Naloxone: Difference between revisions
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==Adverse Reactions== | ==Adverse Reactions== | ||
*[[Opioid withdrawal]] | |||
*Serious complications are rare | |||
===Serious=== | ===Serious=== | ||
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*Excretion: | *Excretion: | ||
*Mechanism of Action: | *Mechanism of Action: | ||
*Onset of action - 1-2min | |||
*Duration of action - 20-90min ('''may be less than that of the ingested opioid''') | |||
==See Also== | ==See Also== | ||
Revision as of 16:24, 12 March 2015
General
- Type: Opiod antagonists
- Dosage Forms:
- Common Trade Names: Narcan
Adult Dosing
Opioid toxicity
- Bolus (May repeat q3min up to max dose 10mg
- Apneic or near-apneic - 2mg IV
- Opioid-naive with minimal respiratory depression - 0.4mg IV
- Opioid-dependent with minimal respiratory depression - 0.05mg IV
- Infusion
- Only give if the pt responded to the bolus and required repeat administration
- Step 1: Determine the "wake-up dose" or bolus required to wake the pt
- Step 2: Give 2/3 of the "wake-up dose" per hr; mix in 1L D5W
Pediatric Dosing
Special Populations
- Pregnancy Rating:
- Lactation:
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
- Opioid withdrawal
- Serious complications are rare
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
- Onset of action - 1-2min
- Duration of action - 20-90min (may be less than that of the ingested opioid)