Ampicillin/Sulbactam: Difference between revisions
| Line 29: | Line 29: | ||
*3000mg IM/IV q6 hours x 14 days | *3000mg IM/IV q6 hours x 14 days | ||
==Pediatric Dosing== | ==Pediatric Dosing (<40kg)== | ||
'''Unasyn (ampicillin/sulbactam) is formulated at a 2:1 ratio (3g vial = 2g ampicillin + 1g sulbactam)''' | |||
Note: Dosage recommendations are expressed as mg of the ampicillin component. | |||
===General<ref>Red Book, 2012</ref>=== | |||
*'''<40kg''' | |||
**Mild-moderate | |||
***100-200mg ampicillin/kg/day IM/IV divided q6 hours | |||
***Max: 1000mg ampicillin | |||
**Severe: | |||
***200mg ampicillin/kg/day divided q6 hours | |||
***Meningitis: 400mg ampicillin/kg/day | |||
***Max: 2000mg | |||
*'''>40kg''' | |||
**1.5-3g IM/IV q6 hours | |||
**Max: Unasyn 12 g/day | |||
===[[Endocarditis]]=== | |||
*'''<40kg''' | |||
**200mg ampicillin/kg/day IM/IV divided q4-6 hours +/- [[gentamicin]] x 4-6 weeks | |||
*'''>40kg''' | |||
**3g IM/IV q6 hours +/- [[gentamicin]] x 4-6 weeks | |||
===[[Meningitis]]<ref>Red Book, 2009</ref>=== | |||
*'''<40kg''' | |||
**200-400mg ampicillin/kg/day IV divided q6 hours | |||
===[[SSTI]]=== | |||
*'''<40kg''' | |||
**200mg ampicillin/kg/day IM/IV divided q6 hours | |||
==Special Populations== | ==Special Populations== | ||
Revision as of 23:56, 17 April 2014
General
- Type: Amino-Penicillins
- Dosage Forms:
- Common Trade Names: Unasyn
Adult Dosing
General
- 1500-3000mg IV/IM q6 hours
- Max: 12g/day
Bite (for Pasteurella multocida Coverage)
- 1500-3000mg IM/IV q6 hours
Orbital Cellulitis
- 3000mg IM/IV q6 hours
Diabetic Foot Osteomyelitis[1]
- 3000mg IM/IV q6 hours
PID
- 3000mg IM/IV q6 hours + doxycycline
Pneumonia
- Aspiration or CAP
- 1500-3000mg IM/IV q6 hours
- Hospital-acquired: 3000mg IM/IV q6 hours
UTI, Pyelonephritis
- 3000mg IM/IV q6 hours x 14 days
Pediatric Dosing (<40kg)
Unasyn (ampicillin/sulbactam) is formulated at a 2:1 ratio (3g vial = 2g ampicillin + 1g sulbactam) Note: Dosage recommendations are expressed as mg of the ampicillin component.
General[2]
- <40kg
- Mild-moderate
- 100-200mg ampicillin/kg/day IM/IV divided q6 hours
- Max: 1000mg ampicillin
- Severe:
- 200mg ampicillin/kg/day divided q6 hours
- Meningitis: 400mg ampicillin/kg/day
- Max: 2000mg
- Mild-moderate
- >40kg
- 1.5-3g IM/IV q6 hours
- Max: Unasyn 12 g/day
Endocarditis
- <40kg
- 200mg ampicillin/kg/day IM/IV divided q4-6 hours +/- gentamicin x 4-6 weeks
- >40kg
- 3g IM/IV q6 hours +/- gentamicin x 4-6 weeks
Meningitis[3]
- <40kg
- 200-400mg ampicillin/kg/day IV divided q6 hours
SSTI
- <40kg
- 200mg ampicillin/kg/day IM/IV divided q6 hours
Special Populations
- Pregnancy:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action: