Sulfadiazine: Difference between revisions
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===Serious=== | ===Serious=== | ||
*SJS/TEN | *SJS/TEN | ||
*Agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia, aplastic anemia | *Agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia, aplastic anemia | ||
*Crystalluria | *Crystalluria | ||
*Allergic Myocarditis | |||
===Common=== | ===Common=== | ||
*Rash | *Rash | ||
*Nausea/vomiting, diarrhea, abdominal pain | *Nausea/vomiting, diarrhea, abdominal pain | ||
*Tinnitus | |||
*Headache, Depression, Insomnia | |||
==Pharmacology== | ==Pharmacology== | ||
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<references/> | <references/> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
[[Category:ID]] | |||
Latest revision as of 22:37, 23 September 2019
Administration
- Type: Antibiotic
- Dosage Forms: Tablet, 500mg
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
- 2-4g PO daily in 1-4 doses
Pediatric Dosing
- >2mo: 75-150 mg/kg PO daily in 1-4 doses
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk has been demonstrated
- Renal dosing: use with caution
- Hepatic dosing: use with caution
Contraindications
- Allergy to class/drug
- Infants <2mo (except to treat congenital toxoplasmosis)
- Pregnant women at term
- Breastfeeding
Adverse Reactions
Serious
- SJS/TEN
- Agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia, aplastic anemia
- Crystalluria
- Allergic Myocarditis
Common
- Rash
- Nausea/vomiting, diarrhea, abdominal pain
- Tinnitus
- Headache, Depression, Insomnia
Pharmacology
- Half-life: 7-16.8h
- Metabolism: Hepatic
- Excretion: Mostly renal
Mechanism of Action
- Inhibits bacterial synthesis of folic acid