Alpha blockers: Difference between revisions
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==Background== | ==Background== | ||
*Also known as α-blockers | *Also known as α-blockers | ||
** | **α<sub>1</sub>-blockers act on α<sub>1</sub>-adrenoceptors | ||
** | **α<sub>2</sub>-blockers act on α<sub>2</sub>-adrenoceptors | ||
*Act as neutral antagonists or inverse agonists of | *Act as neutral antagonists or inverse agonists of α-adrenergic receptors (α-adrenoceptors) | ||
==Medications== | ==Medications== | ||
===Non-selective=== | ===Non-selective=== | ||
* [[Phenoxybenzamine]] | *[[Phenoxybenzamine]] | ||
* [[Phentolamine]] | *[[Phentolamine]] | ||
* [[Tolazoline]] | *[[Tolazoline]] | ||
* [[Trazodone]] | *[[Trazodone]] | ||
* Typical and atypical [[antipsychotics]] | *Typical and atypical [[antipsychotics]] | ||
===Selective | ===Selective α<sub>1</sub>=== | ||
* [[Alfuzosin]] | *[[Alfuzosin]] | ||
* [[Doxazosin]] | *[[Doxazosin]] | ||
* [[Prazosin]] ([[inverse agonist]]) | *[[Prazosin]] ([[inverse agonist]]) | ||
* [[Tamsulosin]] | *[[Tamsulosin]] | ||
* [[Terazosin]] | *[[Terazosin]] | ||
* [[Silodosin]] | *[[Silodosin]] | ||
===Selective | ===Selective α<sub>2</sub>=== | ||
* [[Atipamezole]] | *[[Atipamezole]] | ||
* [[Idazoxan]] | *[[Idazoxan]] | ||
* [[Mirtazapine]] | *[[Mirtazapine]] | ||
* [[Yohimbine]] | *[[Yohimbine]] | ||
===Mixed=== | ===Mixed=== | ||
*The agents [[carvedilol]] and [[labetalol]] are both α- and [[ | *The agents [[carvedilol]] and [[labetalol]] are both α- and [[β-blocker|β-blockers]]. | ||
==Uses== | ==Uses== | ||
*[[hypertension]] | *[[hypertension]] | ||
*[[ | *[[Raynaud’s disease]] | ||
*[[scleroderma]] | *[[scleroderma]] | ||
*[[generalized anxiety disorder]] | *[[generalized anxiety disorder]] | ||
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==See also== | ==See also== | ||
*[[Antihypertensive medications]] | |||
*[[Beta blocker]] | *[[Beta blocker]] | ||
*[[Yohimbine toxicity]] | |||
==References== | ==References== | ||
<references/> | |||
[[Category: | [[Category:Pharmacology]] | ||
Latest revision as of 14:28, 19 October 2019
Background
- Also known as α-blockers
- α1-blockers act on α1-adrenoceptors
- α2-blockers act on α2-adrenoceptors
- Act as neutral antagonists or inverse agonists of α-adrenergic receptors (α-adrenoceptors)
Medications
Non-selective
- Phenoxybenzamine
- Phentolamine
- Tolazoline
- Trazodone
- Typical and atypical antipsychotics
Selective α1
Selective α2
Mixed
- The agents carvedilol and labetalol are both α- and β-blockers.
Uses
- hypertension
- Raynaud’s disease
- scleroderma
- generalized anxiety disorder
- panic disorder
- posttraumatic stress disorder
- benign prostatic hyperplasia