Pyrimethamine: Difference between revisions
ClaireLewis (talk | contribs) (Created page with "''Note: As of 2015, pyrimethamine is only available in the US through a special pharmacy program''<ref>https://aidsinfo.nih.gov/news/1604/notice-of-availability-of-pyrimethami...") |
ClaireLewis (talk | contribs) |
||
| (One intermediate revision by the same user not shown) | |||
| Line 1: | Line 1: | ||
''Note: As of 2015, pyrimethamine is only available in the US through a special pharmacy program''<ref>https://aidsinfo.nih.gov/news/1604/notice-of-availability-of-pyrimethamine</ref> | ''Note: As of 2015, pyrimethamine is only available in the US through a special pharmacy program''<ref>https://aidsinfo.nih.gov/news/1604/notice-of-availability-of-pyrimethamine</ref> | ||
==Administration== | ==Administration== | ||
*Type: Antiparasitic, indicated for treatment and prophylaxis of [[Toxoplasmosis]] and [[malaria]] | *Type: [[Antiparasitic]], indicated for treatment and prophylaxis of [[Toxoplasmosis]] and [[malaria]] | ||
*Dosage Forms: | *Dosage Forms: | ||
*Routes of Administration: Oral | *Routes of Administration: Oral | ||
*Common Trade Names: | *Common Trade Names: | ||
==Adult Dosing== | ==Adult Dosing== | ||
| Line 41: | Line 41: | ||
<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:ID]] | |||
Latest revision as of 22:11, 23 September 2019
Note: As of 2015, pyrimethamine is only available in the US through a special pharmacy program[1]
Administration
- Type: Antiparasitic, indicated for treatment and prophylaxis of Toxoplasmosis and malaria
- Dosage Forms:
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
- 25-200mg PO (weekly or daily, depending on indication), in combination with other antimicrobials
Pediatric Dosing
- 1-3mg/kg PO
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk minimal
- Renal dosing:
Contraindications
- Allergy to class/drug
- megaloblastic anemia due to folate deficiency
Adverse Reactions
Serious
- SJS, TEN
- Pancytopenia, leukopenia, thrombocytopenia, megaloblastic anemia
Common
- Rash
Pharmacology
- Half-life: 52-97 hours
- Metabolism: Hepatic
- Excretion:
Mechanism of Action
- Blocks protozoal dihydrofolate reductase, inhibiting nucleic acid synthesis