Paraquat toxicity: Difference between revisions
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==Background== | ==Background== | ||
Paraquat is an herbicide that has a rapid and large distribution and can be fatal even with small ingestions. | Paraquat is an herbicide that has a rapid and large distribution and can be fatal even with small ingestions. It has a high case-fatality rate (>50%)<ref>Gawaramanna I, Buckley N. Medical management of paraquat ingestion. Br J Clin Pharmacol. 2011;72(5):745–757</ref> which makes it a frequent means of suicide in the developing world, as well as a dangerous accidental occupational exposure. | ||
==Clinical Features== | ==Clinical Features== | ||
Revision as of 17:29, 17 July 2020
Background
Paraquat is an herbicide that has a rapid and large distribution and can be fatal even with small ingestions. It has a high case-fatality rate (>50%)[1] which makes it a frequent means of suicide in the developing world, as well as a dangerous accidental occupational exposure.
Clinical Features
- Gastrointestinal: predominate early
- Paraquat tongue
- Esophageal and gastric erosion
- Nausea and vomiting
- Pulmonary: occurs due to distribution to pneumocytes
- Pneumonitis
- Pulmonary fibrosis (delayed)
- Multiorgan failure
- Acute renal failure
- Hepatic necrosis
- Myocardial necrosis
- Internal bleeding
Differential Diagnosis
Evaluation
Management
Disposition
See Also
External Links
References
- ↑ Gawaramanna I, Buckley N. Medical management of paraquat ingestion. Br J Clin Pharmacol. 2011;72(5):745–757