Benzodiazepines: Difference between revisions
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==Background== | ==Background== | ||
* | *A [[Benzodiazepine]] is a GABA receptor agonist. | ||
*Binding results in inhibition of neuronal firing | *Binding results in inhibition of neuronal firing | ||
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| align="center" style="background:#f0f0f0;"|'''Duration (hours)''' | | align="center" style="background:#f0f0f0;"|'''Duration (hours)''' | ||
|- | |- | ||
| [[Alprazolam]] (Xanax)||0.5mg||15-30 || 6-12 | | [[Has DrugName::Alprazolam]] (Xanax)||0.5mg||15-30 || 6-12 | ||
|- | |- | ||
| [[Chlordiazepoxide]] (Librium)||25mg||30-60 || 24-48 | | [[Has DrugName::Chlordiazepoxide]] (Librium)||25mg||30-60 || 24-48 | ||
|- | |- | ||
| [[Diazepam]] (Valium)||5mg||2-5 (IV) ||6-12 | | [[Has DrugName::Diazepam]] (Valium)||5mg||2-5 (IV) ||6-12 | ||
|- | |- | ||
| [[Flurazepam]] (Dalmane)||15mg||15-60 || 24-48 | | [[Has DrugName::Flurazepam]] (Dalmane)||15mg||15-60 || 24-48 | ||
|- | |- | ||
| [[Lorazepam]] (Ativan)||1mg||5-20(IV); 15-30 (IM)||6-8 | | [[Has DrugName::Lorazepam]] (Ativan)||1mg||5-20(IV); 15-30 (IM)||6-8 | ||
|- | |- | ||
| [[Midazolam]] (Versed)||5mg||15(IM)||1-2 | | [[Has DrugName::Midazolam]] (Versed)||5mg||15(IM)||1-2 | ||
|- | |- | ||
| [[Oxazepam]] (Serax)||15mg|| 30-60 ||6-8 | | [[Has DrugName::Oxazepam]] (Serax)||15mg|| 30-60 ||6-8 | ||
|- | |- | ||
| [[Temazepam]] (Restoril)||15mg||30||2-4 | | [[Has DrugName::Temazepam]] (Restoril)||15mg||30||2-4 | ||
|} | |} | ||
==Uses== | ==Uses== | ||
Latest revision as of 14:31, 18 July 2025
Background
- A Benzodiazepine is a GABA receptor agonist.
- Binding results in inhibition of neuronal firing
Table
| Generic (Trade Name) | Equivalent Oral Dose | Onset (minutes) | Duration (hours) |
| Alprazolam (Xanax) | 0.5mg | 15-30 | 6-12 |
| Chlordiazepoxide (Librium) | 25mg | 30-60 | 24-48 |
| Diazepam (Valium) | 5mg | 2-5 (IV) | 6-12 |
| Flurazepam (Dalmane) | 15mg | 15-60 | 24-48 |
| Lorazepam (Ativan) | 1mg | 5-20(IV); 15-30 (IM) | 6-8 |
| Midazolam (Versed) | 5mg | 15(IM) | 1-2 |
| Oxazepam (Serax) | 15mg | 30-60 | 6-8 |
| Temazepam (Restoril) | 15mg | 30 | 2-4 |
Uses
- Sedation
- Seizures
- Alcohol Withdrawal
- Panic disorder, Generalized Anxiety Disorder, Anxiety
- Insomnia
- Muscle Spasms