Ceftriaxone: Difference between revisions
(Created page with "==General== *Type: *Dosage Forms: *Common Trade Names: ==Adult Dosing== ==Pediatric Dosing== ==Contraindications== *Allergy to class/drug ==Adverse Reactions== ==Pharma...") |
No edit summary |
||
| Line 1: | Line 1: | ||
==General== | ==General== | ||
*Type: | *Type: 3rd generation [[cephalosporins]] | ||
*Dosage Forms: | *Dosage Forms: IM, IV | ||
*Common Trade Names: | *Common Trade Names: Rocephin | ||
==Adult Dosing== | ==Adult Dosing== | ||
*1-2g IM/IV q24h | |||
**Max: 4g/24h | |||
===Bacterial [[Meningitis]]=== | |||
*4g IV divided q12-24h x 7-21 days | |||
===[[Gonococcal]]=== | |||
*Uncomplicated, initial: 250mg IM x 1 | |||
**Also treat for chlamydia regardless of test results | |||
*Uncomplicated, recurrent of persistent: 500-1000mg IM x 1 | |||
*Disseminated: 1g IM/IV q24h | |||
**May switch to cefixime PO after 24-48h if clinical improvement | |||
*Conjunctivitis: 1g IM x 1 | |||
*Prophylaxis (sexual assault victims) | |||
**250mg IM x 1 | |||
===[[PID]]=== | |||
*250mg IM x 1 | |||
*Use with doxycycline +/- metronidazole | |||
===[[Sinusitis]], Severe=== | |||
*1-2g IV q12-24h x 7-10 days | |||
===[[Endocarditis]]=== | |||
*1g IM/IV x 1 | |||
**30-60 min before procedure | |||
===[[Proctitis]]=== | |||
*250mg IM x 1 | |||
**Give with doxycycline | |||
===[[Epididymitis]]=== | |||
*250mg IM x 1 | |||
**Give with doxycycline | |||
===Surgical Prophylaxis=== | |||
*1g IV x 1 | |||
**Give 0.5-2h preop | |||
===Chancroid=== | |||
*250mg IM x 1 | |||
**Give with doxycycline | |||
===[[Typhoid Fever]]=== | |||
*60mg/kg IV q24h x 2wk | |||
**Max: 4g/24h | |||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
| Line 14: | Line 60: | ||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: 5.8-8.7h, 15h (CrCl 5-15) | ||
*Metabolism: | *Metabolism: CYP450 | ||
*Excretion: | *Excretion: Primarily urine | ||
*Mechanism of Action: | *Mechanism of Action: bactericidal; inhibits cell wall synthesis | ||
==Pregnancy/Lactation== | ==Pregnancy/Lactation== | ||
*Pregnancy: | *Pregnancy: B | ||
*Lactation: | *Lactation: Probably safe | ||
==See Also== | ==See Also== | ||
*[[Antibiotics (Main)]] | |||
==Source== | ==Source== | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
Revision as of 07:01, 7 February 2014
General
- Type: 3rd generation cephalosporins
- Dosage Forms: IM, IV
- Common Trade Names: Rocephin
Adult Dosing
- 1-2g IM/IV q24h
- Max: 4g/24h
Bacterial Meningitis
- 4g IV divided q12-24h x 7-21 days
Gonococcal
- Uncomplicated, initial: 250mg IM x 1
- Also treat for chlamydia regardless of test results
- Uncomplicated, recurrent of persistent: 500-1000mg IM x 1
- Disseminated: 1g IM/IV q24h
- May switch to cefixime PO after 24-48h if clinical improvement
- Conjunctivitis: 1g IM x 1
- Prophylaxis (sexual assault victims)
- 250mg IM x 1
PID
- 250mg IM x 1
- Use with doxycycline +/- metronidazole
Sinusitis, Severe
- 1-2g IV q12-24h x 7-10 days
Endocarditis
- 1g IM/IV x 1
- 30-60 min before procedure
Proctitis
- 250mg IM x 1
- Give with doxycycline
Epididymitis
- 250mg IM x 1
- Give with doxycycline
Surgical Prophylaxis
- 1g IV x 1
- Give 0.5-2h preop
Chancroid
- 250mg IM x 1
- Give with doxycycline
Typhoid Fever
- 60mg/kg IV q24h x 2wk
- Max: 4g/24h
Pediatric Dosing
Contraindications
- Allergy to class/drug
Adverse Reactions
Pharmacology
- Half-life: 5.8-8.7h, 15h (CrCl 5-15)
- Metabolism: CYP450
- Excretion: Primarily urine
- Mechanism of Action: bactericidal; inhibits cell wall synthesis
Pregnancy/Lactation
- Pregnancy: B
- Lactation: Probably safe