Antidotes: Difference between revisions
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| [[Cyanide]] | | [[Cyanide]] | ||
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Kit | Hydroxycobalamin | ||
OR | |||
Cyanide Antidote Kit (Amyl Nitrite, Sodium Nitrite, and Sodium Thiosulfate) | |||
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Fomepizole | Fomepizole | ||
15mg/kg IV; then 10mg/kg q12h | |||
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| [[Heparin (Unfractionated)|Heparin]] | | [[Heparin (Unfractionated)|Heparin]] | ||
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Protamine | Protamine Sulfate | ||
Adult: 25-50mg IV (empiric dose) over 10 minutes | Adult: 25-50mg IV (empiric dose) over 10 minutes | ||
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Peds: 0.6mg/kg IV (empiric dose) | Peds: 0.6mg/kg IV (empiric dose) | ||
'' | ''Note: Rapid protamine infusion causes hypotension''<ref>Hirsh J. et al. "Parenteral anticoagulants: ACCP Evidence-Based Clinical Practice Guidelines. Chest 2008; 133</ref> | ||
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| [[Iron (Fe)|Iron]] | | [[Iron (Fe)|Iron]] | ||
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| [[Organophosphates]] | | [[Organophosphates]] | ||
| [[Atropine]]+ | | [[Atropine]] + Pralidoxime | ||
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| [[Sulfonylurea Toxicity|Sulfonylurea]] | | [[Sulfonylurea Toxicity|Sulfonylurea]] | ||
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| [[Valproic acid toxicity|Valproate]] | | [[Valproic acid toxicity|Valproate]] | ||
| Carnitine | | L-Carnitine | ||
|- | |- | ||
| [[Warfarin (Coumadin) Reversal|Warfarin]] | | [[Warfarin (Coumadin) Reversal|Warfarin]] | ||
Revision as of 04:38, 5 March 2015
|
TOXIN |
ANTIDOTE |
| Acetaminophen |
150mg/kg IV load over 60min; followed by 50mg/kg IV over 4hr and then 100mg/kg IV over 16hr |
| Tricyclic (TCA) Toxicity |
Bicarbonate 1-2mEq/kg IV bolus followed by 2mEq/kg/hr IV infusion |
| Arsenic | Dimercaprol (BAL) |
| Benzodiazepines |
Flumazenil Adult: 0.2mg IV Peds: 0.01mg/kg IV |
| Beta blockers |
Adult: 3-10mg IV Peds: 50-150mcg/kg IV |
|
Calcium chloride 10% Adult: 10 mL IV Peds: 0.2-0.25 mL/kg IV | |
|
Adult: 0.4-2mg IV Peds: 0.1mg/kg IV (max 2mg) | |
| Cyanide |
Hydroxycobalamin OR Cyanide Antidote Kit (Amyl Nitrite, Sodium Nitrite, and Sodium Thiosulfate) |
| Digoxin | Dig Immune Fab |
| Ethylene glycol |
Fomepizole 15mg/kg IV; then 10mg/kg q12h |
| Fluoride | Calcium Gluconate |
| Heparin |
Protamine Sulfate Adult: 25-50mg IV (empiric dose) over 10 minutes Peds: 0.6mg/kg IV (empiric dose) Note: Rapid protamine infusion causes hypotension[1] |
| Iron | Deferoxamine |
| Isoniazid (INH) |
Pyridoxine (Vit B6) Adult: 5gm IV Peds: 1gm/kg regardless of age [2] |
| Lead | EDTA, succimer |
| Mercury | Dimercaprol (BAL) |
| Methanol | Fomepizole
15mi/kg IV; then 10mg/kg q12h |
| Methemoglobinemia | Methylene blue |
| Opiods | Naloxone |
| Organophosphates | Atropine + Pralidoxime |
| Sulfonylurea |
Octreotide Adult: 50–100mcg SC q6hr Peds: 1mcg/kg SC q6hr |
| Valproate | L-Carnitine |
| Warfarin | Vitamin K, FFP, Prothrombin Complex Concentrates |
Source
<references>