2026-03-22T10:06:48Z

Add reference

← Older revision		Revision as of 10:06, 22 March 2026
Line 67:		Line 67:
	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
	*Hepatotoxicity		*Hepatotoxicity<ref>Gerstner T, et al. Valproic acid-induced hepatotoxicity. Drug Saf. 2007;30(12):1049-1060. PMID 18035612</ref>
	*[[Pancreatitis]]		*[[Pancreatitis]]
	*SIADH		*SIADH

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:58:28Z

Switch SMW query from broadtable to table format for better layout with TOC

← Older revision		Revision as of 21:58, 20 March 2026
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	\|?Has Route=Route		\|?Has Route=Route
	\|?Has Population=Population		\|?Has Population=Population
	\|format=~~broadtable~~		\|format=table
	\|headers=plain		\|headers=plain
	\|mainlabel=-		\|mainlabel=-

Danbot: Add MedicationDose SMW query table for dynamic indications by condition

2026-03-20T20:36:47Z

Add MedicationDose SMW query table for dynamic indications by condition

@@ Line 97: / Line 97: @@
 ==Mechanism of Action==
 *Increases GABA effects, may inhibit glutamate/NMDA receptor-mediated neuronal excitation
 ==See also==

Elcatracho: /* Mechanism of Action */

2021-02-20T19:19:16Z

Mechanism of Action

← Older revision		Revision as of 19:19, 20 February 2021
Line 97:		Line 97:
	==Mechanism of Action==		==Mechanism of Action==
	*Increases GABA effects, may inhibit glutamate/NMDA receptor-mediated neuronal excitation		*Increases GABA effects, may inhibit glutamate/NMDA receptor-mediated neuronal excitation

			==See also==
			*[[Valproate]]
			*[[Valproic acid toxicity]]

	==References==		==References==

ClaireLewis: /* Administration */

2019-09-29T16:21:00Z

Administration

← Older revision		Revision as of 16:21, 29 September 2019
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	==Administration==		==Administration==
	*Type: Anticonvulsant		*Type: [[Anticonvulsant]]
	*Dosage Forms: 250mg, 250/5 mL		*Dosage Forms: 250mg, 250/5 mL
	*Routes of Administration: Oral, IV		*Routes of Administration: Oral, IV

ClaireLewis: /* References */

2019-09-23T23:24:35Z

References

← Older revision		Revision as of 23:24, 23 September 2019
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	<UptoDate, epocrates>		<UptoDate, epocrates>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:Neurology]]

Mholtz: Text replacement - "qd" to "QD"

2017-07-07T11:41:00Z

Text replacement - "qd" to "QD"

← Older revision		Revision as of 11:41, 7 July 2017
Line 7:		Line 7:
	==Adult Dosing==		==Adult Dosing==
	*Complex partial seizures: 30-60mg/kg/day PO (divided bid-tid)		*Complex partial seizures: 30-60mg/kg/day PO (divided bid-tid)
	**Start: 10-15mg/kg/day PO divided qd-tid		**Start: 10-15mg/kg/day PO divided QD-tid
	**Increase by 5-10mg/kg/day q7 days		**Increase by 5-10mg/kg/day q7 days
	**Max: 60mg/kg/day		**Max: 60mg/kg/day
Line 19:		Line 19:

	*Absence seizures, simple and complex: 30-60mg/kg/day PO (divided bid-tid)		*Absence seizures, simple and complex: 30-60mg/kg/day PO (divided bid-tid)
	**Start: 15mg/kg/day PO divided qd-tid, increase by 5-10mg/kg/day every 7 days		**Start: 15mg/kg/day PO divided QD-tid, increase by 5-10mg/kg/day every 7 days
	**Max: 60mg/kg/day		**Max: 60mg/kg/day

Line 36:		Line 36:
	==Pediatric Dosing==		==Pediatric Dosing==
	*Partial seizures, complex: 30-60mg/kg/day PO divided bid-tid		*Partial seizures, complex: 30-60mg/kg/day PO divided bid-tid
	**Start: 10-15mg/kg/day PO divided qd-tid,		**Start: 10-15mg/kg/day PO divided QD-tid,
	**Increase by 5-10mg/kg/day q7 days; Max: 60mg/kg/day;		**Increase by 5-10mg/kg/day q7 days; Max: 60mg/kg/day;
	**Adjust dose based on treatment response and serum levels		**Adjust dose based on treatment response and serum levels
Line 42:		Line 42:

	*Absence seizures, simple and complex: 30-60mg/kg/day PO divided bid-tid		*Absence seizures, simple and complex: 30-60mg/kg/day PO divided bid-tid
	**Start: 15mg/kg/day PO divided qd-tid		**Start: 15mg/kg/day PO divided QD-tid
	**Increase by 5-10mg/kg/day q7 days		**Increase by 5-10mg/kg/day q7 days
	**Max: 60mg/kg/day		**Max: 60mg/kg/day

Neil.m.young: Text replacement - "0 mg" to "0mg"

2016-07-26T18:55:50Z

Text replacement - "0 mg" to "0mg"

← Older revision		Revision as of 18:55, 26 July 2016
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	==Adult Dosing==		==Adult Dosing==
	*Complex partial seizures: 30-~~60 mg~~/kg/day PO (divided bid-tid)		*Complex partial seizures: 30-60mg/kg/day PO (divided bid-tid)
	**Start: 10-15mg/kg/day PO divided qd-tid		**Start: 10-15mg/kg/day PO divided qd-tid
	**Increase by 5-~~10 mg~~/kg/day q7 days		**Increase by 5-10mg/kg/day q7 days
	**Max: ~~60 mg~~/kg/day		**Max: 60mg/kg/day
	**Decrease start dose and titrate slowly in elderly patients		**Decrease start dose and titrate slowly in elderly patients
	**Adjust dose based on treatment response and serum levels		**Adjust dose based on treatment response and serum levels
	**Divide doses >~~250 mg~~/day		**Divide doses >250mg/day
	**Do not cut/crush/chew with outpen caps		**Do not cut/crush/chew with outpen caps
	**Taper dose gradually to discontinue		**Taper dose gradually to discontinue
	**Total daily IV dose should equal total oral daily dose		**Total daily IV dose should equal total oral daily dose
	**Administer IV dose as a 60-minute infusion (~~≤20 mg~~/minute)		**Administer IV dose as a 60-minute infusion (≤20mg/minute)

	*Absence seizures, simple and complex: 30-~~60 mg~~/kg/day PO (divided bid-tid)		*Absence seizures, simple and complex: 30-60mg/kg/day PO (divided bid-tid)
	**Start: 15mg/kg/day PO divided qd-tid, increase by 5-~~10 mg~~/kg/day every 7 days		**Start: 15mg/kg/day PO divided qd-tid, increase by 5-10mg/kg/day every 7 days
	**Max: ~~60 mg~~/kg/day		**Max: 60mg/kg/day

	*Bipolar disorder, acute mania: 250-~~500 mg~~ PO tid		*Bipolar disorder, acute mania: 250-500mg PO tid
	**Start: ~~250 mg~~ PO tid, may increase dose rapidly to lowest effective dose		**Start: 250mg PO tid, may increase dose rapidly to lowest effective dose
	**Max: ~~60 mg~~/kg/day		**Max: 60mg/kg/day
	**Decrease start dose and titrate slowly in elderly patients		**Decrease start dose and titrate slowly in elderly patients

	*Migraine headache prophylaxis: 250-~~500 mg~~ PO bid		*Migraine headache prophylaxis: 250-500mg PO bid
	**Start: ~~250 mg~~ PO bid		**Start: 250mg PO bid

	*Status epilepticus (off-label use): IV loading dose: 20 to ~~40 mg~~/kg		*Status epilepticus (off-label use): IV loading dose: 20 to 40mg/kg
	**Administer at rate of 3 to 6mg/kg/min		**Administer at rate of 3 to 6mg/kg/min
	**May give an additional dose of ~~20 mg~~/kg 10 minutes after the loading infusion		**May give an additional dose of 20mg/kg 10 minutes after the loading infusion

	==Pediatric Dosing==		==Pediatric Dosing==
	*Partial seizures, complex: 30-~~60 mg~~/kg/day PO divided bid-tid		*Partial seizures, complex: 30-60mg/kg/day PO divided bid-tid
	**Start: 10-15mg/kg/day PO divided qd-tid,		**Start: 10-15mg/kg/day PO divided qd-tid,
	**Increase by 5-~~10 mg~~/kg/day q7 days; Max: ~~60 mg~~/kg/day;		**Increase by 5-10mg/kg/day q7 days; Max: 60mg/kg/day;
	**Adjust dose based on treatment response and serum levels		**Adjust dose based on treatment response and serum levels
	**Not recommended under age 10		**Not recommended under age 10

	*Absence seizures, simple and complex: 30-~~60 mg~~/kg/day PO divided bid-tid		*Absence seizures, simple and complex: 30-60mg/kg/day PO divided bid-tid
	**Start: 15mg/kg/day PO divided qd-tid		**Start: 15mg/kg/day PO divided qd-tid
	**Increase by 5-~~10 mg~~/kg/day q7 days		**Increase by 5-10mg/kg/day q7 days
	**Max: ~~60 mg~~/kg/day		**Max: 60mg/kg/day
	**Not recommended under age 10		**Not recommended under age 10

Neil.m.young: Text replacement - "5 mg" to "5mg"

2016-07-21T12:24:32Z

Text replacement - "5 mg" to "5mg"

← Older revision		Revision as of 12:24, 21 July 2016
Line 7:		Line 7:
	==Adult Dosing==		==Adult Dosing==
	*Complex partial seizures: 30-60 mg/kg/day PO (divided bid-tid)		*Complex partial seizures: 30-60 mg/kg/day PO (divided bid-tid)
	**Start: 10-~~15 mg~~/kg/day PO divided qd-tid		**Start: 10-15mg/kg/day PO divided qd-tid
	**Increase by 5-10 mg/kg/day q7 days		**Increase by 5-10 mg/kg/day q7 days
	**Max: 60 mg/kg/day		**Max: 60 mg/kg/day
Line 19:		Line 19:

	*Absence seizures, simple and complex: 30-60 mg/kg/day PO (divided bid-tid)		*Absence seizures, simple and complex: 30-60 mg/kg/day PO (divided bid-tid)
	**Start: ~~15 mg~~/kg/day PO divided qd-tid, increase by 5-10 mg/kg/day every 7 days		**Start: 15mg/kg/day PO divided qd-tid, increase by 5-10 mg/kg/day every 7 days
	**Max: 60 mg/kg/day		**Max: 60 mg/kg/day

Line 36:		Line 36:
	==Pediatric Dosing==		==Pediatric Dosing==
	*Partial seizures, complex: 30-60 mg/kg/day PO divided bid-tid		*Partial seizures, complex: 30-60 mg/kg/day PO divided bid-tid
	**Start: 10-~~15 mg~~/kg/day PO divided qd-tid,		**Start: 10-15mg/kg/day PO divided qd-tid,
	**Increase by 5-10 mg/kg/day q7 days; Max: 60 mg/kg/day;		**Increase by 5-10 mg/kg/day q7 days; Max: 60 mg/kg/day;
	**Adjust dose based on treatment response and serum levels		**Adjust dose based on treatment response and serum levels
Line 42:		Line 42:

	*Absence seizures, simple and complex: 30-60 mg/kg/day PO divided bid-tid		*Absence seizures, simple and complex: 30-60 mg/kg/day PO divided bid-tid
	**Start: ~~15 mg~~/kg/day PO divided qd-tid		**Start: 15mg/kg/day PO divided qd-tid
	**Increase by 5-10 mg/kg/day q7 days		**Increase by 5-10 mg/kg/day q7 days
	**Max: 60 mg/kg/day		**Max: 60 mg/kg/day