Flunitrazepam toxicity: Difference between revisions
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==Background== | ==Background== | ||
*Also known as Rohypnol | |||
*Used in Europe and Asia for Insomnia and Pre-op sedation | *Used in Europe and Asia for Insomnia and Pre-op sedation | ||
*Used in US as "date-rape" agent | *Used in US as "date-rape" agent | ||
*An intermediate acting [[benzodiazepine]] | |||
*Has strong affinity for benzodiazepine receptor | *Has strong affinity for benzodiazepine receptor | ||
==Clinical== | ==Clinical Features== | ||
*CNS depression within 30 minutes | *CNS depression within 30 minutes | ||
*Patients can usually be aroused with noxious stimuli | *Patients can usually be aroused with noxious stimuli | ||
*Half life 16-35 hours but coma can last 48h | *Half life 16-35 hours but coma can last 48h | ||
==Differential Diagnosis== | |||
{{Sedatve/hypnotic toxicity types}} | |||
=== | ==Evaluation== | ||
==Management== | |||
==Disposition== | |||
==See Also== | |||
*[[Benzodiazepines]] | |||
*[[Sedative/hypnotic toxicity]] | |||
==External Links== | |||
==References== | |||
<references/> | |||
[[Category:Toxicology]] | |||
Latest revision as of 06:34, 13 July 2017
Background
- Also known as Rohypnol
- Used in Europe and Asia for Insomnia and Pre-op sedation
- Used in US as "date-rape" agent
- An intermediate acting benzodiazepine
- Has strong affinity for benzodiazepine receptor
Clinical Features
- CNS depression within 30 minutes
- Patients can usually be aroused with noxious stimuli
- Half life 16-35 hours but coma can last 48h
Differential Diagnosis
Sedative/hypnotic toxicity
- Absinthe
- Barbiturates
- Benzodiazepines
- Chloral hydrate
- Gamma hydroxybutyrate (GHB)
- Baclofen toxicity
- Opioids
- Toxic alcohols
- Xylazine toxicity