Nucleoside analog: Difference between revisions

Revision as of 15:41, 30 August 2025

Nucleoside analoges are a class of antiviral medications that mimic the structure of natural nucleosides, interfering with viral DNA or RNA synthesis
Primarily used for treatment of herpesvirus infections (e.g., HSV, VZV), HIV, hepatitis B and C, and some other viral infections
Work by being incorporated into viral nucleic acids, leading to chain termination or mutagenesis

Neurotoxicity (e.g., cidofovir, tenofovir)
Nephrotoxicity (e.g., acyclovir in renal impairment)
Lactic acidosis and hepatotoxicity (e.g., nucleoside reverse transcriptase inhibitors like zidovudine)
Bone density loss (e.g., tenofovir)
Teratogenicity (e.g., ribavirin contraindicated in pregnancy)

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+==Mechanism of Action==
+*Nucleoside analoges are a class of antiviral medications that mimic the structure of natural nucleosides, interfering with viral DNA or RNA synthesis
+*Primarily used for treatment of herpesvirus infections (e.g., HSV, VZV), HIV, hepatitis B and C, and some other viral infections
+*Work by being incorporated into viral nucleic acids, leading to chain termination or mutagenesis
+==Adverse Effects==
+===Common===
+*Nausea, vomiting, diarrhea
+*Headache, fatigue
+*Rash or pruritus
+*Bone marrow suppression (e.g., zidovudine)
+===Serious===
+*Neurotoxicity (e.g., cidofovir, tenofovir)
+*Nephrotoxicity (e.g., acyclovir in renal impairment)
+*Lactic acidosis and hepatotoxicity (e.g., nucleoside reverse transcriptase inhibitors like zidovudine)
+*Bone density loss (e.g., tenofovir)
+*Teratogenicity (e.g., ribavirin contraindicated in pregnancy)
 {{#ask:[[Is DrugClass::nucleoside analoge]] |format=ul }}
 [[Category:Pharmacology]]