ClaireLewis: /* References */

2019-09-23T23:30:36Z

References

← Older revision		Revision as of 23:30, 23 September 2019
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	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:Psychiatry]]

ClaireLewis: /* Common */

2019-01-26T22:17:19Z

Common

← Older revision		Revision as of 22:17, 26 January 2019
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	===Common===		===Common===
	*[[Dizziness[[, [[headache]], visual disturbance		*[[Dizziness]], [[headache]], visual disturbance
	*Somnolence, fatigue		*Somnolence, fatigue
	*[[Nausea]], [[diarrhea]]		*[[Nausea]], [[diarrhea]]

ClaireLewis: Created page with "==Administration== Type: Sedative/Hypnotic (benzodiazepine-like "Z-drug") Dosage Forms: Routes of Administration: PO, sublingual Common Trade Names: Ambien, Inter..."

2019-01-26T22:17:05Z

Created page with "==Administration== *Type: Sedative/Hypnotic (benzodiazepine-like "Z-drug") *Dosage Forms: *Routes of Administration: PO, sublingual *Common Trade Names: Ambien, Inter..."

New page

==Administration==
*Type: [[Sedative/Hypnotic]] ([[benzodiazepine]]-like "Z-drug")
*Dosage Forms:
*Routes of Administration: PO, sublingual
*Common Trade Names: Ambien, Intermezzo

==Adult Dosing==
*Immediate release: 5-10mg PO immediately prior to bedtime, 7-8h prior to planned awakening
*Extended release: 6.25-12.5mg PO immediately prior to bedtime, 7-8h prior to planned awakening
*Intermezzo (for insomnia in middle of night): 1.75-3.5mg SL once per night

==Pediatric Dosing==
''Safety/efficacy not established''

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*Pregnancy category C (fetal risk cannot be ruled out)

===Lactation risk===
*Infant risk cannot be ruled out

===Renal Dosing===
*Adult: No adjustment

===Hepatic Dosing===
*Adult:
**Mild-moderate impairment: max 5mg PO nightly
**Severe impairment: avoid use (may precipitate hepatic encephalopathy)

==Contraindications==
*Allergy to class/drug
*Caution with:
**Elderly patients (minimal improvement in sleep latency, increased risk of adverse effects)
**Concomitant use of CNS depressants (e.g. ETOH, other sedatives, opioids
**Sleep apnea, myasthenia gravis (risk of respiratory depression)

==Adverse Reactions==
===Serious===
*[[Tachycardia]], [[chest pain]]
*[[Hepatic encephalopathy]]
*[[Anaphylaxis]], [[angioedema]] (rare)
*Complex behavioral mannerisms (e.g. driving, making food, having sex while asleep with no recollection after the fact)
*Worsening depression, suicidality

===Common===
*[[Dizziness[[, [[headache]], visual disturbance
*Somnolence, fatigue
*[[Nausea]], [[diarrhea]]

==Pharmacology==
*Half-life: 2-3 hours (up to 9.9h in cirrhotics)
*Metabolism: Liver
*Excretion: <1% renal

==Mechanism of Action==
*Positive GABA-A receptor modulator, inhibits neuronal excitation

==Comments==

==See Also==
*[[Insomnia]]
*[[Benzodiazepine toxicity]]

==References==
<references/>
*Micromedex

[[Category:Pharmacology]]

Zolpidem - Revision history

ClaireLewis: /* References */

ClaireLewis: /* Common */

ClaireLewis: Created page with "==Administration== *Type: Sedative/Hypnotic (benzodiazepine-like "Z-drug") *Dosage Forms: *Routes of Administration: PO, sublingual *Common Trade Names: Ambien, Inter..."

ClaireLewis: Created page with "==Administration== Type: Sedative/Hypnotic (benzodiazepine-like "Z-drug") Dosage Forms: Routes of Administration: PO, sublingual Common Trade Names: Ambien, Inter..."