Meclizine: Difference between revisions
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==General== | ==General== | ||
*Type: Antihistamine, H1 antagonist | *Type: [[Antihistamine]], H1 antagonist | ||
*Dosage Forms: 12.5, 25, | *Dosage Forms: 12.5, 25, 32mg oral tablet; 25mg oral chewable tablet | ||
*Common Trade Names: Univert, Vertin-32, Dramamine less drowsy, Motion-Time | *Common Trade Names: Univert, Vertin-32, Dramamine less drowsy, Motion-Time | ||
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*25mg PO QID | *25mg PO QID | ||
===Motion | ===[[Motion sickness]]=== | ||
*25- | *25-100mg PO 1 hour before activity. May repeat q24h | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
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==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B | ||
*Lactation: | *Lactation: Excretion in breast milk unknown | ||
*Renal Dosing | *Renal Dosing: n/a | ||
*Hepatic Dosing: n/a | |||
*Hepatic Dosing | |||
==Contraindications== | ==Contraindications== | ||
| Line 30: | Line 26: | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*CNS depression | |||
*Caution in asthma, glaucoma, BPH, pyloric obstruction | |||
===Common=== | ===Common=== | ||
*Drowsiness, fatigue | |||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Onset: 1 hour | ||
*Metabolism: | *Half-life: 5 hours | ||
*Excretion: | *Metabolism: Hepatic | ||
*Mechanism of Action: | *Excretion: Urine and feces | ||
*Mechanism of Action: Central anticholinergic; blocks chemoreceptor trigger zone. Decreases middle ear excitability, blocks vestibular-cerebellar pathways | |||
==See Also== | ==See Also== | ||
*[[Antihistamines]] | |||
*[[Anticholinergic toxicity]] | |||
== | ==References== | ||
Lexicomp | |||
<references/> | <references/> | ||
[[Category: | [[Category:Pharmacology]] | ||
Latest revision as of 22:35, 7 March 2021
General
- Type: Antihistamine, H1 antagonist
- Dosage Forms: 12.5, 25, 32mg oral tablet; 25mg oral chewable tablet
- Common Trade Names: Univert, Vertin-32, Dramamine less drowsy, Motion-Time
Adult Dosing
Vertigo
- 25mg PO QID
Motion sickness
- 25-100mg PO 1 hour before activity. May repeat q24h
Pediatric Dosing
- >= 12 yrs old: Adult dosing
- < 12 yrs: No dosing specified in drug insert
Special Populations
- Pregnancy Rating: B
- Lactation: Excretion in breast milk unknown
- Renal Dosing: n/a
- Hepatic Dosing: n/a
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- CNS depression
- Caution in asthma, glaucoma, BPH, pyloric obstruction
Common
- Drowsiness, fatigue
Pharmacology
- Onset: 1 hour
- Half-life: 5 hours
- Metabolism: Hepatic
- Excretion: Urine and feces
- Mechanism of Action: Central anticholinergic; blocks chemoreceptor trigger zone. Decreases middle ear excitability, blocks vestibular-cerebellar pathways
See Also
References
Lexicomp