Antidotes: Difference between revisions
Ostermayer (talk | contribs) No edit summary |
Ostermayer (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
{| | {| class="wikitable" | ||
|- | |- | ||
| | | | ||
TOXIN | TOXIN | ||
| ANTIDOTE | | ANTIDOTE | ||
|- | |- | ||
| [[Acetaminophen (Tylenol)|Acetaminophen]] | | [[Acetaminophen (Tylenol)|Acetaminophen]] | ||
| | | | ||
N-acetylcysteine | N-acetylcysteine | ||
| Line 13: | Line 13: | ||
|- | |- | ||
| Antidepressants (TCA) | | Antidepressants (TCA) | ||
| | | | ||
Bicarbonate | Bicarbonate | ||
| Line 20: | Line 20: | ||
|- | |- | ||
| Arsenic | | Arsenic | ||
| Dimercaprol (BAL) | | Dimercaprol (BAL) | ||
|- | |- | ||
| Benzodiazepines | | Benzodiazepines | ||
| Line 32: | Line 32: | ||
|- | |- | ||
| [[Beta-Blocker Toxicity|Beta blockers]] | | [[Beta-Blocker Toxicity|Beta blockers]] | ||
| | | | ||
Glucagon | Glucagon | ||
| Line 63: | Line 63: | ||
|- | |- | ||
| [[Cyanide]] | | [[Cyanide]] | ||
| | | | ||
Kit- Hydroxycobalamin, Sodium nitrite, Sodium thiosulfate | Kit- Hydroxycobalamin, Sodium nitrite, Sodium thiosulfate | ||
|- | |- | ||
| [[Digoxin Toxicity|Digoxin]] | | [[Digoxin Toxicity|Digoxin]] | ||
| [[Dig Immune Fab]] | | [[Dig Immune Fab]] | ||
|- | |- | ||
| [[Ethylene Glycol Poisoning|Ethylene glycol]] | | [[Ethylene Glycol Poisoning|Ethylene glycol]] | ||
| | | | ||
Fomepizole | Fomepizole | ||
| Line 81: | Line 81: | ||
| Calcium Gluconate | | Calcium Gluconate | ||
|- | |- | ||
| [[Heparin (Unfractionated)|Heparin]] | | [[Heparin (Unfractionated)|Heparin]] | ||
| | | | ||
Protamine | Protamine | ||
Adult: 25-50mg IV (empiric dose) | Adult: 25-50mg IV (empiric dose) over 10 minutes | ||
Peds: 0.6mg/kg IV (empiric dose) | Peds: 0.6mg/kg IV (empiric dose) | ||
''rapid protamine infusion causes hypotension''<ref>Hirsh J. et al. "Parenteral anticoagulants: ACCP Evidence-Based Clinical Practice Guidelines. Chest 2008; 133</ref> | |||
|- | |- | ||
| [[Iron (Fe)|Iron]] | | [[Iron (Fe)|Iron]] | ||
| Deferoxamine | | Deferoxamine | ||
|- | |- | ||
| Isoniazid (INH) | | Isoniazid (INH) | ||
| | | | ||
Pyridoxine (Vit B6) | Pyridoxine (Vit B6) | ||
| Line 102: | Line 103: | ||
|- | |- | ||
| Lead | | Lead | ||
| EDTA, succimer | | EDTA, succimer | ||
|- | |- | ||
| Mercury | | Mercury | ||
| Dimercaprol (BAL) | | Dimercaprol (BAL) | ||
|- | |- | ||
| Methanol | | Methanol | ||
| Fomepizole | | Fomepizole | ||
15mi/kg IV; then 10mg/kg q12h<br> | |||
|- | |- | ||
| Methemoglobin | | Methemoglobin | ||
| Methylene blue | | Methylene blue | ||
|- | |- | ||
| [[Opiod Overdose|Opiods]] | | [[Opiod Overdose|Opiods]] | ||
| Nalaxone | | Nalaxone | ||
|- | |- | ||
| [[Organophosphates]] | | [[Organophosphates]] | ||
| Atropine+pralidoxime | | Atropine+pralidoxime | ||
|- | |- | ||
| Sulfonylurea | | Sulfonylurea | ||
| Line 129: | Line 131: | ||
|- | |- | ||
| Valproate | | Valproate | ||
| Carnitine | | Carnitine | ||
|- | |- | ||
| [[Warfarin (Coumadin) Reversal|Warfarin]] | | [[Warfarin (Coumadin) Reversal|Warfarin]] | ||
| Vit K, FFP | | Vit K, FFP | ||
|} | |} | ||
Revision as of 00:11, 10 April 2014
|
TOXIN |
ANTIDOTE |
| Acetaminophen |
N-acetylcysteine 150mg/kg IV load over 60min; followed by 50mg/kg IV over 4hr and then 100mg/kg IV over 16hr |
| Antidepressants (TCA) |
Bicarbonate 1-2mEq/kg IV bolus followed by 2mEq/kg/hr IV infusion |
| Arsenic | Dimercaprol (BAL) |
| Benzodiazepines |
Flumazenil Adult: 0.2mg IV Peds: 0.01mg/kg IV |
| Beta blockers |
Glucagon Adult: 3-10mg IV Peds: 50-150mcg/kg IV |
|
Calcium chloride 10% Adult: 10 mL IV Peds: 0.2-0.25 mL/kg IV | |
|
Clonidine |
Naloxone Adult: 0.4-2mg IV Peds: 0.1mg/kg IV (max 2mg) |
| Cyanide |
Kit- Hydroxycobalamin, Sodium nitrite, Sodium thiosulfate |
| Digoxin | Dig Immune Fab |
| Ethylene glycol |
Fomepizole 15mi/kg IV; then 10mg/kg q12h |
| Fluoride | Calcium Gluconate |
| Heparin |
Protamine Adult: 25-50mg IV (empiric dose) over 10 minutes Peds: 0.6mg/kg IV (empiric dose) rapid protamine infusion causes hypotension[1] |
| Iron | Deferoxamine |
| Isoniazid (INH) |
Pyridoxine (Vit B6) Adult: 5gm IV Peds: 1gm/kg regardless of age [2] |
| Lead | EDTA, succimer |
| Mercury | Dimercaprol (BAL) |
| Methanol | Fomepizole
15mi/kg IV; then 10mg/kg q12h |
| Methemoglobin | Methylene blue |
| Opiods | Nalaxone |
| Organophosphates | Atropine+pralidoxime |
| Sulfonylurea |
Octreotide Adult: 50–100mcg SC q6hr Peds: 1mcg/kg SC q6hr |
| Valproate | Carnitine |
| Warfarin | Vit K, FFP |
Source
<references>