Template:Weakness DDX: Difference between revisions

Latest revision as of 14:01, 17 June 2023

Weakness

Neuromuscular weakness
- Upper motor neuron:
  - CVA
  - Hemorrhagic stroke
  - Multiple sclerosis
  - Amyotrophic Lateral Sclerosis (ALS) (upper and lower motor neuron)
- Lower motor neuron:
  - Spinal and bulbar muscular atrophy (Kennedy's syndrome)
- Spinal cord disease:
  - Infection (Epidural abscess)
  - Infarction/ischemia
  - Trauma (Spinal Cord Syndromes)
  - Inflammation (Transverse Myelitis)
    - Acute flaccid myelitis
  - Degenerative (Spinal muscular atrophy)
  - Tumor
- Peripheral nerve disease:
  - Guillain-Barre syndrome
  - Toxins (Ciguatera)
  - Tick paralysis
  - Diabetic peripheral neuropathy
- Neuromuscular junction disease:
- Muscle disease:
  - Rhabdomyolysis
  - Dermatomyositis
  - Polymyositis
  - Alcoholic myopathy
Non-neuromuscular weakness
- Can't miss diagnoses:
  - ACS
  - Arrhythmia/Syncope
  - Severe infection/Sepsis
  - Hypoglycemia
  - Periodic paralysis (electrolyte disturbance, K, Mg, Ca)
    - Hypokalemic periodic paralysis
    - Thyrotoxic periodic paralysis
  - Respiratory failure
- Emergent Diagnoses:
  - Symptomatic Anemia
  - Severe dehydration
  - Hypothyroidism
  - Polypharmacy
  - Malignancy
  - Aortic disease - occlusion, stenosis, dissection
- Other causes of weakness and paralysis
  - Acute intermittent porphyria (ascending weakness)

@@ Line 1: / Line 1: @@
 ===[[Weakness]]===
 *'''Neuromuscular weakness'''
-**'''UMN:'''
+**Upper motor neuron:
-*** [[CVA (Main)]]
+*** [[CVA (Main)|CVA]]
 *** [[Hemorrhagic stroke]]
 *** [[Multiple sclerosis]]
-*** [[Amyotrophic Lateral Sclerosis (ALS)]] (UMN & LMN)
+*** [[Amyotrophic Lateral Sclerosis (ALS)]] (upper and lower motor neuron)
-**'''Spinal cord disease:'''
+**Lower motor neuron:
-*** Infection ([[Epidural Abscess (Spinal)]])
+*** Spinal and bulbar muscular atrophy (Kennedy's syndrome)
+**Spinal cord disease:
+*** Infection ([[Epidural Abscess (Spinal)|Epidural abscess]])
 *** Infarction/ischemia
 *** Trauma ([[Spinal Cord Syndromes]])
 *** Inflammation ([[Transverse Myelitis]])
+****[[Acute flaccid myelitis]]
+*** Degenerative ([[Spinal muscular atrophy]])
 *** Tumor
-**'''Peripheral nerve disease:'''
+**Peripheral nerve disease:
-*** [[Guillain-Barre]]
+*** [[Guillain-Barre syndrome]]
 *** Toxins ([[Ciguatera]])
-*** [[Tick Paralysis]]
+*** [[Tick paralysis]]
-*** DM neuropathy (non-emergent)
+*** [[Diabetic peripheral neuropathy]]
-**'''NMJ disease:'''
+**Neuromuscular junction disease:
 *** [[Myasthenia gravis]] crisis
 *** [[Botulism]]
-*** [[Organophosphate Toxicity]]
+*** [[Organophosphate toxicity]]
-*** [[Lambert-Eaton Myasthenic Syndrome]]
+*** [[Lambert-Eaton myasthenic syndrome]]
-**'''Muscle disease:'''
+**Muscle disease:
 *** [[Rhabdomyolysis]]
-*** Dermatomyositis
+*** [[Dermatomyositis]]
-*** Polymyositis
+*** [[Polymyositis]]
 *** Alcoholic myopathy
 *'''Non-neuromuscular weakness'''
-**'''Can't miss diagnoses:'''
+**Can't miss diagnoses:
-*** [[Acute Coronary Syndrome (Main)]]
+*** [[Acute Coronary Syndrome (Main)|ACS]]
-*** Arrhythmia/[[Syncope]]
+*** [[Arrhythmia]]/[[Syncope]]
-*** severe infection/[[Sepsis (Main)]]
+*** Severe infection/[[Sepsis (Main)|Sepsis]]
 *** [[Hypoglycemia]]
-*** Periodic paralysis (electrolyte disturbance, K, Mg, Ca)
+*** Periodic paralysis ([[electrolyte disturbance]], K, Mg, Ca)
 ****[[Hypokalemic periodic paralysis]]
-*** Respiratory failure
+****[[Thyrotoxic periodic paralysis]]
-**'''Emergent Diagnoses:'''
+*** [[Respiratory failure]]
+**Emergent Diagnoses:
 *** Symptomatic [[Anemia]]
-*** Severe dehydration
+*** Severe [[dehydration]]
 *** [[Hypothyroidism]]
 *** Polypharmacy
 *** Malignancy
+*** Aortic disease - occlusion, stenosis, dissection
+**Other causes of weakness and paralysis
+***[[Acute intermittent porphyria]] (ascending weakness)