Tamsulosin: Difference between revisions
| Line 6: | Line 6: | ||
==Adult Dosing== | ==Adult Dosing== | ||
*0.4mg PO once daily | *0.4mg PO once daily or nightly | ||
===[[Urolithiasis]]=== | |||
*0.4mg PO QHS until stone expulsion | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
''Safety/efficacy not established'' | ''Safety/efficacy not established'' | ||
Revision as of 15:35, 28 April 2017
Administration
- Type: Alpha blocker
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names: Flomax
Adult Dosing
- 0.4mg PO once daily or nightly
Urolithiasis
- 0.4mg PO QHS until stone expulsion
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: B
- Lactation risk: Infant risk cannot be ruled out
Renal Dosing
- Adult: No adjustment for CrCl >10
Hepatic Dosing
- Adult: No adjustment
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Retinal detachment
- Priapism
Common
- Headache, dizziness, insomnia, somnolence
- Abnormal ejaculation
- Rhinitis
- Back pain
Pharmacology
- Half-life: 9-15h
- Metabolism: CYP3A4 and CYP2D6
- Excretion: Mostly renal
Mechanism of Action
- Alpha-1A antagonist→ smooth muscle relaxation in bladder neck, prostate, urethra→ increased urine flow rate