Ampicillin/Sulbactam: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===General=== | ===General=== | ||
* | *1.5-3g IV/IM q6 hours | ||
*Max: 12g/day | *Max: 12g/day | ||
===[[Bite]] (for Pasteurella multocida Coverage)=== | ===[[Bite]] (for Pasteurella multocida Coverage)=== | ||
* | *1.5-3g IM/IV q6 hours | ||
===[[Orbital Cellulitis]]=== | ===[[Orbital Cellulitis]]=== | ||
* | *3g IM/IV q6 hours | ||
===[[Diabetic Foot]] Osteomyelitis<ref>Lipsky, 2004</ref>=== | ===[[Diabetic Foot]] Osteomyelitis<ref>Lipsky, 2004</ref>=== | ||
* | *3g IM/IV q6 hours | ||
===[[PID]]=== | ===[[PID]]=== | ||
* | *3g IM/IV q6 hours + [[doxycycline]] | ||
===[[Pneumonia]]=== | ===[[Pneumonia]]=== | ||
*Aspiration or CAP | *Aspiration or CAP | ||
** | **1.5-3g IM/IV q6 hours | ||
*Hospital-acquired: | *Hospital-acquired: 3g IM/IV q6 hours | ||
===[[UTI]], [[Pyelonephritis]]=== | ===[[UTI]], [[Pyelonephritis]]=== | ||
* | *3g IM/IV q6 hours x 14 days | ||
==Pediatric Dosing (<40kg)== | ==Pediatric Dosing (<40kg)== | ||
Revision as of 23:57, 17 April 2014
General
- Type: Amino-Penicillins
- Dosage Forms:
- Common Trade Names: Unasyn
Adult Dosing
General
- 1.5-3g IV/IM q6 hours
- Max: 12g/day
Bite (for Pasteurella multocida Coverage)
- 1.5-3g IM/IV q6 hours
Orbital Cellulitis
- 3g IM/IV q6 hours
Diabetic Foot Osteomyelitis[1]
- 3g IM/IV q6 hours
PID
- 3g IM/IV q6 hours + doxycycline
Pneumonia
- Aspiration or CAP
- 1.5-3g IM/IV q6 hours
- Hospital-acquired: 3g IM/IV q6 hours
UTI, Pyelonephritis
- 3g IM/IV q6 hours x 14 days
Pediatric Dosing (<40kg)
Unasyn (ampicillin/sulbactam) is formulated at a 2:1 ratio (3g vial = 2g ampicillin + 1g sulbactam)
General[2]
- Mild-moderate
- 100-200mg ampicillin/kg/day IM/IV divided q6 hours
- Max: 1000mg ampicillin
- Severe:
- 200mg ampicillin/kg/day divided q6 hours
- Meningitis: 400mg ampicillin/kg/day
- Max: 2000mg
- Mild-moderate
Endocarditis
- 200mg ampicillin/kg/day IM/IV divided q4-6 hours +/- gentamicin x 4-6 weeks
Meningitis[3]
- <40kg
- 200-400mg ampicillin/kg/day IV divided q6 hours
SSTI
- 200mg ampicillin/kg/day IM/IV divided q6 hours
Special Populations
- Pregnancy:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action: