Verapamil - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:57:53Z

Switch SMW query from broadtable to table format for better layout with TOC

← Older revision		Revision as of 21:57, 20 March 2026
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	\|?Has Route=Route		\|?Has Route=Route
	\|?Has Population=Population		\|?Has Population=Population
	\|format=~~broadtable~~		\|format=table
	\|headers=plain		\|headers=plain
	\|mainlabel=-		\|mainlabel=-

Danbot: Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

2026-03-20T17:25:41Z

Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

← Older revision		Revision as of 17:25, 20 March 2026
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	\|format=broadtable		\|format=broadtable
	\|headers=plain		\|headers=plain
	\|~~link~~=~~subject~~		\|mainlabel=-
	\|sort=Has Indication		\|sort=Has Indication
	\|limit=50		\|limit=50

Danbot: Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

2026-03-20T16:43:50Z

Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

@@ Line 48: / Line 48: @@
 *Reduces systemic vascular resistance, vasodiolates peripheral arteries
 ==Comments==
 ==See Also==

ClaireLewis at 23:27, 23 September 2019

2019-09-23T23:27:38Z

← Older revision		Revision as of 23:27, 23 September 2019
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	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: ~~Verapapmil~~ crosses the placenta and can cause adverse fetal effects such as heart block, hypotension, and bradycardia		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: Category C, verapapmil crosses the placenta and can cause adverse fetal effects such as heart block, hypotension, and bradycardia
	*[[Lactation risk categories\|Lactation risk]]: Present in breast milk with relative infant dose of <1% which is considered safe for the infant.		*[[Lactation risk categories\|Lactation risk]]: Present in breast milk with relative infant dose of <1% which is considered safe for the infant.
	*Renal dosing: Can accumulate causing increased effects, monitor closely and consider lowering dose.		*Renal dosing: Can accumulate causing increased effects, monitor closely and consider lowering dose.
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	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:Cardiology]]

Bmurray990: /* Special Populations */

2019-01-26T20:24:20Z

Special Populations

← Older revision		Revision as of 20:24, 26 January 2019
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	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]:		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: Verapapmil crosses the placenta and can cause adverse fetal effects such as heart block, hypotension, and bradycardia
	*[[Lactation risk categories\|Lactation risk]]:		*[[Lactation risk categories\|Lactation risk]]: Present in breast milk with relative infant dose of <1% which is considered safe for the infant.
	*Renal dosing: ~~no adjustment~~		*Renal dosing: Can accumulate causing increased effects, monitor closely and consider lowering dose.
	*Hepatic dosing: 20-50% of normal dose		*Hepatic dosing: 20-50% of normal dose

ClaireLewis: /* Pharmacology */

2016-09-10T23:07:09Z

Pharmacology

← Older revision		Revision as of 23:07, 10 September 2016
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	==Pharmacology==		==Pharmacology==
	*Half-life: 4-20 hours		*Half-life: 4-20 hours
	*Metabolism: Hepatic- P450 CYP3A4, CYP1A2, CYP2C8, CYP2C9 and CYP2C18		*Metabolism: Hepatic- [[P450]] CYP3A4, CYP1A2, CYP2C8, CYP2C9 and CYP2C18
	*Excretion: Renal primarily. Not dialyzable		*Excretion: Renal primarily. Not dialyzable

Rossdonaldson1: /* Contraindications */

2016-09-09T06:52:40Z

Contraindications

← Older revision		Revision as of 06:52, 9 September 2016
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	==Contraindications==		==Contraindications==
	*Allergy to class/drug		*Allergy to class/drug
	*Afib/flutter associated with accessory bypass tract, e.g. [[WPW]], [Lown-Ganong-Levine syndrome]]		*Afib/flutter associated with accessory bypass tract, e.g. [[WPW]], [[Lown-Ganong-Levine syndrome]]
	*[[Cardiogenic shock]], [[hypotension]], EF <30%		*[[Cardiogenic shock]], [[hypotension]], EF <30%
	*2nd or 3rd degree [[AV block]], [[sick sinus syndrome]]		*2nd or 3rd degree [[AV block]], [[sick sinus syndrome]]

Rossdonaldson1: /* Contraindications */

2016-09-09T06:52:26Z

Contraindications

← Older revision		Revision as of 06:52, 9 September 2016
Line 23:		Line 23:
	==Contraindications==		==Contraindications==
	*Allergy to class/drug		*Allergy to class/drug
	*Afib/flutter associated with accessory bypass tract, e.g. [[WPW]], [~~[long~~-~~ganong~~-~~levine~~]]		*Afib/flutter associated with accessory bypass tract, e.g. [[WPW]], [Lown-Ganong-Levine syndrome]]
	*[[Cardiogenic shock]], [[hypotension]], EF <30%		*[[Cardiogenic shock]], [[hypotension]], EF <30%
	*2nd or 3rd degree [[AV block]], [[sick sinus syndrome]]		*2nd or 3rd degree [[AV block]], [[sick sinus syndrome]]

