Cocaine: Difference between revisions

Latest revision as of 14:35, 16 March 2018

This page is for the drug cocaine; for clinical effects see cocaine toxicity

1-3 mg/kg, max dose of 200 mg
- Some literature suggests maximum dose of 100 mg
- Ideally use lowest effective dose

Micromedex

Authors:

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-*[[Cocaine Intoxication]]
+''This page is for the drug cocaine; for clinical effects see [[cocaine toxicity]]''
-*[[Cocaine Chest Pain]]
+==Administration==
-*[[Cocaine Withdrawal]]
+*Type: Local anesthetic
-*[[Levamisole toxicity]]
+*Dosage Forms: 4% solution; 10% solution
+*Routes of Administration: Topical
+*Common Trade Names: Cocaine
+==Adult Dosing==
+*1-3 mg/kg, max dose of 200 mg
+**Some literature suggests maximum dose of 100 mg
+**Ideally use lowest effective dose
+==Pediatric Dosing==
+*1 mg/kg
+**No clear safe dose established
+==Special Populations==
+*[[Drug pregnancy categories|Pregnancy Rating]]: Category C
+*Lactation risk: Infant risk has been demonstrated
+===Renal Dosing===
+*Adult: N/A
+*Pediatric: N/A
+===Hepatic Dosing===
+*Adult: N/A
+*Pediatric: N/A
+==Contraindications==
+*Allergy to class/drug
+==Adverse Reactions==
+*[[Cocaine-associated chest pain]]
+*Sympathomimetic qualities
+**Tachycardia
+**Fever
+**Agitation
+**Diaphoresis
+==Pharmacology==
+*Half-life: 50 to 75 minutes (5.5 hours benzoylecgonine metabolite)
+*Metabolism: Plasma cholinesterase; liver
+*Excretion: Renal
+==Mechanism of Action==
+*Blocks reuptake of serotonin, dopamine and norepinephrine
+*Anesthetic effects achieved through sodium channel blockade
+==Comments==
 ==See Also==
-*[[Sympathomimetic Toxicity]]
+*[[Cocaine toxicity]]
+==References==
+Micromedex
+<references/>
-[[Category:Tox]]
+[[Category:Pharmacology]]
-[[Category:Drugs]]