Sympathomimetic toxicity: Difference between revisions
(Created page with "*Cocaine *Amphetamines *Ketamine ==Differential Diagnosis== {{Template:Toxidrome Chart}} ==See Also== *Toxidromes Category:Tox") |
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*[[Amphetamines]] | *[[Amphetamines]] | ||
*[[Ketamine]] | *[[Ketamine]] | ||
*[[Synthetic Cannabinoids]] | |||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
{{Template:Toxidrome Chart}} | {{Template:Toxidrome Chart}} | ||
==Treatment== | |||
*Sedation with a [[Benzodiazepine]] | |||
==Complications== | |||
*[[Rhabdomyolysis]] is common complication <ref name="tox">O'Connor AD, Padilla-Jones A, Gerkin AD, et al. Prevalence of Rhabdomyolysis in Sympathomimetic Toxicity: a Comparison of Stimulants. J Med Toxicol 2014</ref> | |||
*[[Bath Salts]] - 63% <ref name="tox"></ref> | |||
*[[Amphetamines]] - 40% | |||
*[[Cocaine]] - 33% | |||
==See Also== | ==See Also== | ||
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[[Category:Tox]] | [[Category:Tox]] | ||
==Sources== | |||
<references/> | |||
Revision as of 17:37, 4 December 2014
Differential Diagnosis
Toxidrome Chart
| Finding | Cholinergic | Anticholinergic | Sympathomimetic | Sympatholytic^ | Sedative/Hypnotic |
| Example | Organophosphates | TCAs | Cocaine | Clonidine | ETOH |
| Temp | Nl | Nl / ↑ | Nl / ↑ | Nl / ↓ | Nl / ↓ |
| RR | Variable | Nl / ↓ | Variable | Nl / ↓ | Nl / ↓ |
| HR | Variable | ↑ | ↑ (sig) | Nl / ↓ | Nl / ↓ |
| BP | ↑ | ↑ | ↑ | Nl / ↓ | Nl / ↓ |
| LOC | Nl / Lethargic | Nl, agitated, psychotic, comatose | Nl, agitated, psychotic | Nl, Lethargic, or Comatose | Nl, Lethargic, or Comatose |
| Pupils | Variable | Mydriatic | Mydriatic | Nl / Miotic | |
| Motor | Fasciculations, Flacid Paralysis | Nl | Nl / Agitated | Nl | |
| Skin | Sweating (sig) | Hot, dry | Sweating | Dry | |
| Lungs | Bronchospasm / rhinorrhea | Nl | Nl | Nl | |
| Bowel Sounds | Hyperactive (SLUDGE) | ↓ / Absent | Nl / ↓ | Nl / ↓ |
- ^Consider Sympatholytic when looking at Sedative OD or someone who doesn't respond to Narcan
- Withdrawal from substances have the opposite effect
Treatment
- Sedation with a Benzodiazepine
Complications
- Rhabdomyolysis is common complication [1]
- Bath Salts - 63% [1]
- Amphetamines - 40%
- Cocaine - 33%