Acute transfusion reaction: Difference between revisions

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==Acute==
==Acute==
 
# Intravascular Hemolytic TR
 
##ABO inconpatability --> serious
1) Intravascular Hemolytic TR
##Sx: fever/ch/joint or back pain/shock
 
##Tx: stop, fluids+lasix, re-check blood
-ABO inconpatability --> serious
# Febrile TR
 
##anitbodies --> mild
-Sx: fever/ch/joint or back pain/shock
##Sx: fever/ch/malaise
 
##Tx: R/O above
-Tx: stop, fluids+lasix, re-check blood
# Allergic
 
##Tx as allergic Rx --> range
2) Febrile TR
# Transfusion-Related Acute Lung Injury (TRALI)
 
##Sx: acute ARDS-like injury --> severe
-anitbodies --> mild
##Tx: stop trans, Tx as ARDS
 
# Sepsis (Bacterial Contamination)
-Sx: fever/ch/malaise
# Fluid Overload
 
-Tx: R/O above
 
3) Allergic
 
-Tx as allergic Rx --> range
 
4) Transfusion-Related Acute Lung Injury (TRALI)
 
-Sx: acute ARDS-like injury --> severe
 
-Tx: stop trans, Tx as ARDS
 
5) Sepsis (Bacterial Contamination)
 
6) Fluid Overload
 


==Delayed==
==Delayed==
 
# Extravascular Hemolytic TR
 
##days-weeks after --> mild
1) Extravascular Hemolytic TR
##Sx: fever/anemia/jaundice
 
##Tx: none
-days-weeks after --> mild
# Graft-vs-Host
 
##in leukemia/lymphoma pt if given trans after chemo (use leuk-poor components)
-Sx: fever/anemia/jaundice
##Sx: fever/rash/n/v/inc LFTs/pancytopenia --> severe
 
##Tx: no effective Tx --> death
-Tx: none
# Hemosiderosis
 
2) Graft-vs-Host
 
-in leukemia/lymphoma pt if given trans after chemo (use leuk-poor components)
 
-Sx: fever/rash/n/v/inc LFTs/pancytopenia --> severe
 
-Tx: no effective Tx --> death
 
3) Hemosiderosis
 


==Source ==
==Source ==
2/18/06 DONALDSON (adapted from Rosen)
2/18/06 DONALDSON (adapted from Rosen)


[[Category:Heme/Onc]]
[[Category:Heme/Onc]]

Revision as of 13:28, 15 March 2011

Acute

  1. Intravascular Hemolytic TR
    1. ABO inconpatability --> serious
    2. Sx: fever/ch/joint or back pain/shock
    3. Tx: stop, fluids+lasix, re-check blood
  2. Febrile TR
    1. anitbodies --> mild
    2. Sx: fever/ch/malaise
    3. Tx: R/O above
  3. Allergic
    1. Tx as allergic Rx --> range
  4. Transfusion-Related Acute Lung Injury (TRALI)
    1. Sx: acute ARDS-like injury --> severe
    2. Tx: stop trans, Tx as ARDS
  5. Sepsis (Bacterial Contamination)
  6. Fluid Overload

Delayed

  1. Extravascular Hemolytic TR
    1. days-weeks after --> mild
    2. Sx: fever/anemia/jaundice
    3. Tx: none
  2. Graft-vs-Host
    1. in leukemia/lymphoma pt if given trans after chemo (use leuk-poor components)
    2. Sx: fever/rash/n/v/inc LFTs/pancytopenia --> severe
    3. Tx: no effective Tx --> death
  3. Hemosiderosis

Source

2/18/06 DONALDSON (adapted from Rosen)

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