Contrast-induced nephropathy: Difference between revisions
(Created page with "==Background== ==Clinical Features== ==Differential Diagnosis== ==Workup== ==Management== ==Disposition== ==See Also== *Contrast with Renal Dysfunction *Creatinine...") |
Silas Chiu (talk | contribs) (Added background clinical features) |
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==Background== | ==Background== | ||
* Vasoconstriction leading to ischemia in the deeper portion of the outer medulla | |||
* Toxic to kidney tubular cells, inducing vacuolization, change in mitochondrial function, and apoptosis | |||
==Clinical Features== | ==Clinical Features== | ||
* 0.5mg/dl absolute or >25% relative increase in serum creatinine 48-72hrs after contrast exposure | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
* Poor renal perfusion | |||
* Nephrotoxic medications | |||
==Workup== | ==Workup== | ||
*Same for AKI | |||
==Management== | ==Management== | ||
*Hydration | |||
*N-acetylcysteine | |||
==See Also== | ==See Also== | ||
*[[Contrast with Renal Dysfunction]] | *[[Contrast with Renal Dysfunction]] | ||
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==Sources== | ==Sources== | ||
*Golshahi, J, Hasri H, Gharipour M. Contrast-induced nephropathy; A literature review. J Nephropathol. 2014;3(2):51-56. | |||
*Persson PB, Hansell P, Liss P. Pathophysiology of contrast medium induced nephropathy. Kidney Int. 2005;68:14–22 | |||
Revision as of 21:24, 10 June 2014
Background
- Vasoconstriction leading to ischemia in the deeper portion of the outer medulla
- Toxic to kidney tubular cells, inducing vacuolization, change in mitochondrial function, and apoptosis
Clinical Features
- 0.5mg/dl absolute or >25% relative increase in serum creatinine 48-72hrs after contrast exposure
Differential Diagnosis
- Poor renal perfusion
- Nephrotoxic medications
Workup
- Same for AKI
Management
- Hydration
- N-acetylcysteine
See Also
Sources
- Golshahi, J, Hasri H, Gharipour M. Contrast-induced nephropathy; A literature review. J Nephropathol. 2014;3(2):51-56.
- Persson PB, Hansell P, Liss P. Pathophysiology of contrast medium induced nephropathy. Kidney Int. 2005;68:14–22