Furosemide: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
''40mg [[furosemide]] = 20mg [[torsemide]] = 1mg [[bumetanide]]'' | |||
*[[Fluid overload]]: Typically 40 mg IV or normal PO dosage IV | *[[Fluid overload]]: Typically 40 mg IV or normal PO dosage IV | ||
*[[hypertension]]: 10-40mg PO QDAY-BID, max 600mg/day | *[[hypertension]]: 10-40mg PO QDAY-BID, max 600mg/day | ||
Revision as of 16:33, 22 December 2016
General
- Type: Diuretic
- Dosage Forms:20, 40, 80
- Common Trade Names: Lasix
- Approximately 50% bioavailability, so converting from oral to IV dose doubles oral dose[1]
- Furosemide absorption may be reduced in decompensated CHF[2]
Adult Dosing
40mg furosemide = 20mg torsemide = 1mg bumetanide
- Fluid overload: Typically 40 mg IV or normal PO dosage IV
- hypertension: 10-40mg PO QDAY-BID, max 600mg/day
- Hypercalcemia: 120mg/day PO divided QDAY - TID
Pediatric Dosing
- Hypercalcemia: 25-50mg IV q4h
Special Populations
- Pregnancy Rating:C
- Lactation: safety unknown
- Renal Dosing
- Adult: no adjustment, contraindicated in anuria
- Pediatric: no adjustment, contraindicated in anuria
- Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- anuria
- electrolyte imbalances
Adverse Reactions
Serious
- hypokalemia
- metabolic alkalosis
- hypovolemia
- ototoxicity
- hemolytic anemia
- vasculitis
- steven-johnson syndrome
- pancreatitis
- eosinophilia
Common
- urinary frequency
- dizziness
- nausea/vomiting
- weakness
- muscle cramping
- hypokalemia
- hypomagnesemia
- blurred vision
- diarrhea
- hyperglycemia
- hyperuricemia
- tinnitus
Pharmacology
- Half-life: 30-60 min
- Metabolism: liver minimally
- Excretion: urine
- Mechanism of Action: inhibits loop of henle and proximal and distal convoluted tubule sodium and chloride resorption