Altered mental status: Difference between revisions

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==Differential Diagnosis==
==Differential Diagnosis==
#Diffuse brain dysfunction
{{AMS DDX}}
##Encephalopathies
###Hypoxic encephalopathy
###Metabolic encephalopathy
####[[Hypoglycemia]]
####Hyperosmolar state (e.g., [[hyperglycemia]])
####[[Electrolyte Abnormalities]] ([[hypernatremia]] or [[hyponatremia]], [[hypercalcemia]])
####Organ system failure
####[[Hepatic Encephalopathy]]
####[[Uremia]]/[[Renal Failure]]
####Endocrine (Addison disease, [[hypothyroidism]])
####Hypoxia
####CO2 narcosis
###[[Hypertensive Encephalopathy]]
##Toxins
##Drug reactions (NMS)
##Environmental causes
###[[Hypothermia]]
###[[Hyperthermia]]
##Deficiency state
###[[Wernicke encephalopathy]]
##[[Sepsis]]
#Primary CNS disease or trauma
##Direct CNS trauma
###Diffuse axonal injury
###Subdural/epidural hematoma
##Vascular disease
###Intraparenchymal hemorrhage
##[[SAH]]
##Infarction
###Hemispheric, brainstem
##CNS infections
##Neoplasms
##[[Seizures]]
###Nonconvulsive status epilepticus
####Consider if motor activity of seizure has stopped but pt is not alert w/in 30min
###Postictal state


==Work-Up==
==Work-Up==

Revision as of 17:10, 24 March 2015

Background

  • Alteration of arousal or content of consciousness or both
  • Both cerebral cortices or brainstem must be affected
  • Delirium vs dementia vs psych
  • Must quickly determine if coma is from diffuse or focal impairment
  • Peds
    • Most common causes are toxic ingestion, infection, and child-abuse induced trauma

Clinical Features

  • Depends on cause
    • Diffuse brain dysfunction - lack of focal findings
    • Focal brain dysfunction - hemiparesis, loss of motor tone, loss of ocular reflexes

Differential Diagnosis

Altered mental status

Diffuse brain dysfunction

Primary CNS disease or trauma

Psychiatric

Work-Up

  1. Stat D-stick
  2. CBC
  3. Chemistry
  4. LFTs
  5. UA
  6. CXR
  7. Utox
  8. EKG
  9. Head CT
  10. ?Blood and urine cultures
  11. ?Ammonia level
  12. ?Tylenol/ASA level
  13. ?LP
  14. ?Serum Osm
  15. ?Coags
  16. ?TFTs
  17. ?Cortisol
  18. ?ABG/VBG

Treatment

  • Pts w/ focal findings may have surgically treatable cause
  • Coma cocktail
    • Glucose, thiamine, naloxone
  • Underlying cause

See Also

Source

Tintinalli