Antidotes: Difference between revisions

(Text replacement - " ==" to "==")
No edit summary
Line 42: Line 42:
| [[Cyanide]]  
| [[Cyanide]]  
|  
|  
Hydroxycobalamin
[[Hydroxycobalamin]]
OR
OR
Cyanide Antidote Kit (Amyl Nitrite, Sodium Nitrite, and Sodium Thiosulfate)
[[Cyanide antidote kit]] (Amyl Nitrite, Sodium Nitrite, and Sodium Thiosulfate)


|-
|-
Line 52: Line 52:
| [[Ethylene Glycol Poisoning|Ethylene glycol]]
| [[Ethylene Glycol Poisoning|Ethylene glycol]]
|  
|  
Fomepizole  
[[Fomepizole]]
*15mg/kg IV; then 10mg/kg q12h  
*15mg/kg IV; then 10mg/kg q12h  
|-
|-
| Fluoride  
| Fluoride  
| Calcium Gluconate
| [[Calcium gluconate]]
|-
|-
| [[Heparin (Unfractionated)|Heparin]]  
| [[Heparin (Unfractionated)|Heparin]]  
|  
|  
Protamine Sulfate
[[Protamine Sulfate]]
*Adult: 25-50mg IV (empiric dose) over 10 minutes
*Adult: 25-50mg IV (empiric dose) over 10 minutes
*Peds: 0.6mg/kg IV (empiric dose)  
*Peds: 0.6mg/kg IV (empiric dose)  
Line 67: Line 67:
|-
|-
| [[Iron (Fe)|Iron]]  
| [[Iron (Fe)|Iron]]  
| Deferoxamine
| [[Deferoxamine]]
|-
|-
| [[Isoniazid]] (INH)  
| [[Isoniazid]] (INH)  
Line 77: Line 77:
|-
|-
| [[Lead toxicity|Lead]]
| [[Lead toxicity|Lead]]
| EDTA, succimer
| [[EDTA]], [[succimer]]
|-
|-
| [[Mercury Poisoning|Mercury]]
| [[Mercury Poisoning|Mercury]]
| Dimercaprol (BAL)
| [[Dimercaprol]] (BAL)
|-
|-
| [[Methanol Toxicity|Methanol]]
| [[Methanol Toxicity|Methanol]]
Line 88: Line 88:
|-
|-
| [[Methemoglobinemia]]  
| [[Methemoglobinemia]]  
| Methylene blue  
| [[Methylene blue]]
|-
|-
| [[Opioid Overdose|Opiods]]   
| [[Opioid Overdose|Opiods]]   
Line 109: Line 109:
|-
|-
| [[Valproic acid toxicity|Valproate]]
| [[Valproic acid toxicity|Valproate]]
| L-Carnitine  
| [[L-Carnitine]]
|-
|-
| [[Warfarin (Coumadin) Reversal|Warfarin]]   
| [[Warfarin (Coumadin) Reversal|Warfarin]]   

Revision as of 17:20, 19 October 2016

TOXIN ANTIDOTE
Acetaminophen

N-Acetylcysteine

  • 150mg/kg IV load over 60min; followed by 50mg/kg IV over 4hr and then 100mg/kg IV over 16hr 
Anticholinergics Physostigmine
Arsenic Dimercaprol (BAL)
Benzodiazepines

Flumazenil

  • Adult: 0.2mg IV
  • Peds: 0.01mg/kg IV
Beta blockers

Glucagon

  • Adult: 3-10mg IV
  • Peds: 50-150mcg/kg IV
Ca channel blockers

Calcium chloride 10%

  • Adult: 10 mL IV
  • Peds: 0.2-0.25 mL/kg IV

High Dose Insulin (1 unit/kg/hr)

Clonidine

Naloxone

  • Adult: 0.4-2mg IV
  • Peds: 0.1mg/kg IV (max 2mg)
Cyanide

Hydroxycobalamin OR Cyanide antidote kit (Amyl Nitrite, Sodium Nitrite, and Sodium Thiosulfate)

Digoxin Dig Immune Fab
Ethylene glycol

Fomepizole

  • 15mg/kg IV; then 10mg/kg q12h
Fluoride Calcium gluconate
Heparin

Protamine Sulfate

  • Adult: 25-50mg IV (empiric dose) over 10 minutes
  • Peds: 0.6mg/kg IV (empiric dose)

Note: Rapid protamine infusion causes hypotension[1]

Iron Deferoxamine
Isoniazid (INH)

Pyridoxine (Vit B6)

  • Adult: 5gm IV
  • Peds: 1gm/kg regardless of age [2]
Lead EDTA, succimer
Mercury Dimercaprol (BAL)
Methanol

Fomepizole

  • 15mi/kg IV; then 10mg/kg q12h
Methemoglobinemia Methylene blue
Opiods Naloxone
Organophosphates Atropine + Pralidoxime
Sulfonylurea

Octreotide

  • Adult: 50–100mcg SC q6hr
  • Peds: 1mcg/kg SC q6hr
Tricyclic (TCA) Toxicity

Bicarbonate

  • 1-2mEq/kg IV bolus followed by 2mEq/kg/hr IV infusion
Valproate L-Carnitine
Warfarin Vitamin K, FFP, Prothrombin complex concentrate

References

<references>

  1. Hirsh J. et al. "Parenteral anticoagulants: ACCP Evidence-Based Clinical Practice Guidelines. Chest 2008; 133
  2. Minns, A. et al. Isoniazid-Induced Status Epilepticus in a Pediatric Patient After Inadequate Pyridoxine Therapy. Pediatric Emergency Care. 2010:26(5)380-381