Intralipid: Difference between revisions
| Line 1: | Line 1: | ||
==General== | ==General== | ||
*Type: Lipid emulsion | *Type: Lipid emulsion therapy | ||
*Dosage Forms: 20% | *Dosage Forms: 10%, 20%, and 30% lipid emulsions | ||
**Note that 20% is used for lipid rescue therapy for systemic drug toxicity<ref>http://www.lipidrescue.org/</ref> | |||
*Routes of Administration: IV | *Routes of Administration: IV | ||
*Common Trade Names: Intralipid | *Common Trade Names: Intralipid, Lipid Rescue <ref>http://www.lipidrescue.org/</ref> | ||
==Adult Dosing== | ==Adult Dosing== | ||
Revision as of 18:45, 15 May 2019
General
- Type: Lipid emulsion therapy
- Dosage Forms: 10%, 20%, and 30% lipid emulsions
- Note that 20% is used for lipid rescue therapy for systemic drug toxicity[1]
- Routes of Administration: IV
- Common Trade Names: Intralipid, Lipid Rescue [2]
Adult Dosing
- 1.5 ml/kg bolus[3]
- Followed by 0.25 ml/kg/min for 20 min or until hemodynamic stability is achieved.[4]
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation risk:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Emergency department indications
- Local anesthetic systemic toxicity
- Refractory hemodynamic instability secondary to ingestion of cardiodepressive medications / toxins
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Asystole (case reported) [5]
- Fat embolism
- Hypersensitivity reactions
Common
- Pancreatitis[6]
- Hypertriglyceridemia[6]
- Interferes with some lab measurements
- Glucose and magnesium concentrations become inaccurate
- Creatinine and lipase become unmeasurable
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
- Emulsion acts as a “lipid sink,” surrounding a lipophilic drug molecule and rendering it ineffective
- Fatty acids from the ILE provide the myocardium with a ready energy source, improving cardiac function
Comments
See Also
- Beta-blocker toxicity
- Calcium channel blocker toxicity
- Local Anesthetic Systemic Toxicity (LAST)
- Tricyclic antidepressant toxicity
External Links
References
- ↑ http://www.lipidrescue.org/
- ↑ http://www.lipidrescue.org/
- ↑ Cave, G. Intravenous Lipid Emulsion as Antidote Beyond Local Anesthetic Toxicity: A Systematic Review. 2009. 16(9)815–824
- ↑ Dillane D, Finucane BT. Local anesthetic systemic toxicity. Can J Anaesth. 2010 Apr;57(4):368-80.
- ↑ Cole JB et al. Asystole immediately following intravenous fat emulsion for overdose. J Med Toxicol. 2014;10(3)307-310
- ↑ 6.0 6.1 Kostic MA and Gorelick M. Review of the use of lipid emulsion in nonlocal anesthetic poisoning. Pediatric Emergency Care 2014;30:427-436