Sulfadiazine: Difference between revisions
ClaireLewis (talk | contribs) (Created page with "==Administration== *Type: Antibiotic *Dosage Forms: *Routes of Administration: Oral *Common Trade Names: ==Adult Dosing== *2-4g PO daily in 1-4 doses ==Pediatric Dosing...") |
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* >2mo: 75-150 mg/kg PO daily in 1-4 doses | *>2mo: 75-150 mg/kg PO daily in 1-4 doses | ||
==Special Populations== | ==Special Populations== | ||
Revision as of 05:40, 14 July 2017
Administration
- Type: Antibiotic
- Dosage Forms:
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
- 2-4g PO daily in 1-4 doses
Pediatric Dosing
- >2mo: 75-150 mg/kg PO daily in 1-4 doses
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk has been demonstrated
- Renal dosing: use with caution
- Hepatic dosing: use with caution
Contraindications
- Allergy to class/drug
- Infants <2mo (except to treat congenital toxoplasmosis)
- Pregnant women at term
- Breastfeeding
Adverse Reactions
Serious
- SJS/TEN
- Agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia, aplastic anemia,
- Crystalluria
Common
- Rash
- Nausea/vomiting, diarrhea, abdominal pain
Pharmacology
- Half-life: 7-16.8h
- Metabolism: Hepatic
- Excretion: Mostly renal
Mechanism of Action
- Inhibits bacterial synthesis of folic acid