Vitamin E deficiency: Difference between revisions
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==Background== | ==Background== | ||
*Most common causes: | *Most common causes: | ||
**Severe malabsorption ( | **Severe malabsorption (e.g. [[cystic fibrosis]], [[celiac sprue]], pancreatic insufficiency) | ||
**Abetalipoproteinemia (genetic disorder) | **Abetalipoproteinemia (genetic disorder) | ||
**Chronic cholestatic liver disease (e.g. biliary atresia) | **Chronic cholestatic liver disease (e.g. [[biliary atresia]]) | ||
==Clinical Features== | ==Clinical Features== | ||
*Areflexia | *Areflexia | ||
*Gait disturbance | *[[ataxia|Gait disturbance]] | ||
*Decreased vibration and proprioception | *Decreased vibration and proprioception | ||
*Ophthalmoplegia | *Ophthalmoplegia | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
{{template:vitamin deficiencies DDX}} | |||
==Evaluation== | ==Evaluation== | ||
Latest revision as of 19:14, 23 February 2021
Background
- Most common causes:
- Severe malabsorption (e.g. cystic fibrosis, celiac sprue, pancreatic insufficiency)
- Abetalipoproteinemia (genetic disorder)
- Chronic cholestatic liver disease (e.g. biliary atresia)
Clinical Features
- Areflexia
- Gait disturbance
- Decreased vibration and proprioception
- Ophthalmoplegia
Differential Diagnosis
Vitamin deficiencies
- Vitamin A deficiency
- Vitamin B deficiencies
- Vitamin B1 deficiency (Thiamine)
- Vitamin B3 deficiency (Pellagra)
- Vitamin B9 deficiency (Folate)
- Vitamin B7 deficiency (Biotin)
- Vitamin B12 deficiency
- Vitamin C deficiency (Scurvy)
- Vitamin D deficiency (Rickets)
- Vitamin E deficiency
- Vitamin K deficiency
- Zinc deficiency
Evaluation
- Plasma Vitamin E level <0.5 mg/dL
Management
- Vitamin E repletion