Transverse myelitis

Background

• Inflammatory disorder that involves a complete transverse section of the spinal cord
  • Results from viral infection, postvaccination or as part of MS, SLE, or cancer
• May present exactly like a compressive lesion of the spinal cord
• Usually thoracic origin, rarely cervical spine

Clinical Features

• May progress over days-weeks
• Neck or back pain + neuro complaints:
  • Bilateral motor, sensory, and autonomic disturbances
  • Fecal/urinary retention and incontinence

Differential Diagnosis

Weakness

• Neuromuscular weakness
  • Upper motor neuron:
    • CVA
    • Hemorrhagic stroke
    • Multiple sclerosis
    • Amyotrophic Lateral Sclerosis (ALS) (upper and lower motor neuron)
  • Lower motor neuron:
    • Spinal and bulbar muscular atrophy (Kennedy's syndrome)
  • Spinal cord disease:
    • Infection (Epidural abscess)
    • Infarction/ischemia
    • Trauma (Spinal Cord Syndromes)
    • Inflammation (Transverse Myelitis)
      • Acute flaccid myelitis
    • Degenerative (Spinal muscular atrophy)
    • Tumor
  • Peripheral nerve disease:
    • Guillain-Barre syndrome
    • Toxins (Ciguatera)
    • Tick paralysis
    • Diabetic peripheral neuropathy
  • Neuromuscular junction disease:
    • Myasthenia gravis crisis
    • Botulism
    • Organophosphate toxicity
    • Lambert-Eaton myasthenic syndrome
  • Muscle disease:
    • Rhabdomyolysis
    • Dermatomyositis
    • Polymyositis
    • Alcoholic myopathy
• Non-neuromuscular weakness
  • Can't miss diagnoses:
    • ACS
    • Arrhythmia/Syncope
    • Severe infection/Sepsis
    • Hypoglycemia
    • Periodic paralysis (electrolyte disturbance, K, Mg, Ca)
      • Hypokalemic periodic paralysis
      • Thyrotoxic periodic paralysis
    • Respiratory failure
  • Emergent Diagnoses:
    • Symptomatic Anemia
    • Severe dehydration
    • Hypothyroidism
    • Polypharmacy
    • Malignancy
    • Aortic disease - occlusion, stenosis, dissection
  • Other causes of weakness and paralysis
    • Acute intermittent porphyria (ascending weakness)

Diagnosis

• Neurologic findings that are c/w epidural compression but normal MRI

Management

• Must rule-out compressive lesion of the cord
• MRI
  • May show cord swelling
• LP
  • Contains monocytes, protein content is slightly increased, and IgG index is elevated
• Foley for bladder decompression
• Consider work up for clotting disorder for spinal artery thrombosis, drug user, risk for aortic dissection
• Admit for corticosteroids and plasma exchange
• The more rapid the progression is, the worse the prognosis

Source

• Tintinalli
• Perron AD, Huff JS. “Spinal Cord Disorders,” in Rosen’s Emergency Medicine Concepts and Clinical Practice, edited by Marx JA, Hockberger RS, Walls RM, et al., 1389-1395. Philadelphia: Mosby, 2010.