Nitrous oxide toxicity: Difference between revisions
Ostermayer (talk | contribs) |
|||
| Line 31: | Line 31: | ||
==See Also== | ==See Also== | ||
*[[Nitrous oxide]] | |||
==External Links== | ==External Links== | ||
Revision as of 20:39, 17 May 2023
Background
- Nitrous oxide toxicity is often associated with inhalation of whipped cream or small nitrous oxide cannisters (whippets)
- Nitrous is much more soluble in blood and will quickly diffuse from the blood to a closed space
- Beyond the gaseous effects nitrous oxide mainly disrupts B12 by oxidizing the cobolt ion which irreversibly inhibits methionine synthase[1]
Clinical Features
Differential Diagnosis
Acute complications
- Pneumothorax (induced by forceful inhalation or high preassure tank siphoning)
- Typanic membrane rupture
- Tracheal trauma
- Air emboli
Chronic complications
- Bone marrow suppression (from long term exposure)
Evaluation
Workup
Diagnosis
Management
Disposition
See Also
External Links
References
- ↑ Nunn J. Clinical aspects of the interaction between nitrous oxide and vitamin B12. British Joural of Anaesthesia. 1987; 59:3-13