Neuromuscular blocking agents: Difference between revisions
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|[[Succinylcholine]] | |[[Succinylcholine]] | ||
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*[[hypotension]], transiently,<ref name=Rang151/> by release of histamine | *[[hypotension]], transiently,<ref name=Rang151/> by release of histamine | ||
*Toxic metabolite called [[laudanosine]], greater accumulation in individuals with renal failure | *Toxic metabolite called [[laudanosine]], greater accumulation in individuals with renal failure | ||
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|[[Vecuronium]] (Norcuron) | |[[Vecuronium]] (Norcuron) | ||
|60 | |60 | ||
|30–40 | |30–40 | ||
|Few, | |Few, may cause prolonged paralysis and promote muscarinic block | ||
|- | |- | ||
|[[Rocuronium]] (Zemuron) | |[[Rocuronium]] (Zemuron) | ||
|75 | |75 | ||
|45–70 | |45–70 | ||
|may promote muscarinic block | |may promote muscarinic block | ||
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|[[Pancuronium]] (Pavulon) | |[[Pancuronium]] (Pavulon) | ||
|90 | |90 | ||
|180 or more | |180 or more | ||
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*[[tachycardia]] (slight) | *[[tachycardia]] (slight) | ||
(no hypotension) | (no hypotension) | ||
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Revision as of 03:32, 24 February 2015
Background
- Non-depolarizing
- Competitively block binding of ACh to its receptors
- Depolarizing
- Depolarizing skeletal muscle fiber
- Persistent depolarization makes the muscle fiber resistant to further stimulation by ACh
Types
| Agent | Time to onset (seconds) |
Duration (minutes) |
Side effects | Clinical use |
|---|---|---|---|---|
| Non-Depolarizing | ||||
| Succinylcholine | fasciculations, post-operative pain | |||
| Depolarizing | ||||
| Atracurium (Tracrium) | 90 | 30 min or less[1] |
| |
| Vecuronium (Norcuron) | 60 | 30–40 | Few, may cause prolonged paralysis and promote muscarinic block | |
| Rocuronium (Zemuron) | 75 | 45–70 | may promote muscarinic block | |
| Pancuronium (Pavulon) | 90 | 180 or more |
(no hypotension) |