Ampicillin/Sulbactam

General

• Type: Amino-Penicillins
• Dosage Forms:
• Common Trade Names: Unasyn

Adult Dosing

General

• 1.5-3g IV/IM q6 hours
• Max: 12g/day

Bite (for Pasteurella multocida Coverage)

• 1.5-3g IM/IV q6 hours

Orbital Cellulitis

• 3g IM/IV q6 hours

Diabetic Foot Osteomyelitis

• 3g IM/IV q6 hours

PID

• 3g IM/IV q6 hours + doxycycline

Pneumonia

• Aspiration or CAP
  • 1.5-3g IM/IV q6 hours
• Hospital-acquired: 3g IM/IV q6 hours

UTI, Pyelonephritis

• 3g IM/IV q6 hours x 14 days

Pediatric Dosing (<40kg)

Unasyn (ampicillin/sulbactam) is formulated at a 2:1 ratio (3g vial = 2g ampicillin + 1g sulbactam)

General

• Mild-moderate
  • 100-200mg ampicillin/kg/day IM/IV divided q6 hours
  • First Dose: 25-50mg ampicillin/kg IM/IV x 1 (37.5-75mg Unasyn/kg IM/IV x 1)
  • Max: 1000mg ampicillin (1500mg Unasyn)
• Severe
  • 200mg ampicillin/kg/day IM/IV divided q6 hours
  • First Dose: 50mg ampicillin/kg IM/IV x 1 (75mg Unasyn/kg IM/IV x 1)
  • Max: 2000mg ampicillin (3000mg Unasyn)

Meningitis

• 400mg ampicillin/kg/day IM/IV divided q6 hours
• First Dose: 100mg ampicillin/kg IM/IV x 1 (150mg Unasyn/kg IM/IV x 1)
• Max: 2000mg ampicillin (3000mg Unasyn)

Endocarditis

• 200mg ampicillin/kg/day IM/IV divided q4-6 hours +/- gentamicin x 4-6 weeks

SSTI

• 200mg ampicillin/kg/day IM/IV divided q6 hours

Special Populations

• Pregnancy: B
• Lactation: Use caution
• Renal Dosing
  • Adult
  • Pediatric
• Hepatic Dosing
  • Adult
  • Pediatric

Contraindications

• Allergy to class/drug

Pharmacology

• Half-life:
• Metabolism:
• Excretion:
• Mechanism of Action:

See Also

• Antibiotics (Main)