	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===

Rossdonaldson1 at 06:46, 9 September 2016

2016-09-09T06:46:50Z

← Older revision		Revision as of 06:46, 9 September 2016
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	==Adult Dosing==		==Adult Dosing==
	*Atrial fibrillation, paroxysmal SVT		*[[Atrial fibrillation]], paroxysmal [[SVT]]
	**IV: 5-10mg (0.075-0.15 mg/kg), may give an initial 10mg IV after 30 minutes if inadequate response		**IV: 5-10mg (0.075-0.15 mg/kg), may give an initial 10mg IV after 30 minutes if inadequate response
	**PO: 240-48 mg daily in 3-4 divided doses		**PO: 240-48 mg daily in 3-4 divided doses
	*Angina, hypertension: 80-120mg PO 3 times per day		*Angina, hypertension: 80-120mg PO 3 times per day
	==Pediatric Dosing==		==Pediatric Dosing==
	*Afib/flutter, SVT		*[[Afib]]/[[flutter]], [[SVT]]
	**IV 0.1-0.2 (<1yo) or 0.1-0.3 (>1yo) mg/kg. Repeat after 30 minutes if inadequate response		**IV 0.1-0.2 (<1yo) or 0.1-0.3 (>1yo) mg/kg. Repeat after 30 minutes if inadequate response
	**PO: 4-10 mg/kg/day in 3 divided doses		**PO: 4-10 mg/kg/day in 3 divided doses
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	==Contraindications==		==Contraindications==
	*Allergy to class/drug		*Allergy to class/drug
	*Afib/flutter associated with accessory bypass tract, e.g. WPW, long-ganong-levine		*Afib/flutter associated with accessory bypass tract, e.g. [[WPW]], [[long-ganong-levine]]
	*Cardiogenic shock, hypotension, EF <30%		*[[Cardiogenic shock]], [[hypotension]], EF <30%
	*2nd or 3rd degree AV block, sick sinus syndrome		*2nd or 3rd degree [[AV block]], [[sick sinus syndrome]]
	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
	*AV block		*[[AV block]]
	*MI		*[[MI]]
	*Pulmonary edema		*[[Pulmonary edema]]
	===Common===		===Common===
	*Hypotension		*[[Hypotension]]
	*Edema		*Edema
	*URI or flu-like symptoms		*[[URI]] or [[flu-like symptoms]]
	*Dizziness, headache		*[[Dizziness]], [[headache]]
	*Constipation		*[[Constipation]]

	==Pharmacology==		==Pharmacology==

ClaireLewis: Created page with "==Administration== Type: Calcium channel blocker Dosage Forms: Routes of Administration: IV, PO Common Trade Names: ==Adult Dosing== *Atrial fibrillation, paroxysmal..."

2016-09-08T13:56:47Z

Created page with "==Administration== *Type: Calcium channel blocker *Dosage Forms: *Routes of Administration: IV, PO *Common Trade Names: ==Adult Dosing== *Atrial fibrillation, paroxysmal..."

New page

==Administration==
*Type: [[Calcium channel blocker]]
*Dosage Forms:
*Routes of Administration: IV, PO
*Common Trade Names:

==Adult Dosing==
*Atrial fibrillation, paroxysmal SVT
**IV: 5-10mg (0.075-0.15 mg/kg), may give an initial 10mg IV after 30 minutes if inadequate response
**PO: 240-48 mg daily in 3-4 divided doses
*Angina, hypertension: 80-120mg PO 3 times per day
==Pediatric Dosing==
*Afib/flutter, SVT
**IV 0.1-0.2 (<1yo) or 0.1-0.3 (>1yo) mg/kg. Repeat after 30 minutes if inadequate response
**PO: 4-10 mg/kg/day in 3 divided doses

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
*[[Lactation risk categories|Lactation risk]]:
*Renal dosing: no adjustment
*Hepatic dosing: 20-50% of normal dose

==Contraindications==
*Allergy to class/drug
*Afib/flutter associated with accessory bypass tract, e.g. WPW, long-ganong-levine
*Cardiogenic shock, hypotension, EF <30%
*2nd or 3rd degree AV block, sick sinus syndrome
==Adverse Reactions==
===Serious===
*AV block
*MI
*Pulmonary edema
===Common===
*Hypotension
*Edema
*URI or flu-like symptoms
*Dizziness, headache
*Constipation

==Pharmacology==
*Half-life: 4-20 hours
*Metabolism: Hepatic- P450 CYP3A4, CYP1A2, CYP2C8, CYP2C9 and CYP2C18
*Excretion: Renal primarily. Not dialyzable

==Mechanism of Action==
*Inhibits L-type (slow) calcium channels, blocking influx of calcium into myocardial cells
*Reduces systemic vascular resistance, vasodiolates peripheral arteries
==Comments==

==See Also==
*[[Calcium channel blockers]]
==References==
<references/>
[[Category:Pharmacology]]

Verapamil - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

Danbot: Fix SMW query: replace link=subject with mainlabel=- to fix broken subobject fragment links

Danbot: Add dynamic SMW Indications by Condition table (auto-populated from disease pages via MedicationDose template)

ClaireLewis at 23:27, 23 September 2019

Bmurray990: /* Special Populations */

ClaireLewis: /* Pharmacology */

Rossdonaldson1: /* Contraindications */

Rossdonaldson1: /* Contraindications */

Rossdonaldson1 at 06:46, 9 September 2016

ClaireLewis: Created page with "==Administration== *Type: Calcium channel blocker *Dosage Forms: *Routes of Administration: IV, PO *Common Trade Names: ==Adult Dosing== *Atrial fibrillation, paroxysmal..."

ClaireLewis: Created page with "==Administration== Type: Calcium channel blocker Dosage Forms: Routes of Administration: IV, PO Common Trade Names: ==Adult Dosing== *Atrial fibrillation, paroxysmal..."